Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133+ Circulating Angiogenic Cells
OBJECTIVES—Previous studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease risk. Yet, the nature of this association remains unclear, and its effect on individual cardiovascular disease risk factors has not been assessed. The objective of this...
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| creator | DeJarnett, Natasha Yeager, Ray Conklin, Daniel J Lee, Jongmin O’Toole, Timothy E McCracken, James Abplanalp, Wes Srivastava, Sanjay Riggs, Daniel W Hamzeh, Ihab Wagner, Stephen Chugh, Atul DeFilippis, Andrew Ciszewski, Tiffany Wyatt, Brad Becher, Carrie Higdon, Deirdre Ramos, Kenneth S Tollerud, David J Myers, John A Rai, Shesh N Shah, Jasmit Zafar, Nagma Krishnasamy, Sathya S Prabhu, Sumanth D Bhatnagar, Aruni |
| description | OBJECTIVES—Previous studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease risk. Yet, the nature of this association remains unclear, and its effect on individual cardiovascular disease risk factors has not been assessed. The objective of this study was to determine whether residential proximity to roadways influences systemic inflammation and the levels of circulating angiogenic cells.
APPROACH AND RESULTS—In a cross-sectional study, cardiovascular disease risk factors, blood levels of C-reactive protein, and 15 antigenically defined circulating angiogenic cell populations were measured in participants (n=316) with moderate-to-high cardiovascular disease risk. Attributes of roadways surrounding residential locations were assessed using geographic information systems. Associations between road proximity and cardiovascular indices were analyzed using generalized linear models. Close proximity ( |
| doi_str_mv | 10.1161/ATVBAHA.115.305724 |
| format | Article |
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APPROACH AND RESULTS—In a cross-sectional study, cardiovascular disease risk factors, blood levels of C-reactive protein, and 15 antigenically defined circulating angiogenic cell populations were measured in participants (n=316) with moderate-to-high cardiovascular disease risk. Attributes of roadways surrounding residential locations were assessed using geographic information systems. Associations between road proximity and cardiovascular indices were analyzed using generalized linear models. Close proximity (<50 m) to a major roadway was associated with lower income and higher rates of smoking but not C-reactive protein levels. After adjustment for potential confounders, the levels of circulating angiogenic cells in peripheral blood were significantly elevated in people living in close proximity to a major roadway (CD31/AC133, AC133, CD34/AC133, and CD34/45/AC133 cells) and positively associated with road segment distance (CD31/AC133, AC133, and CD34/AC133 cells), traffic intensity (CD31/AC133 and AC133 cells), and distance-weighted traffic intensity (CD31/34/45/AC133 cells).
CONCLUSIONS—Living close to a major roadway is associated with elevated levels of circulating cells positive for the early stem marker AC133. This may reflect an increased need for vascular repair. Levels of these cells in peripheral blood may be a sensitive index of cardiovascular injury because of residential proximity to roadways.</description><identifier>ISSN: 1079-5642</identifier><identifier>EISSN: 1524-4636</identifier><identifier>DOI: 10.1161/ATVBAHA.115.305724</identifier><identifier>PMID: 26293462</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>AC133 Antigen ; Adult ; Antigens, CD - blood ; Automobiles ; Biomarkers - blood ; Cell Count ; Cross-Sectional Studies ; Endothelial Progenitor Cells - drug effects ; Endothelial Progenitor Cells - immunology ; Endothelial Progenitor Cells - metabolism ; Environmental Exposure - adverse effects ; Environmental Pollutants - adverse effects ; Female ; Glycoproteins - blood ; Humans ; Inflammation Mediators - blood ; Kentucky ; Male ; Middle Aged ; Peptides - blood ; Residence Characteristics ; Up-Regulation ; Vehicle Emissions</subject><ispartof>Arteriosclerosis, thrombosis, and vascular biology, 2015-11, Vol.35 (11), p.2468-2477</ispartof><rights>2015 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4984-4bf2e6f4212901aed07bc937e24f0c7a07d0587827b96e27db222a39bf7f5b283</citedby><cites>FETCH-LOGICAL-c4984-4bf2e6f4212901aed07bc937e24f0c7a07d0587827b96e27db222a39bf7f5b283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26293462$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DeJarnett, Natasha</creatorcontrib><creatorcontrib>Yeager, Ray</creatorcontrib><creatorcontrib>Conklin, Daniel J</creatorcontrib><creatorcontrib>Lee, Jongmin</creatorcontrib><creatorcontrib>O’Toole, Timothy E</creatorcontrib><creatorcontrib>McCracken, James</creatorcontrib><creatorcontrib>Abplanalp, Wes</creatorcontrib><creatorcontrib>Srivastava, Sanjay</creatorcontrib><creatorcontrib>Riggs, Daniel W</creatorcontrib><creatorcontrib>Hamzeh, Ihab</creatorcontrib><creatorcontrib>Wagner, Stephen</creatorcontrib><creatorcontrib>Chugh, Atul</creatorcontrib><creatorcontrib>DeFilippis, Andrew</creatorcontrib><creatorcontrib>Ciszewski, Tiffany</creatorcontrib><creatorcontrib>Wyatt, Brad</creatorcontrib><creatorcontrib>Becher, Carrie</creatorcontrib><creatorcontrib>Higdon, Deirdre</creatorcontrib><creatorcontrib>Ramos, Kenneth S</creatorcontrib><creatorcontrib>Tollerud, David J</creatorcontrib><creatorcontrib>Myers, John A</creatorcontrib><creatorcontrib>Rai, Shesh N</creatorcontrib><creatorcontrib>Shah, Jasmit</creatorcontrib><creatorcontrib>Zafar, Nagma</creatorcontrib><creatorcontrib>Krishnasamy, Sathya S</creatorcontrib><creatorcontrib>Prabhu, Sumanth D</creatorcontrib><creatorcontrib>Bhatnagar, Aruni</creatorcontrib><title>Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133+ Circulating Angiogenic Cells</title><title>Arteriosclerosis, thrombosis, and vascular biology</title><addtitle>Arterioscler Thromb Vasc Biol</addtitle><description>OBJECTIVES—Previous studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease risk. Yet, the nature of this association remains unclear, and its effect on individual cardiovascular disease risk factors has not been assessed. The objective of this study was to determine whether residential proximity to roadways influences systemic inflammation and the levels of circulating angiogenic cells.
APPROACH AND RESULTS—In a cross-sectional study, cardiovascular disease risk factors, blood levels of C-reactive protein, and 15 antigenically defined circulating angiogenic cell populations were measured in participants (n=316) with moderate-to-high cardiovascular disease risk. Attributes of roadways surrounding residential locations were assessed using geographic information systems. Associations between road proximity and cardiovascular indices were analyzed using generalized linear models. Close proximity (<50 m) to a major roadway was associated with lower income and higher rates of smoking but not C-reactive protein levels. After adjustment for potential confounders, the levels of circulating angiogenic cells in peripheral blood were significantly elevated in people living in close proximity to a major roadway (CD31/AC133, AC133, CD34/AC133, and CD34/45/AC133 cells) and positively associated with road segment distance (CD31/AC133, AC133, and CD34/AC133 cells), traffic intensity (CD31/AC133 and AC133 cells), and distance-weighted traffic intensity (CD31/34/45/AC133 cells).
CONCLUSIONS—Living close to a major roadway is associated with elevated levels of circulating cells positive for the early stem marker AC133. This may reflect an increased need for vascular repair. Levels of these cells in peripheral blood may be a sensitive index of cardiovascular injury because of residential proximity to roadways.</description><subject>AC133 Antigen</subject><subject>Adult</subject><subject>Antigens, CD - blood</subject><subject>Automobiles</subject><subject>Biomarkers - blood</subject><subject>Cell Count</subject><subject>Cross-Sectional Studies</subject><subject>Endothelial Progenitor Cells - drug effects</subject><subject>Endothelial Progenitor Cells - immunology</subject><subject>Endothelial Progenitor Cells - metabolism</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental Pollutants - adverse effects</subject><subject>Female</subject><subject>Glycoproteins - blood</subject><subject>Humans</subject><subject>Inflammation Mediators - blood</subject><subject>Kentucky</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Peptides - blood</subject><subject>Residence Characteristics</subject><subject>Up-Regulation</subject><subject>Vehicle Emissions</subject><issn>1079-5642</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcFu1DAQjRCIlsIPcEA-IqEt9sSxkwtSiICutAhUFThajjPZdfHGre102b_H1S4VXDjNPM2bN_P0iuIlo-eMCfa2vfr-vr1oM6jOS1pJ4I-KU1YBX3BRise5p7JZVILDSfEsxmtKKQegT4sTENCUXMBpES4x2gGnZLUjX4P_Zbc27Uny5LO-9oFcej3s9D6SZSRtjN5YnXAgP2zakOVkAuqY4Qrv0EXiR9J2rCzfkM4GMzud7LQm7bS2fo2TNaRD5-Lz4smoXcQXx3pWfPv44aq7WKy-fFp27WpheFNnD_0IKEYODBrKNA5U9qYpJQIfqZGayoFWtaxB9o1AkEMPALps-lGOVQ91eVa8O-jezP0WB5NNBu3UTbBbHfbKa6v-nUx2o9b-TvFaAKf3Aq-PAsHfzhiT2tposgU9oZ-jYhIkL2suWKbCgWqCjzHg-HCGUXUfljqGlUGlDmHlpVd_P_iw8iedTBAHws67hCH-dPMOg9qgdmnzP-Xf716iZw</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>DeJarnett, Natasha</creator><creator>Yeager, Ray</creator><creator>Conklin, Daniel J</creator><creator>Lee, Jongmin</creator><creator>O’Toole, Timothy E</creator><creator>McCracken, James</creator><creator>Abplanalp, Wes</creator><creator>Srivastava, Sanjay</creator><creator>Riggs, Daniel W</creator><creator>Hamzeh, Ihab</creator><creator>Wagner, Stephen</creator><creator>Chugh, Atul</creator><creator>DeFilippis, Andrew</creator><creator>Ciszewski, Tiffany</creator><creator>Wyatt, Brad</creator><creator>Becher, Carrie</creator><creator>Higdon, Deirdre</creator><creator>Ramos, Kenneth S</creator><creator>Tollerud, David J</creator><creator>Myers, John A</creator><creator>Rai, Shesh N</creator><creator>Shah, Jasmit</creator><creator>Zafar, Nagma</creator><creator>Krishnasamy, Sathya S</creator><creator>Prabhu, Sumanth D</creator><creator>Bhatnagar, Aruni</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201511</creationdate><title>Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133+ Circulating Angiogenic Cells</title><author>DeJarnett, Natasha ; Yeager, Ray ; Conklin, Daniel J ; Lee, Jongmin ; O’Toole, Timothy E ; McCracken, James ; Abplanalp, Wes ; Srivastava, Sanjay ; Riggs, Daniel W ; Hamzeh, Ihab ; Wagner, Stephen ; Chugh, Atul ; DeFilippis, Andrew ; Ciszewski, Tiffany ; Wyatt, Brad ; Becher, Carrie ; Higdon, Deirdre ; Ramos, Kenneth S ; Tollerud, David J ; Myers, John A ; Rai, Shesh N ; Shah, Jasmit ; Zafar, Nagma ; Krishnasamy, Sathya S ; Prabhu, Sumanth D ; Bhatnagar, Aruni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4984-4bf2e6f4212901aed07bc937e24f0c7a07d0587827b96e27db222a39bf7f5b283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>AC133 Antigen</topic><topic>Adult</topic><topic>Antigens, CD - blood</topic><topic>Automobiles</topic><topic>Biomarkers - blood</topic><topic>Cell Count</topic><topic>Cross-Sectional Studies</topic><topic>Endothelial Progenitor Cells - drug effects</topic><topic>Endothelial Progenitor Cells - immunology</topic><topic>Endothelial Progenitor Cells - metabolism</topic><topic>Environmental Exposure - adverse effects</topic><topic>Environmental Pollutants - adverse effects</topic><topic>Female</topic><topic>Glycoproteins - blood</topic><topic>Humans</topic><topic>Inflammation Mediators - blood</topic><topic>Kentucky</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Peptides - blood</topic><topic>Residence Characteristics</topic><topic>Up-Regulation</topic><topic>Vehicle Emissions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DeJarnett, Natasha</creatorcontrib><creatorcontrib>Yeager, Ray</creatorcontrib><creatorcontrib>Conklin, Daniel J</creatorcontrib><creatorcontrib>Lee, Jongmin</creatorcontrib><creatorcontrib>O’Toole, Timothy E</creatorcontrib><creatorcontrib>McCracken, James</creatorcontrib><creatorcontrib>Abplanalp, Wes</creatorcontrib><creatorcontrib>Srivastava, Sanjay</creatorcontrib><creatorcontrib>Riggs, Daniel W</creatorcontrib><creatorcontrib>Hamzeh, Ihab</creatorcontrib><creatorcontrib>Wagner, Stephen</creatorcontrib><creatorcontrib>Chugh, Atul</creatorcontrib><creatorcontrib>DeFilippis, Andrew</creatorcontrib><creatorcontrib>Ciszewski, Tiffany</creatorcontrib><creatorcontrib>Wyatt, Brad</creatorcontrib><creatorcontrib>Becher, Carrie</creatorcontrib><creatorcontrib>Higdon, Deirdre</creatorcontrib><creatorcontrib>Ramos, Kenneth S</creatorcontrib><creatorcontrib>Tollerud, David J</creatorcontrib><creatorcontrib>Myers, John A</creatorcontrib><creatorcontrib>Rai, Shesh N</creatorcontrib><creatorcontrib>Shah, Jasmit</creatorcontrib><creatorcontrib>Zafar, Nagma</creatorcontrib><creatorcontrib>Krishnasamy, Sathya S</creatorcontrib><creatorcontrib>Prabhu, Sumanth D</creatorcontrib><creatorcontrib>Bhatnagar, Aruni</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DeJarnett, Natasha</au><au>Yeager, Ray</au><au>Conklin, Daniel J</au><au>Lee, Jongmin</au><au>O’Toole, Timothy E</au><au>McCracken, James</au><au>Abplanalp, Wes</au><au>Srivastava, Sanjay</au><au>Riggs, Daniel W</au><au>Hamzeh, Ihab</au><au>Wagner, Stephen</au><au>Chugh, Atul</au><au>DeFilippis, Andrew</au><au>Ciszewski, Tiffany</au><au>Wyatt, Brad</au><au>Becher, Carrie</au><au>Higdon, Deirdre</au><au>Ramos, Kenneth S</au><au>Tollerud, David J</au><au>Myers, John A</au><au>Rai, Shesh N</au><au>Shah, Jasmit</au><au>Zafar, Nagma</au><au>Krishnasamy, Sathya S</au><au>Prabhu, Sumanth D</au><au>Bhatnagar, Aruni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133+ Circulating Angiogenic Cells</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><addtitle>Arterioscler Thromb Vasc Biol</addtitle><date>2015-11</date><risdate>2015</risdate><volume>35</volume><issue>11</issue><spage>2468</spage><epage>2477</epage><pages>2468-2477</pages><issn>1079-5642</issn><eissn>1524-4636</eissn><abstract>OBJECTIVES—Previous studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease risk. Yet, the nature of this association remains unclear, and its effect on individual cardiovascular disease risk factors has not been assessed. The objective of this study was to determine whether residential proximity to roadways influences systemic inflammation and the levels of circulating angiogenic cells.
APPROACH AND RESULTS—In a cross-sectional study, cardiovascular disease risk factors, blood levels of C-reactive protein, and 15 antigenically defined circulating angiogenic cell populations were measured in participants (n=316) with moderate-to-high cardiovascular disease risk. Attributes of roadways surrounding residential locations were assessed using geographic information systems. Associations between road proximity and cardiovascular indices were analyzed using generalized linear models. Close proximity (<50 m) to a major roadway was associated with lower income and higher rates of smoking but not C-reactive protein levels. After adjustment for potential confounders, the levels of circulating angiogenic cells in peripheral blood were significantly elevated in people living in close proximity to a major roadway (CD31/AC133, AC133, CD34/AC133, and CD34/45/AC133 cells) and positively associated with road segment distance (CD31/AC133, AC133, and CD34/AC133 cells), traffic intensity (CD31/AC133 and AC133 cells), and distance-weighted traffic intensity (CD31/34/45/AC133 cells).
CONCLUSIONS—Living close to a major roadway is associated with elevated levels of circulating cells positive for the early stem marker AC133. This may reflect an increased need for vascular repair. Levels of these cells in peripheral blood may be a sensitive index of cardiovascular injury because of residential proximity to roadways.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>26293462</pmid><doi>10.1161/ATVBAHA.115.305724</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Arteriosclerosis, thrombosis, and vascular biology, 2015-11, Vol.35 (11), p.2468-2477 |
| issn | 1079-5642 1524-4636 |
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| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | AC133 Antigen Adult Antigens, CD - blood Automobiles Biomarkers - blood Cell Count Cross-Sectional Studies Endothelial Progenitor Cells - drug effects Endothelial Progenitor Cells - immunology Endothelial Progenitor Cells - metabolism Environmental Exposure - adverse effects Environmental Pollutants - adverse effects Female Glycoproteins - blood Humans Inflammation Mediators - blood Kentucky Male Middle Aged Peptides - blood Residence Characteristics Up-Regulation Vehicle Emissions |
| title | Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133+ Circulating Angiogenic Cells |
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