Membrane Localization of Human Equilibrative Nucleoside Transporter 1 in Tumor Cells May Predict Response to Adjuvant Gemcitabine in Resected Cholangiocarcinoma Patients

Background. The use of gemcitabine as an adjuvant modality for cholangiocarcinoma (CC) is increasing, but limited data are available on predictive biomarkers of response. Human equilibrative nucleoside transporter 1 (hENT‐1) is the major transporter involved in gemcitabine intracellular uptake. This...

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Veröffentlicht in:	The oncologist (Dayton, Ohio) Ohio), 2016-05, Vol.21 (5), p.600-607
Hauptverfasser:	Brandi, Giovanni, Deserti, Marzia, Vasuri, Francesco, Farioli, Andrea, Degiovanni, Alessio, Palloni, Andrea, Frega, Giorgio, Barbera, Maria A., Lorenzo, Stefania, Garajova, Ingrid, Di Marco, Mariacristina, Pinna, Antonio D., Cescon, Matteo, Cucchetti, Alessandro, Ercolani, Giorgio, D'Errico‐Grigioni, Antonietta, Pantaleo, Maria A., Biasco, Guido, Tavolari, Simona, Aprile, Guiseppe, Cereda, Stefano, Fornaro, Lorenzo, Leone, Francesco, Lonardi, Sara, Santini, Daniele, Silvestris, Nicola, Vasile, Enrico
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant gemcitabine Aged Antimetabolites, Antineoplastic - therapeutic use Bile Duct Neoplasms - chemistry Bile Duct Neoplasms - drug therapy Bile Duct Neoplasms - mortality Bile Duct Neoplasms - surgery Chemotherapy, Adjuvant Cholangiocarcinoma Cholangiocarcinoma - chemistry Cholangiocarcinoma - drug therapy Cholangiocarcinoma - mortality Cholangiocarcinoma - surgery Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Disease-Free Survival Equilibrative Nucleoside Transporter 1 - analysis Female Hepatobiliary Human equilibrative nucleoside transporter 1 Humans Male Middle Aged Predictive biomarkers of response to chemotherapy
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