A study of oligoclonal band negative multiple sclerosis
OBJECTIVES--To determine whether oligoclonal band (OCB) negative multiple sclerosis is a reliable diagnosis and, if so, whether it has a distinctive prognosis. METHODS--Retrospective and matched prospective comparison of the clinical and laboratory features of patients with clinical definite multipl...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1996-01, Vol.60 (1), p.27-30 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
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| creator | Zeman, A Z Kidd, D McLean, B N Kelly, M A Francis, D A Miller, D H Kendall, B E Rudge, P Thompson, E J McDonald, W I |
| description | OBJECTIVES--To determine whether oligoclonal band (OCB) negative multiple sclerosis is a reliable diagnosis and, if so, whether it has a distinctive prognosis. METHODS--Retrospective and matched prospective comparison of the clinical and laboratory features of patients with clinical definite multiple sclerosis with and without intrathecal synthesis of oligoclonal IgG. RESULTS--Thirty four patients were identified with apparent OCB negative clinically definite multiple sclerosis. The results of oligoclonal banding proved to have been equivocal in 14 of 34; the clinical diagnosis of multiple sclerosis was questionable in 8 of 34. The remaining 12 patients with "true" OCB negative multiple sclerosis were significantly less disabled than matched OCB positive controls. Re-examination of CSF-serum pairs from six OCB negative patients showed that three remained OCB negative while three showed evidence of intrathecal synthesis of OCBs. CONCLUSIONS--OCB negative clinically definite multiple sclerosis is rare and should be diagnosed with caution; in unequivocal cases it seems to have a relatively benign prognosis. |
| doi_str_mv | 10.1136/jnnp.60.1.27 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_486185</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3984255561</sourcerecordid><originalsourceid>FETCH-LOGICAL-b571t-8f0c1fdd7db800d4ee999d53c40f588a2dbcf1549af39a006c2e2c5a99af1ee3</originalsourceid><addsrcrecordid>eNp9kc9rFDEUx4ModVu9eRUGlPbirElmMkkOHsrSVmFRCkV6C5n82GabSdZkptj_3iy7LG0PJofw8v28x5fvA-ADgnOEmu7rOoTNvCvFHNNXYIbajtVNA29fgxmEGNcNJPAtOM55DbeH8SNwxAhhBZwBel7lcdKPVbRV9G4VlY9B-qqXQVfBrOToHkw1TH50G2-qrLxJMbv8Dryx0mfzfv-egJvLi5vF93r56-rH4nxZ94SisWYWKmS1prpnEOrWGM65Jo1qoSWMSax7ZRFpubQNlxB2ChusiOTlAxnTnIBvu7GbqR-MViaMSXqxSW6Q6VFE6cRzJbg7sYoPomUdYqT0n-77U_wzmTyKwWVlvJfBxCkLSnlX7hb89AJcxymVJLJAlJYIW9zyQn3ZUaqEkJOxBycIiu0yxHYZoiuFwLTgH5-6P8D79Iv-ea_LrKS3SQbl8gHDnHIMYcHqHebyaP4eZJnuRUcbSsTP3wuB4fU1X9JLcVv4sx3fD-v_G_wHx-ivfA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1773054249</pqid></control><display><type>article</type><title>A study of oligoclonal band negative multiple sclerosis</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Zeman, A Z ; Kidd, D ; McLean, B N ; Kelly, M A ; Francis, D A ; Miller, D H ; Kendall, B E ; Rudge, P ; Thompson, E J ; McDonald, W I</creator><creatorcontrib>Zeman, A Z ; Kidd, D ; McLean, B N ; Kelly, M A ; Francis, D A ; Miller, D H ; Kendall, B E ; Rudge, P ; Thompson, E J ; McDonald, W I</creatorcontrib><description>OBJECTIVES--To determine whether oligoclonal band (OCB) negative multiple sclerosis is a reliable diagnosis and, if so, whether it has a distinctive prognosis. METHODS--Retrospective and matched prospective comparison of the clinical and laboratory features of patients with clinical definite multiple sclerosis with and without intrathecal synthesis of oligoclonal IgG. RESULTS--Thirty four patients were identified with apparent OCB negative clinically definite multiple sclerosis. The results of oligoclonal banding proved to have been equivocal in 14 of 34; the clinical diagnosis of multiple sclerosis was questionable in 8 of 34. The remaining 12 patients with "true" OCB negative multiple sclerosis were significantly less disabled than matched OCB positive controls. Re-examination of CSF-serum pairs from six OCB negative patients showed that three remained OCB negative while three showed evidence of intrathecal synthesis of OCBs. CONCLUSIONS--OCB negative clinically definite multiple sclerosis is rare and should be diagnosed with caution; in unequivocal cases it seems to have a relatively benign prognosis.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.60.1.27</identifier><identifier>PMID: 8558146</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Adult ; Biological and medical sciences ; Disabled Persons ; Female ; Humans ; Immunoglobulin G - immunology ; Immunoglobulins - blood ; Immunoglobulins - cerebrospinal fluid ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Multiple Sclerosis - classification ; Multiple Sclerosis - diagnosis ; Multiple Sclerosis - immunology ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Oligoclonal Bands ; Prognosis ; Prospective Studies ; Reproducibility of Results ; Retrospective Studies</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 1996-01, Vol.60 (1), p.27-30</ispartof><rights>1996 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Jan 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b571t-8f0c1fdd7db800d4ee999d53c40f588a2dbcf1549af39a006c2e2c5a99af1ee3</citedby><cites>FETCH-LOGICAL-b571t-8f0c1fdd7db800d4ee999d53c40f588a2dbcf1549af39a006c2e2c5a99af1ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC486185/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC486185/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,309,310,314,727,780,784,789,790,885,4050,4051,23930,23931,25140,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2979200$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8558146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeman, A Z</creatorcontrib><creatorcontrib>Kidd, D</creatorcontrib><creatorcontrib>McLean, B N</creatorcontrib><creatorcontrib>Kelly, M A</creatorcontrib><creatorcontrib>Francis, D A</creatorcontrib><creatorcontrib>Miller, D H</creatorcontrib><creatorcontrib>Kendall, B E</creatorcontrib><creatorcontrib>Rudge, P</creatorcontrib><creatorcontrib>Thompson, E J</creatorcontrib><creatorcontrib>McDonald, W I</creatorcontrib><title>A study of oligoclonal band negative multiple sclerosis</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>OBJECTIVES--To determine whether oligoclonal band (OCB) negative multiple sclerosis is a reliable diagnosis and, if so, whether it has a distinctive prognosis. METHODS--Retrospective and matched prospective comparison of the clinical and laboratory features of patients with clinical definite multiple sclerosis with and without intrathecal synthesis of oligoclonal IgG. RESULTS--Thirty four patients were identified with apparent OCB negative clinically definite multiple sclerosis. The results of oligoclonal banding proved to have been equivocal in 14 of 34; the clinical diagnosis of multiple sclerosis was questionable in 8 of 34. The remaining 12 patients with "true" OCB negative multiple sclerosis were significantly less disabled than matched OCB positive controls. Re-examination of CSF-serum pairs from six OCB negative patients showed that three remained OCB negative while three showed evidence of intrathecal synthesis of OCBs. CONCLUSIONS--OCB negative clinically definite multiple sclerosis is rare and should be diagnosed with caution; in unequivocal cases it seems to have a relatively benign prognosis.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Disabled Persons</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulins - blood</subject><subject>Immunoglobulins - cerebrospinal fluid</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multiple Sclerosis - classification</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Multiple Sclerosis - immunology</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Oligoclonal Bands</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc9rFDEUx4ModVu9eRUGlPbirElmMkkOHsrSVmFRCkV6C5n82GabSdZkptj_3iy7LG0PJofw8v28x5fvA-ADgnOEmu7rOoTNvCvFHNNXYIbajtVNA29fgxmEGNcNJPAtOM55DbeH8SNwxAhhBZwBel7lcdKPVbRV9G4VlY9B-qqXQVfBrOToHkw1TH50G2-qrLxJMbv8Dryx0mfzfv-egJvLi5vF93r56-rH4nxZ94SisWYWKmS1prpnEOrWGM65Jo1qoSWMSax7ZRFpubQNlxB2ChusiOTlAxnTnIBvu7GbqR-MViaMSXqxSW6Q6VFE6cRzJbg7sYoPomUdYqT0n-77U_wzmTyKwWVlvJfBxCkLSnlX7hb89AJcxymVJLJAlJYIW9zyQn3ZUaqEkJOxBycIiu0yxHYZoiuFwLTgH5-6P8D79Iv-ea_LrKS3SQbl8gHDnHIMYcHqHebyaP4eZJnuRUcbSsTP3wuB4fU1X9JLcVv4sx3fD-v_G_wHx-ivfA</recordid><startdate>199601</startdate><enddate>199601</enddate><creator>Zeman, A Z</creator><creator>Kidd, D</creator><creator>McLean, B N</creator><creator>Kelly, M A</creator><creator>Francis, D A</creator><creator>Miller, D H</creator><creator>Kendall, B E</creator><creator>Rudge, P</creator><creator>Thompson, E J</creator><creator>McDonald, W I</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199601</creationdate><title>A study of oligoclonal band negative multiple sclerosis</title><author>Zeman, A Z ; Kidd, D ; McLean, B N ; Kelly, M A ; Francis, D A ; Miller, D H ; Kendall, B E ; Rudge, P ; Thompson, E J ; McDonald, W I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b571t-8f0c1fdd7db800d4ee999d53c40f588a2dbcf1549af39a006c2e2c5a99af1ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Disabled Persons</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulins - blood</topic><topic>Immunoglobulins - cerebrospinal fluid</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multiple Sclerosis - classification</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Multiple Sclerosis - immunology</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Oligoclonal Bands</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeman, A Z</creatorcontrib><creatorcontrib>Kidd, D</creatorcontrib><creatorcontrib>McLean, B N</creatorcontrib><creatorcontrib>Kelly, M A</creatorcontrib><creatorcontrib>Francis, D A</creatorcontrib><creatorcontrib>Miller, D H</creatorcontrib><creatorcontrib>Kendall, B E</creatorcontrib><creatorcontrib>Rudge, P</creatorcontrib><creatorcontrib>Thompson, E J</creatorcontrib><creatorcontrib>McDonald, W I</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeman, A Z</au><au>Kidd, D</au><au>McLean, B N</au><au>Kelly, M A</au><au>Francis, D A</au><au>Miller, D H</au><au>Kendall, B E</au><au>Rudge, P</au><au>Thompson, E J</au><au>McDonald, W I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A study of oligoclonal band negative multiple sclerosis</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>1996-01</date><risdate>1996</risdate><volume>60</volume><issue>1</issue><spage>27</spage><epage>30</epage><pages>27-30</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>OBJECTIVES--To determine whether oligoclonal band (OCB) negative multiple sclerosis is a reliable diagnosis and, if so, whether it has a distinctive prognosis. METHODS--Retrospective and matched prospective comparison of the clinical and laboratory features of patients with clinical definite multiple sclerosis with and without intrathecal synthesis of oligoclonal IgG. RESULTS--Thirty four patients were identified with apparent OCB negative clinically definite multiple sclerosis. The results of oligoclonal banding proved to have been equivocal in 14 of 34; the clinical diagnosis of multiple sclerosis was questionable in 8 of 34. The remaining 12 patients with "true" OCB negative multiple sclerosis were significantly less disabled than matched OCB positive controls. Re-examination of CSF-serum pairs from six OCB negative patients showed that three remained OCB negative while three showed evidence of intrathecal synthesis of OCBs. CONCLUSIONS--OCB negative clinically definite multiple sclerosis is rare and should be diagnosed with caution; in unequivocal cases it seems to have a relatively benign prognosis.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>8558146</pmid><doi>10.1136/jnnp.60.1.27</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Disabled Persons Female Humans Immunoglobulin G - immunology Immunoglobulins - blood Immunoglobulins - cerebrospinal fluid Magnetic Resonance Imaging Male Medical sciences Multiple Sclerosis - classification Multiple Sclerosis - diagnosis Multiple Sclerosis - immunology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Oligoclonal Bands Prognosis Prospective Studies Reproducibility of Results Retrospective Studies |
| title | A study of oligoclonal band negative multiple sclerosis |
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