Transposable elements in the mammalian embryo: pioneers surviving through stealth and service

Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary time, TE insertions can supply new promoter, enhancer, and insulator elements to protein-coding genes and establish novel, species-specific gene regulatory networks. Conversely, ongoing TE-driven insertional mut...

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Veröffentlicht in:	Genome Biology 2016-05, Vol.17 (100), p.100-100, Article 100
Hauptverfasser:	Gerdes, Patricia, Richardson, Sandra R, Mager, Dixie L, Faulkner, Geoffrey J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Cell Differentiation - genetics Deoxyribonucleic acid DNA DNA methylation DNA Transposable Elements Embryonic development Embryonic Development - genetics Embryos Endogenous Retroviruses - genetics Epigenetic inheritance Epigenetics Evolution Gene expression Gene Expression Regulation, Developmental Genes Genetic aspects Genetic transcription Genomes Genomics Humans Insertional mutagenesis Leukemia Mammals Mutation Physiological aspects Pluripotency Polymorphism Proteins Recombination Review Stem cells Transposons Viruses
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