Histamine 1 receptor-Gβγ-cAMP/PKA-CFTR pathway mediates the histamine-induced resetting of the suprachiasmatic circadian clock

Recent evidence indicates that histamine, acting on histamine 1 receptor (H1R), resets the circadian clock in the mouse suprachiasmatic nucleus (SCN) by increasing intracellular Ca(2+) concentration ([Ca(2+)]i) through the activation of CaV1.3 L-type Ca(2+) channels and Ca(2+)-induced Ca(2+) release...

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Veröffentlicht in:	Molecular brain 2016-05, Vol.9 (1), p.49-49, Article 49
Hauptverfasser:	Kim, Yoon Sik, Kim, Young-Beom, Kim, Woong Bin, Lee, Seung Won, Oh, Seog Bae, Han, Hee-Chul, Lee, C Justin, Colwell, Christopher S, Kim, Yang In
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Channels, L-Type - metabolism Chlorides - metabolism Circadian Clocks - drug effects Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Cystic Fibrosis Transmembrane Conductance Regulator - metabolism GTP-Binding Protein beta Subunits - metabolism GTP-Binding Protein gamma Subunits - metabolism Histamine - pharmacology Ion Channel Gating - drug effects Male Mice, Inbred C57BL Models, Biological Neurons - drug effects Neurons - metabolism Receptors, Histamine H1 - metabolism Signal Transduction - drug effects Solute Carrier Family 12, Member 2 - metabolism Suprachiasmatic Nucleus - metabolism
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