Adiponectin is associated with bone strength and fracture history in paralyzed men with spinal cord injury
Summary We explored the association between adiponectin levels and bone strength in paralyzed men with spinal cord injury. We found that bone strength was inversely associated with circulating adiponectin levels. Thus, strength estimates and adiponectin levels may improve fracture risk prediction an...
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| Veröffentlicht in: | Osteoporosis international 2014-11, Vol.25 (11), p.2599-2607 |
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| creator | Tan, C. O. Battaglino, R. A. Doherty, A. L. Gupta, R. Lazzari, A. A. Garshick, E. Zafonte, R. Morse, L. R. |
| description | Summary
We explored the association between adiponectin levels and bone strength in paralyzed men with spinal cord injury. We found that bone strength was inversely associated with circulating adiponectin levels. Thus, strength estimates and adiponectin levels may improve fracture risk prediction and detection of response to osteogenic therapies following spinal cord injury.
Purpose
Previous research has demonstrated an inverse relationship between circulating adiponectin and bone mineral density, suggesting that adiponectin may be used as a biomarker for bone health. However, this relationship may reflect indirect effects on bone metabolism via adipose-mediated mechanical pathways rather than the direct effects of adipokines on bone metabolism. Thus, we explored the association between circulating adiponectin levels and bone strength in 27 men with spinal cord injury.
Methods
Plasma adiponectin levels were quantified by ELISA assay. Axial stiffness and maximal load to fracture of the distal femur were quantified via finite element analysis using reconstructed 3D models of volumetric CT scans. We also collected information on timing, location, and cause of previous fractures.
Results
Axial stiffness and maximal load were inversely associated with circulating adiponectin levels (
R
2
= 0.44,
p
= 0.01;
R
2
= 0.58,
p
= 0.05) after adjusting for injury duration and lower extremity lean mass. In individuals with post-SCI osteoporotic fractures, distal femur stiffness (
p
= 0.01) and maximal load (
p
= 0.005) were lower, and adiponectin was higher (
p
= 0.04) than those with no fracture history.
Conclusions
Based on these findings, strength estimates may improve fracture risk prediction and detection of response to osteogenic therapies following spinal cord injury. Furthermore, our findings suggest that circulating adiponectin may indeed be a feasible biomarker for bone health and osteoporotic fracture risk in paralyzed individuals with spinal cord injury. |
| doi_str_mv | 10.1007/s00198-014-2786-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4861654</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1615260054</sourcerecordid><originalsourceid>FETCH-LOGICAL-c573t-857f8f8cf9507d31d0b8530b8b5357a009638fe19a0bf1ade19be2a47dd004f53</originalsourceid><addsrcrecordid>eNqNkU1rFTEUhoMo9lr9AW5kwI2b0ZOvSbIRSrEqFNwouAuZJHNvLnOTMZmpXH99004tVRDc5IPzvO85yYvQSwxvMYB4VwCwki1g1hIhu5Y8QhvMKG2J6vhjtAFFRasY_n6CnpWyh6pRSjxFJ4QpCVjyDdqfuTCl6O0cYhNKY0pJNpjZu-ZnmHdNX2tNmbOP23oz0TVDNnZesm92ocwpH5sqnEw24_FXFR18XIVlCtGMjU3ZVWK_5ONz9GQwY_Ev7vZT9O3iw9fzT-3ll4-fz88uW8sFnVvJxSAHaQfFQTiKHfSS07r0nHJhAFRH5eCxMtAP2Lh66j0xTDgHwAZOT9H71Xda-oN31se5TqenHA4mH3UyQf9ZiWGnt-lKM9nhjrNq8ObOIKcfiy-zPoRi_Tia6NNSNO4I6YBhrv4DxbyycOv6-i90n5Zc_-iWYrTjQnSVwitlcyol--F-bgz6JnS9hq5r6PomdE2q5tXDB98rfqdcAbICpZbi1ucHrf_peg1oX7kr</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1614365776</pqid></control><display><type>article</type><title>Adiponectin is associated with bone strength and fracture history in paralyzed men with spinal cord injury</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Tan, C. O. ; Battaglino, R. A. ; Doherty, A. L. ; Gupta, R. ; Lazzari, A. A. ; Garshick, E. ; Zafonte, R. ; Morse, L. R.</creator><creatorcontrib>Tan, C. O. ; Battaglino, R. A. ; Doherty, A. L. ; Gupta, R. ; Lazzari, A. A. ; Garshick, E. ; Zafonte, R. ; Morse, L. R.</creatorcontrib><description>Summary
We explored the association between adiponectin levels and bone strength in paralyzed men with spinal cord injury. We found that bone strength was inversely associated with circulating adiponectin levels. Thus, strength estimates and adiponectin levels may improve fracture risk prediction and detection of response to osteogenic therapies following spinal cord injury.
Purpose
Previous research has demonstrated an inverse relationship between circulating adiponectin and bone mineral density, suggesting that adiponectin may be used as a biomarker for bone health. However, this relationship may reflect indirect effects on bone metabolism via adipose-mediated mechanical pathways rather than the direct effects of adipokines on bone metabolism. Thus, we explored the association between circulating adiponectin levels and bone strength in 27 men with spinal cord injury.
Methods
Plasma adiponectin levels were quantified by ELISA assay. Axial stiffness and maximal load to fracture of the distal femur were quantified via finite element analysis using reconstructed 3D models of volumetric CT scans. We also collected information on timing, location, and cause of previous fractures.
Results
Axial stiffness and maximal load were inversely associated with circulating adiponectin levels (
R
2
= 0.44,
p
= 0.01;
R
2
= 0.58,
p
= 0.05) after adjusting for injury duration and lower extremity lean mass. In individuals with post-SCI osteoporotic fractures, distal femur stiffness (
p
= 0.01) and maximal load (
p
= 0.005) were lower, and adiponectin was higher (
p
= 0.04) than those with no fracture history.
Conclusions
Based on these findings, strength estimates may improve fracture risk prediction and detection of response to osteogenic therapies following spinal cord injury. Furthermore, our findings suggest that circulating adiponectin may indeed be a feasible biomarker for bone health and osteoporotic fracture risk in paralyzed individuals with spinal cord injury.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-014-2786-2</identifier><identifier>PMID: 24980185</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Absorptiometry, Photon - methods ; Adiponectin - blood ; Adiponectin - physiology ; Adult ; Biomarkers ; Biomarkers - blood ; Bone Density - physiology ; Bones ; Endocrinology ; Femur - physiopathology ; Finite Element Analysis ; Fractures ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Orthopedics ; Osteoporotic Fractures - blood ; Osteoporotic Fractures - etiology ; Osteoporotic Fractures - physiopathology ; Paralysis ; Paraplegia - blood ; Paraplegia - complications ; Paraplegia - physiopathology ; Polypeptides ; Rheumatology ; Risk assessment ; Risk Factors ; Spinal cord injuries ; Spinal Cord Injuries - blood ; Spinal Cord Injuries - complications ; Spinal Cord Injuries - physiopathology ; Tomography, X-Ray Computed - methods ; Weight-Bearing - physiology ; Young Adult</subject><ispartof>Osteoporosis international, 2014-11, Vol.25 (11), p.2599-2607</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-857f8f8cf9507d31d0b8530b8b5357a009638fe19a0bf1ade19be2a47dd004f53</citedby><cites>FETCH-LOGICAL-c573t-857f8f8cf9507d31d0b8530b8b5357a009638fe19a0bf1ade19be2a47dd004f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-014-2786-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-014-2786-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24980185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, C. O.</creatorcontrib><creatorcontrib>Battaglino, R. A.</creatorcontrib><creatorcontrib>Doherty, A. L.</creatorcontrib><creatorcontrib>Gupta, R.</creatorcontrib><creatorcontrib>Lazzari, A. A.</creatorcontrib><creatorcontrib>Garshick, E.</creatorcontrib><creatorcontrib>Zafonte, R.</creatorcontrib><creatorcontrib>Morse, L. R.</creatorcontrib><title>Adiponectin is associated with bone strength and fracture history in paralyzed men with spinal cord injury</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary
We explored the association between adiponectin levels and bone strength in paralyzed men with spinal cord injury. We found that bone strength was inversely associated with circulating adiponectin levels. Thus, strength estimates and adiponectin levels may improve fracture risk prediction and detection of response to osteogenic therapies following spinal cord injury.
Purpose
Previous research has demonstrated an inverse relationship between circulating adiponectin and bone mineral density, suggesting that adiponectin may be used as a biomarker for bone health. However, this relationship may reflect indirect effects on bone metabolism via adipose-mediated mechanical pathways rather than the direct effects of adipokines on bone metabolism. Thus, we explored the association between circulating adiponectin levels and bone strength in 27 men with spinal cord injury.
Methods
Plasma adiponectin levels were quantified by ELISA assay. Axial stiffness and maximal load to fracture of the distal femur were quantified via finite element analysis using reconstructed 3D models of volumetric CT scans. We also collected information on timing, location, and cause of previous fractures.
Results
Axial stiffness and maximal load were inversely associated with circulating adiponectin levels (
R
2
= 0.44,
p
= 0.01;
R
2
= 0.58,
p
= 0.05) after adjusting for injury duration and lower extremity lean mass. In individuals with post-SCI osteoporotic fractures, distal femur stiffness (
p
= 0.01) and maximal load (
p
= 0.005) were lower, and adiponectin was higher (
p
= 0.04) than those with no fracture history.
Conclusions
Based on these findings, strength estimates may improve fracture risk prediction and detection of response to osteogenic therapies following spinal cord injury. Furthermore, our findings suggest that circulating adiponectin may indeed be a feasible biomarker for bone health and osteoporotic fracture risk in paralyzed individuals with spinal cord injury.</description><subject>Absorptiometry, Photon - methods</subject><subject>Adiponectin - blood</subject><subject>Adiponectin - physiology</subject><subject>Adult</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Bone Density - physiology</subject><subject>Bones</subject><subject>Endocrinology</subject><subject>Femur - physiopathology</subject><subject>Finite Element Analysis</subject><subject>Fractures</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoporotic Fractures - blood</subject><subject>Osteoporotic Fractures - etiology</subject><subject>Osteoporotic Fractures - physiopathology</subject><subject>Paralysis</subject><subject>Paraplegia - blood</subject><subject>Paraplegia - complications</subject><subject>Paraplegia - physiopathology</subject><subject>Polypeptides</subject><subject>Rheumatology</subject><subject>Risk assessment</subject><subject>Risk Factors</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - blood</subject><subject>Spinal Cord Injuries - complications</subject><subject>Spinal Cord Injuries - physiopathology</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Weight-Bearing - physiology</subject><subject>Young Adult</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU1rFTEUhoMo9lr9AW5kwI2b0ZOvSbIRSrEqFNwouAuZJHNvLnOTMZmpXH99004tVRDc5IPzvO85yYvQSwxvMYB4VwCwki1g1hIhu5Y8QhvMKG2J6vhjtAFFRasY_n6CnpWyh6pRSjxFJ4QpCVjyDdqfuTCl6O0cYhNKY0pJNpjZu-ZnmHdNX2tNmbOP23oz0TVDNnZesm92ocwpH5sqnEw24_FXFR18XIVlCtGMjU3ZVWK_5ONz9GQwY_Ev7vZT9O3iw9fzT-3ll4-fz88uW8sFnVvJxSAHaQfFQTiKHfSS07r0nHJhAFRH5eCxMtAP2Lh66j0xTDgHwAZOT9H71Xda-oN31se5TqenHA4mH3UyQf9ZiWGnt-lKM9nhjrNq8ObOIKcfiy-zPoRi_Tia6NNSNO4I6YBhrv4DxbyycOv6-i90n5Zc_-iWYrTjQnSVwitlcyol--F-bgz6JnS9hq5r6PomdE2q5tXDB98rfqdcAbICpZbi1ucHrf_peg1oX7kr</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Tan, C. O.</creator><creator>Battaglino, R. A.</creator><creator>Doherty, A. L.</creator><creator>Gupta, R.</creator><creator>Lazzari, A. A.</creator><creator>Garshick, E.</creator><creator>Zafonte, R.</creator><creator>Morse, L. R.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141101</creationdate><title>Adiponectin is associated with bone strength and fracture history in paralyzed men with spinal cord injury</title><author>Tan, C. O. ; Battaglino, R. A. ; Doherty, A. L. ; Gupta, R. ; Lazzari, A. A. ; Garshick, E. ; Zafonte, R. ; Morse, L. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-857f8f8cf9507d31d0b8530b8b5357a009638fe19a0bf1ade19be2a47dd004f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Absorptiometry, Photon - methods</topic><topic>Adiponectin - blood</topic><topic>Adiponectin - physiology</topic><topic>Adult</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Bone Density - physiology</topic><topic>Bones</topic><topic>Endocrinology</topic><topic>Femur - physiopathology</topic><topic>Finite Element Analysis</topic><topic>Fractures</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteoporotic Fractures - blood</topic><topic>Osteoporotic Fractures - etiology</topic><topic>Osteoporotic Fractures - physiopathology</topic><topic>Paralysis</topic><topic>Paraplegia - blood</topic><topic>Paraplegia - complications</topic><topic>Paraplegia - physiopathology</topic><topic>Polypeptides</topic><topic>Rheumatology</topic><topic>Risk assessment</topic><topic>Risk Factors</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - blood</topic><topic>Spinal Cord Injuries - complications</topic><topic>Spinal Cord Injuries - physiopathology</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Weight-Bearing - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, C. O.</creatorcontrib><creatorcontrib>Battaglino, R. A.</creatorcontrib><creatorcontrib>Doherty, A. L.</creatorcontrib><creatorcontrib>Gupta, R.</creatorcontrib><creatorcontrib>Lazzari, A. A.</creatorcontrib><creatorcontrib>Garshick, E.</creatorcontrib><creatorcontrib>Zafonte, R.</creatorcontrib><creatorcontrib>Morse, L. R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, C. O.</au><au>Battaglino, R. A.</au><au>Doherty, A. L.</au><au>Gupta, R.</au><au>Lazzari, A. A.</au><au>Garshick, E.</au><au>Zafonte, R.</au><au>Morse, L. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adiponectin is associated with bone strength and fracture history in paralyzed men with spinal cord injury</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>25</volume><issue>11</issue><spage>2599</spage><epage>2607</epage><pages>2599-2607</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary
We explored the association between adiponectin levels and bone strength in paralyzed men with spinal cord injury. We found that bone strength was inversely associated with circulating adiponectin levels. Thus, strength estimates and adiponectin levels may improve fracture risk prediction and detection of response to osteogenic therapies following spinal cord injury.
Purpose
Previous research has demonstrated an inverse relationship between circulating adiponectin and bone mineral density, suggesting that adiponectin may be used as a biomarker for bone health. However, this relationship may reflect indirect effects on bone metabolism via adipose-mediated mechanical pathways rather than the direct effects of adipokines on bone metabolism. Thus, we explored the association between circulating adiponectin levels and bone strength in 27 men with spinal cord injury.
Methods
Plasma adiponectin levels were quantified by ELISA assay. Axial stiffness and maximal load to fracture of the distal femur were quantified via finite element analysis using reconstructed 3D models of volumetric CT scans. We also collected information on timing, location, and cause of previous fractures.
Results
Axial stiffness and maximal load were inversely associated with circulating adiponectin levels (
R
2
= 0.44,
p
= 0.01;
R
2
= 0.58,
p
= 0.05) after adjusting for injury duration and lower extremity lean mass. In individuals with post-SCI osteoporotic fractures, distal femur stiffness (
p
= 0.01) and maximal load (
p
= 0.005) were lower, and adiponectin was higher (
p
= 0.04) than those with no fracture history.
Conclusions
Based on these findings, strength estimates may improve fracture risk prediction and detection of response to osteogenic therapies following spinal cord injury. Furthermore, our findings suggest that circulating adiponectin may indeed be a feasible biomarker for bone health and osteoporotic fracture risk in paralyzed individuals with spinal cord injury.</abstract><cop>London</cop><pub>Springer London</pub><pmid>24980185</pmid><doi>10.1007/s00198-014-2786-2</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0937-941X |
| ispartof | Osteoporosis international, 2014-11, Vol.25 (11), p.2599-2607 |
| issn | 0937-941X 1433-2965 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4861654 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Absorptiometry, Photon - methods Adiponectin - blood Adiponectin - physiology Adult Biomarkers Biomarkers - blood Bone Density - physiology Bones Endocrinology Femur - physiopathology Finite Element Analysis Fractures Humans Male Medicine Medicine & Public Health Middle Aged Original Article Orthopedics Osteoporotic Fractures - blood Osteoporotic Fractures - etiology Osteoporotic Fractures - physiopathology Paralysis Paraplegia - blood Paraplegia - complications Paraplegia - physiopathology Polypeptides Rheumatology Risk assessment Risk Factors Spinal cord injuries Spinal Cord Injuries - blood Spinal Cord Injuries - complications Spinal Cord Injuries - physiopathology Tomography, X-Ray Computed - methods Weight-Bearing - physiology Young Adult |
| title | Adiponectin is associated with bone strength and fracture history in paralyzed men with spinal cord injury |
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