Efficacy of Antibody Delivery to the Retina and Optic Nerve by Topical Administration

The purpose of this study was to determine whether nonspecific and ICAM-1-specific IgG1 antibodies can accumulate in the rat retina following topical application, and to develop a model system to show that antibodies that reach the posterior segment retain their pharmacological properties. Eye drops...

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Veröffentlicht in:	Journal of ocular pharmacology and therapeutics 2016-05, Vol.32 (4), p.203-210
Hauptverfasser:	Hu, Stacy, Koevary, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Cell Proliferation - drug effects Female Human Umbilical Vein Endothelial Cells - drug effects Humans Immunoglobulin G - administration & dosage Immunoglobulin G - metabolism Immunoglobulin G - pharmacology Optic Nerve - immunology Optic Nerve - metabolism Original Rats Rats, Inbred Lew Retina - immunology Retina - metabolism
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