In vitro and in vivo antiangiogenic activity of desacetylvinblastine monohydrazide through inhibition of VEGFR2 and Axl pathways

Tumor angiogenic process is regulated by multiple proangiogenic pathways, such as vascular endothelial growth factor receptor 2 (VEGFR2) and Axl receptor tyrosine kinase (Axl). Axl is one of many important factors involved in anti-VEGF resistance. Inhibition of VEGF/VEGFR2 signaling pathway alone fa...

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Veröffentlicht in:American journal of cancer research 2016-01, Vol.6 (4), p.843-858
Hauptverfasser: Lei, Xueping, Chen, Minfeng, Nie, Qiulin, Hu, Jianyang, Zhuo, Zhenjian, Yiu, Anita, Chen, Heru, Xu, Nanhui, Huang, Maohua, Ye, Kaihe, Bai, Liangliang, Ye, Wencai, Zhang, Dongmei
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Sprache:eng
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