Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells

The potential antitumor activity of cannabinoid receptor agonists, such as the aminoalklylindole WIN55,212-2 (WIN2), has been studied extensively, but their potential interaction with conventional cancer therapies, such as radiation, remains unknown. In the present work, the influence of WIN2 on the...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2014-02, Vol.348 (2), p.293-302
Hauptverfasser:	Emery, Sean M, Alotaibi, Moureq R, Tao, Qing, Selley, Dana E, Lichtman, Aron H, Gewirtz, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Autophagy - drug effects Autophagy - radiation effects Benzoxazines - chemistry Benzoxazines - pharmacology Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - radiotherapy Cannabinoid Receptor Agonists - chemistry Cannabinoid Receptor Agonists - pharmacology Cannabinoids - chemistry Cannabinoids - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - radiation effects Cellular Senescence - drug effects Cellular Senescence - radiation effects Chemotherapy, Antibiotics, and Gene Therapy Female Gene Expression Regulation, Neoplastic - drug effects Humans Lysophospholipids - antagonists & inhibitors Lysophospholipids - metabolism Mice Morpholines - chemistry Morpholines - pharmacology Naphthalenes - chemistry Naphthalenes - pharmacology Neoplasm Proteins - agonists Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Phytochemicals - chemistry Phytochemicals - pharmacology Receptors, Cannabinoid - chemistry Receptors, Cannabinoid - genetics Receptors, Cannabinoid - metabolism Sphingosine - analogs & derivatives Sphingosine - antagonists & inhibitors Sphingosine - metabolism Stereoisomerism
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