Coalescence of deep and superficial epileptic foci into larger discharge units in adult rat neocortex
Highlights • Multiple electrode arrays were used to characterize epileptic discharges in adult rat somatosensory cortex slices. • Data show that an epileptic focus consists of multiple, small, discreet firing units over several cortical layers. • During the recording these gradually become coupled,...
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| Veröffentlicht in: | Neuroscience 2015-04, Vol.292, p.148-158 |
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| container_title | Neuroscience |
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| creator | Serafini, Ruggero Andrade, Rodrigo Loeb, Jeffrey A |
| description | Highlights • Multiple electrode arrays were used to characterize epileptic discharges in adult rat somatosensory cortex slices. • Data show that an epileptic focus consists of multiple, small, discreet firing units over several cortical layers. • During the recording these gradually become coupled, coalescing into larger coherent units. • These findings illustrate an emerging network property in the development of an epileptic focus. |
| doi_str_mv | 10.1016/j.neuroscience.2015.02.017 |
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| identifier | ISSN: 0306-4522 |
| ispartof | Neuroscience, 2015-04, Vol.292, p.148-158 |
| issn | 0306-4522 1873-7544 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4860900 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 4-Aminopyridine Animals early development of a focus Epilepsy - physiopathology epileptic discharges Equipment Design Magnesium Deficiency Microelectrodes neocortical focus Neurology Rats Somatosensory Cortex - physiopathology Tissue Culture Techniques |
| title | Coalescence of deep and superficial epileptic foci into larger discharge units in adult rat neocortex |
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