Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment

Central nervous system (CNS) metastases represent a major problem in the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer because of the disappointing efficacy of HER2-targeted therapies against brain lesions. The antibody-drug conjugate ado-trastuzumab emtansine (...

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Veröffentlicht in:JNCI : Journal of the National Cancer Institute 2016-02, Vol.108 (2), p.1
Hauptverfasser: Askoxylakis, Vasileios, Ferraro, Gino B, Kodack, David P, Badeaux, Mark, Shankaraiah, Ram C, Seano, Giorgio, Kloepper, Jonas, Vardam, Trupti, Martin, John D, Naxerova, Kamila, Bezwada, Divya, Qi, Xiaolong, Selig, Martin K, Brachtel, Elena, Duda, Dan G, Huang, Peigen, Fukumura, Dai, Engelman, Jeffrey A, Jain, Rakesh K
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Sprache:eng
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