Pulmonary Mycobacterium avium-intracellulare is the main driver of the rise in non-tuberculous mycobacteria incidence in England, Wales and Northern Ireland, 2007-2012
The incidence of non-tuberculous mycobacteria (NTM) isolation from humans is increasing worldwide. In England, Wales and Northern Ireland (EW&NI) the reported rate of NTM more than doubled between 1996 and 2006. Although NTM infection has traditionally been associated with immunosuppressed indiv...
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| Veröffentlicht in: | BMC infectious diseases 2016-05, Vol.16 (190), p.195, Article 195 |
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| creator | Shah, Neeraj M Davidson, Jennifer A Anderson, Laura F Lalor, Maeve K Kim, Jusang Thomas, H Lucy Lipman, Marc Abubakar, Ibrahim |
| description | The incidence of non-tuberculous mycobacteria (NTM) isolation from humans is increasing worldwide. In England, Wales and Northern Ireland (EW&NI) the reported rate of NTM more than doubled between 1996 and 2006. Although NTM infection has traditionally been associated with immunosuppressed individuals or those with severe underlying lung damage, pulmonary NTM infection and disease may occur in people with no overt immune deficiency. Here we report the incidence of NTM isolation in EW&NI between 2007 and 2012 from both pulmonary and extra-pulmonary samples obtained at a population level.
All individuals with culture positive NTM isolates between 2007 and 2012 reported to Public Health England by the five mycobacterial reference laboratories serving EW&NI were included.
Between 2007 and 2012, 21,118 individuals had NTM culture positive isolates. Over the study period the incidence rose from 5.6/100,000 in 2007 to 7.6/100,000 in 2012 (p |
| doi_str_mv | 10.1186/s12879-016-1521-3 |
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All individuals with culture positive NTM isolates between 2007 and 2012 reported to Public Health England by the five mycobacterial reference laboratories serving EW&NI were included.
Between 2007 and 2012, 21,118 individuals had NTM culture positive isolates. Over the study period the incidence rose from 5.6/100,000 in 2007 to 7.6/100,000 in 2012 (p < 0.001). Of those with a known specimen type, 90 % were pulmonary, in whom incidence increased from 4.0/100,000 to 6.1/100,000 (p < 0.001). In extra-pulmonary specimens this fell from 0.6/100,000 to 0.4/100,000 (p < 0.001). The most frequently cultured organisms from individuals with pulmonary isolates were within the M. avium-intracellulare complex family (MAC). The incidence of pulmonary MAC increased from 1.3/100,000 to 2.2/100,000 (p < 0.001). The majority of these individuals were over 60 years old.
Using a population-based approach, we find that the incidence of NTM has continued to rise since the last national analysis. Overall, this represents an almost ten-fold increase since 1995. Pulmonary MAC in older individuals is responsible for the majority of this change. We are limited to reporting NTM isolates and not clinical disease caused by these organisms. To determine whether the burden of NTM disease is genuinely increasing, a standardised approach to the collection of linked national microbiological and clinical data is required.]]></description><identifier>ISSN: 1471-2334</identifier><identifier>EISSN: 1471-2334</identifier><identifier>DOI: 10.1186/s12879-016-1521-3</identifier><identifier>PMID: 27154015</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Aged ; Analysis ; Care and treatment ; Complications and side effects ; England ; Female ; Humans ; Immunodeficiency ; Immunologic Deficiency Syndromes ; Immunosuppressive Agents ; Infectious diseases ; Lung Diseases - epidemiology ; Lung Diseases - microbiology ; Male ; Middle Aged ; Mycobacteria ; Mycobacterium ; Mycobacterium avium Complex - pathogenicity ; Mycobacterium avium-intracellulare Infection - epidemiology ; Mycobacterium avium-intracellulare Infection - microbiology ; Mycobacterium Infections, Nontuberculous - epidemiology ; Mycobacterium Infections, Nontuberculous - microbiology ; Northern Ireland - epidemiology ; Physiological aspects ; Tuberculosis ; Wales - epidemiology</subject><ispartof>BMC infectious diseases, 2016-05, Vol.16 (190), p.195, Article 195</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>Shah et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c595t-541735517d96e4ad9e73ae381b4f4c06075532ac1ab367dd1ee82c798c19d8ac3</citedby><cites>FETCH-LOGICAL-c595t-541735517d96e4ad9e73ae381b4f4c06075532ac1ab367dd1ee82c798c19d8ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858927/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858927/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27154015$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shah, Neeraj M</creatorcontrib><creatorcontrib>Davidson, Jennifer A</creatorcontrib><creatorcontrib>Anderson, Laura F</creatorcontrib><creatorcontrib>Lalor, Maeve K</creatorcontrib><creatorcontrib>Kim, Jusang</creatorcontrib><creatorcontrib>Thomas, H Lucy</creatorcontrib><creatorcontrib>Lipman, Marc</creatorcontrib><creatorcontrib>Abubakar, Ibrahim</creatorcontrib><title>Pulmonary Mycobacterium avium-intracellulare is the main driver of the rise in non-tuberculous mycobacteria incidence in England, Wales and Northern Ireland, 2007-2012</title><title>BMC infectious diseases</title><addtitle>BMC Infect Dis</addtitle><description><![CDATA[The incidence of non-tuberculous mycobacteria (NTM) isolation from humans is increasing worldwide. In England, Wales and Northern Ireland (EW&NI) the reported rate of NTM more than doubled between 1996 and 2006. Although NTM infection has traditionally been associated with immunosuppressed individuals or those with severe underlying lung damage, pulmonary NTM infection and disease may occur in people with no overt immune deficiency. Here we report the incidence of NTM isolation in EW&NI between 2007 and 2012 from both pulmonary and extra-pulmonary samples obtained at a population level.
All individuals with culture positive NTM isolates between 2007 and 2012 reported to Public Health England by the five mycobacterial reference laboratories serving EW&NI were included.
Between 2007 and 2012, 21,118 individuals had NTM culture positive isolates. Over the study period the incidence rose from 5.6/100,000 in 2007 to 7.6/100,000 in 2012 (p < 0.001). Of those with a known specimen type, 90 % were pulmonary, in whom incidence increased from 4.0/100,000 to 6.1/100,000 (p < 0.001). In extra-pulmonary specimens this fell from 0.6/100,000 to 0.4/100,000 (p < 0.001). The most frequently cultured organisms from individuals with pulmonary isolates were within the M. avium-intracellulare complex family (MAC). The incidence of pulmonary MAC increased from 1.3/100,000 to 2.2/100,000 (p < 0.001). The majority of these individuals were over 60 years old.
Using a population-based approach, we find that the incidence of NTM has continued to rise since the last national analysis. Overall, this represents an almost ten-fold increase since 1995. Pulmonary MAC in older individuals is responsible for the majority of this change. We are limited to reporting NTM isolates and not clinical disease caused by these organisms. To determine whether the burden of NTM disease is genuinely increasing, a standardised approach to the collection of linked national microbiological and clinical data is required.]]></description><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>England</subject><subject>Female</subject><subject>Humans</subject><subject>Immunodeficiency</subject><subject>Immunologic Deficiency Syndromes</subject><subject>Immunosuppressive Agents</subject><subject>Infectious diseases</subject><subject>Lung Diseases - epidemiology</subject><subject>Lung Diseases - microbiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mycobacteria</subject><subject>Mycobacterium</subject><subject>Mycobacterium avium Complex - pathogenicity</subject><subject>Mycobacterium avium-intracellulare Infection - epidemiology</subject><subject>Mycobacterium avium-intracellulare Infection - microbiology</subject><subject>Mycobacterium Infections, Nontuberculous - epidemiology</subject><subject>Mycobacterium Infections, Nontuberculous - microbiology</subject><subject>Northern Ireland - epidemiology</subject><subject>Physiological aspects</subject><subject>Tuberculosis</subject><subject>Wales - epidemiology</subject><issn>1471-2334</issn><issn>1471-2334</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNUl1rFDEUHUSxtfoDfJGAT4JTc5PJJPMilFLrQrXi52PIZu5sU2aSNplZ2l_k3zTTrW0XfJCQ5JJz7iH3cIriJdB9AFW_S8CUbEoKdQmCQckfFbtQSSgZ59XjB_VO8Sylc0pBKtY8LXaYBFFRELvF7y9TPwRv4jX5dG3D0tgRo5sGYtb5LJ0fo7HY91NvIhKXyHiGZDDOkza6NUYSupun6FKGPfHBl-O0xGinPkyJDPeiJuPWtejtDfPIr3rj27fkl-kxkVySzyFmrejJIuIGY5TKklFgz4snnekTvri994ofH46-H34sT06PF4cHJ6UVjRhLUYHkQoBsmxor0zYouUGuYFl1laU1lUJwZiyYJa9l2wKiYlY2ykLTKmP5XvF-o3sxLQdsLc4G9PoiuiF7pINxehvx7kyvwlpXSqiGySzw-lYghssJ06jPwxR9_rMG2UjOVNXwe9YqD6-d78Ls8-CS1QeVgDpvRTNr_x-svFocnA0eO5fftxrebDVkzohX48pMKenFt6__zz39uc2FDdfGkFLE7s4QoHqOot5EUeco6jmKeh7x1UMn7zr-Zo__AXQN2Lk</recordid><startdate>20160506</startdate><enddate>20160506</enddate><creator>Shah, Neeraj M</creator><creator>Davidson, Jennifer A</creator><creator>Anderson, Laura F</creator><creator>Lalor, Maeve K</creator><creator>Kim, Jusang</creator><creator>Thomas, H Lucy</creator><creator>Lipman, Marc</creator><creator>Abubakar, Ibrahim</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7T2</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope></search><sort><creationdate>20160506</creationdate><title>Pulmonary Mycobacterium avium-intracellulare is the main driver of the rise in non-tuberculous mycobacteria incidence in England, Wales and Northern Ireland, 2007-2012</title><author>Shah, Neeraj M ; Davidson, Jennifer A ; Anderson, Laura F ; Lalor, Maeve K ; Kim, Jusang ; Thomas, H Lucy ; Lipman, Marc ; Abubakar, Ibrahim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c595t-541735517d96e4ad9e73ae381b4f4c06075532ac1ab367dd1ee82c798c19d8ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>England</topic><topic>Female</topic><topic>Humans</topic><topic>Immunodeficiency</topic><topic>Immunologic Deficiency Syndromes</topic><topic>Immunosuppressive Agents</topic><topic>Infectious diseases</topic><topic>Lung Diseases - epidemiology</topic><topic>Lung Diseases - microbiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mycobacteria</topic><topic>Mycobacterium</topic><topic>Mycobacterium avium Complex - pathogenicity</topic><topic>Mycobacterium avium-intracellulare Infection - epidemiology</topic><topic>Mycobacterium avium-intracellulare Infection - microbiology</topic><topic>Mycobacterium Infections, Nontuberculous - epidemiology</topic><topic>Mycobacterium Infections, Nontuberculous - microbiology</topic><topic>Northern Ireland - epidemiology</topic><topic>Physiological aspects</topic><topic>Tuberculosis</topic><topic>Wales - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shah, Neeraj M</creatorcontrib><creatorcontrib>Davidson, Jennifer A</creatorcontrib><creatorcontrib>Anderson, Laura F</creatorcontrib><creatorcontrib>Lalor, Maeve K</creatorcontrib><creatorcontrib>Kim, Jusang</creatorcontrib><creatorcontrib>Thomas, H Lucy</creatorcontrib><creatorcontrib>Lipman, Marc</creatorcontrib><creatorcontrib>Abubakar, Ibrahim</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shah, Neeraj M</au><au>Davidson, Jennifer A</au><au>Anderson, Laura F</au><au>Lalor, Maeve K</au><au>Kim, Jusang</au><au>Thomas, H Lucy</au><au>Lipman, Marc</au><au>Abubakar, Ibrahim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary Mycobacterium avium-intracellulare is the main driver of the rise in non-tuberculous mycobacteria incidence in England, Wales and Northern Ireland, 2007-2012</atitle><jtitle>BMC infectious diseases</jtitle><addtitle>BMC Infect Dis</addtitle><date>2016-05-06</date><risdate>2016</risdate><volume>16</volume><issue>190</issue><spage>195</spage><pages>195-</pages><artnum>195</artnum><issn>1471-2334</issn><eissn>1471-2334</eissn><abstract><![CDATA[The incidence of non-tuberculous mycobacteria (NTM) isolation from humans is increasing worldwide. In England, Wales and Northern Ireland (EW&NI) the reported rate of NTM more than doubled between 1996 and 2006. Although NTM infection has traditionally been associated with immunosuppressed individuals or those with severe underlying lung damage, pulmonary NTM infection and disease may occur in people with no overt immune deficiency. Here we report the incidence of NTM isolation in EW&NI between 2007 and 2012 from both pulmonary and extra-pulmonary samples obtained at a population level.
All individuals with culture positive NTM isolates between 2007 and 2012 reported to Public Health England by the five mycobacterial reference laboratories serving EW&NI were included.
Between 2007 and 2012, 21,118 individuals had NTM culture positive isolates. Over the study period the incidence rose from 5.6/100,000 in 2007 to 7.6/100,000 in 2012 (p < 0.001). Of those with a known specimen type, 90 % were pulmonary, in whom incidence increased from 4.0/100,000 to 6.1/100,000 (p < 0.001). In extra-pulmonary specimens this fell from 0.6/100,000 to 0.4/100,000 (p < 0.001). The most frequently cultured organisms from individuals with pulmonary isolates were within the M. avium-intracellulare complex family (MAC). The incidence of pulmonary MAC increased from 1.3/100,000 to 2.2/100,000 (p < 0.001). The majority of these individuals were over 60 years old.
Using a population-based approach, we find that the incidence of NTM has continued to rise since the last national analysis. Overall, this represents an almost ten-fold increase since 1995. Pulmonary MAC in older individuals is responsible for the majority of this change. We are limited to reporting NTM isolates and not clinical disease caused by these organisms. To determine whether the burden of NTM disease is genuinely increasing, a standardised approach to the collection of linked national microbiological and clinical data is required.]]></abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27154015</pmid><doi>10.1186/s12879-016-1521-3</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Analysis Care and treatment Complications and side effects England Female Humans Immunodeficiency Immunologic Deficiency Syndromes Immunosuppressive Agents Infectious diseases Lung Diseases - epidemiology Lung Diseases - microbiology Male Middle Aged Mycobacteria Mycobacterium Mycobacterium avium Complex - pathogenicity Mycobacterium avium-intracellulare Infection - epidemiology Mycobacterium avium-intracellulare Infection - microbiology Mycobacterium Infections, Nontuberculous - epidemiology Mycobacterium Infections, Nontuberculous - microbiology Northern Ireland - epidemiology Physiological aspects Tuberculosis Wales - epidemiology |
| title | Pulmonary Mycobacterium avium-intracellulare is the main driver of the rise in non-tuberculous mycobacteria incidence in England, Wales and Northern Ireland, 2007-2012 |
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