ImmunoPET of murine T cell reconstitution post-adoptive stem cell transplant using anti-CD4 and anti-CD8 cys-diabodies

The proliferation and trafficking of T lymphocytes in immune responses are crucial events in determining inflammatory responses. To study whole body T lymphocyte dynamics non-invasively in vivo, we have generated anti-CD4 and -CD8 cys-diabodies (cDbs) derived from the parental antibody hybridomas GK...

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Veröffentlicht in:The Journal of nuclear medicine (1978) 2015-05, Vol.56 (8), p.1258-1264
Hauptverfasser: Tavaré, Richard, McCracken, Melissa N., Zettlitz, Kirstin A., Salazar, Felix B., Olafsen, Tove, Witte, Owen N., Wu, Anna M.
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container_end_page 1264
container_issue 8
container_start_page 1258
container_title The Journal of nuclear medicine (1978)
container_volume 56
creator Tavaré, Richard
McCracken, Melissa N.
Zettlitz, Kirstin A.
Salazar, Felix B.
Olafsen, Tove
Witte, Owen N.
Wu, Anna M.
description The proliferation and trafficking of T lymphocytes in immune responses are crucial events in determining inflammatory responses. To study whole body T lymphocyte dynamics non-invasively in vivo, we have generated anti-CD4 and -CD8 cys-diabodies (cDbs) derived from the parental antibody hybridomas GK1.5 and 2.43, respectively, for 89 Zr-immunoPET detection of helper and cytotoxic T cell populations.
doi_str_mv 10.2967/jnumed.114.153338
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title ImmunoPET of murine T cell reconstitution post-adoptive stem cell transplant using anti-CD4 and anti-CD8 cys-diabodies
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