Multiple Hypersensitivities Including Recurrent Airway Obstruction, Insect Bite Hypersensitivity, and Urticaria in 2 Warmblood Horse Populations
Background Multiple hypersensitivities (MHS) have been described in humans, cats, and dogs, but not horses. Hypotheses Horses suffering from recurrent airway obstruction (RAO), insect bite hypersensitivity (IBH), or urticaria (URT) will have an increased risk of also being affected by another one of...
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| Veröffentlicht in: | Journal of veterinary internal medicine 2015-01, Vol.29 (1), p.320-326 |
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| description | Background
Multiple hypersensitivities (MHS) have been described in humans, cats, and dogs, but not horses.
Hypotheses
Horses suffering from recurrent airway obstruction (RAO), insect bite hypersensitivity (IBH), or urticaria (URT) will have an increased risk of also being affected by another one of these hypersensitivities. This predisposition for MHS also will be associated with decreased shedding of strongylid eggs in feces and with a single nucleotide polymorphism (SNP BIEC2‐224511), previously shown to be associated with RAO.
Animals
The first population (P1) included 119 randomly sampled horses representative of the Swiss sporthorse population; the replication population (P2) included 210 RAO‐affected Warmblood horses and 264 RAO‐unaffected controls. All horses were Warmbloods, 14 years or older.
Methods
Associations between disease phenotypes (RAO, IBH, URT, MHS) fecal egg counts, the SNP BIEC2‐224511 as well as management and environmental factors were investigated.
Results
In P1, RAO‐affected horses had a 13.1 times higher odds ratio (OR) of also suffering from IBH (P = .004). In P2, the respective OR was 7.4 (P = .002) and IBH‐affected horses also showed a 7.1 times increased OR of concomitantly suffering from URT (P |
| doi_str_mv | 10.1111/jvim.12473 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4858110</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2289578187</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5183-db50780e1c76692024acc43ee3d647f9db6d8f06187c948cc0d799cfda56bb753</originalsourceid><addsrcrecordid>eNp9kd9qFDEUh4Modq3e-AAS8E46NclM_t0ItVh3paUiVi9DJsnULLPJNJnZMm_RRzbr1qIIBg65OB_fOYcfAC8xOsblvV1v_eYYk4bXj8ACy1pWmHH2GCyQkLhirEEH4FnOa4QIpZQ_BQeEEo5o3SzA3cXUj37oHVzOg0vZhexHvy3lMlwF00_Wh2v4xZkpJRdGeOLTrZ7hZZvHNJnRx3BUuOzMCN_78R_NfAR1sPAqjd7o5DX0ARL4XadN28do4TIWGH6Ow9TrnSw_B0863Wf34v4_BFdnH76eLqvzy4-r05PzylAs6sq2FHGBHDacMUkQabQxTe1cbVnDO2lbZkWHGBbcyEYYgyyX0nRWU9a2nNaH4N3eO0ztxllTbku6V0PyG51mFbVXf3eC_6Gu41Y1ggqMURG8vhekeDO5PKp1nFIoOytChKRclNmFerOnTIo5J9c9TMBI7dJTu_TUr_QK_OrPnR7Q33EVAO-BW9-7-T8q9enb6mIv_Qksnqne</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2289578187</pqid></control><display><type>article</type><title>Multiple Hypersensitivities Including Recurrent Airway Obstruction, Insect Bite Hypersensitivity, and Urticaria in 2 Warmblood Horse Populations</title><source>Wiley Online Library Open Access</source><creator>Kehrli, D. ; Jandova, V. ; Fey, K. ; Jahn, P. ; Gerber, V.</creator><creatorcontrib>Kehrli, D. ; Jandova, V. ; Fey, K. ; Jahn, P. ; Gerber, V.</creatorcontrib><description>Background
Multiple hypersensitivities (MHS) have been described in humans, cats, and dogs, but not horses.
Hypotheses
Horses suffering from recurrent airway obstruction (RAO), insect bite hypersensitivity (IBH), or urticaria (URT) will have an increased risk of also being affected by another one of these hypersensitivities. This predisposition for MHS also will be associated with decreased shedding of strongylid eggs in feces and with a single nucleotide polymorphism (SNP BIEC2‐224511), previously shown to be associated with RAO.
Animals
The first population (P1) included 119 randomly sampled horses representative of the Swiss sporthorse population; the replication population (P2) included 210 RAO‐affected Warmblood horses and 264 RAO‐unaffected controls. All horses were Warmbloods, 14 years or older.
Methods
Associations between disease phenotypes (RAO, IBH, URT, MHS) fecal egg counts, the SNP BIEC2‐224511 as well as management and environmental factors were investigated.
Results
In P1, RAO‐affected horses had a 13.1 times higher odds ratio (OR) of also suffering from IBH (P = .004). In P2, the respective OR was 7.4 (P = .002) and IBH‐affected horses also showed a 7.1 times increased OR of concomitantly suffering from URT (P < .001). IBH, URT, and MHS phenotypes were significantly associated with the absence of nematode eggs in the feces.
Conclusions and Clinical Importance
This is the first report of MHS in horses. Specifically, an increased risk for IBH should be expected in RAO‐affected horses.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/jvim.12473</identifier><identifier>PMID: 25270534</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Age ; Airway disease ; Airway management ; Animal populations ; Animals ; Asthma ; Cytokines ; Data Collection ; Dermatitis ; Disease ; Eggs ; Environmental factors ; Environmental management ; Equine ; Europe - epidemiology ; Feces ; Female ; Genetics ; Horse Diseases - epidemiology ; Horse Diseases - immunology ; Horse Owner Assessed Respiratory Signs Index ; Horses ; Hypersensitivity ; Hypersensitivity - epidemiology ; Hypersensitivity - immunology ; Hypersensitivity - veterinary ; Hypotheses ; Immunoglobulins ; Insect bites ; Insect Bites and Stings - epidemiology ; Insect Bites and Stings - immunology ; Insect Bites and Stings - veterinary ; Lung Diseases, Obstructive - epidemiology ; Lung Diseases, Obstructive - veterinary ; Male ; Polymorphism ; Population ; Questionnaires ; Respiratory tract ; Single-nucleotide polymorphism ; Studies ; Urticaria ; Urticaria - epidemiology ; Urticaria - immunology ; Urticaria - veterinary</subject><ispartof>Journal of veterinary internal medicine, 2015-01, Vol.29 (1), p.320-326</ispartof><rights>Copyright © 2014 by the American College of Veterinary Internal Medicine</rights><rights>Copyright © 2014 by the American College of Veterinary Internal Medicine.</rights><rights>2015. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5183-db50780e1c76692024acc43ee3d647f9db6d8f06187c948cc0d799cfda56bb753</citedby><cites>FETCH-LOGICAL-c5183-db50780e1c76692024acc43ee3d647f9db6d8f06187c948cc0d799cfda56bb753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858110/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858110/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjvim.12473$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25270534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kehrli, D.</creatorcontrib><creatorcontrib>Jandova, V.</creatorcontrib><creatorcontrib>Fey, K.</creatorcontrib><creatorcontrib>Jahn, P.</creatorcontrib><creatorcontrib>Gerber, V.</creatorcontrib><title>Multiple Hypersensitivities Including Recurrent Airway Obstruction, Insect Bite Hypersensitivity, and Urticaria in 2 Warmblood Horse Populations</title><title>Journal of veterinary internal medicine</title><addtitle>J Vet Intern Med</addtitle><description>Background
Multiple hypersensitivities (MHS) have been described in humans, cats, and dogs, but not horses.
Hypotheses
Horses suffering from recurrent airway obstruction (RAO), insect bite hypersensitivity (IBH), or urticaria (URT) will have an increased risk of also being affected by another one of these hypersensitivities. This predisposition for MHS also will be associated with decreased shedding of strongylid eggs in feces and with a single nucleotide polymorphism (SNP BIEC2‐224511), previously shown to be associated with RAO.
Animals
The first population (P1) included 119 randomly sampled horses representative of the Swiss sporthorse population; the replication population (P2) included 210 RAO‐affected Warmblood horses and 264 RAO‐unaffected controls. All horses were Warmbloods, 14 years or older.
Methods
Associations between disease phenotypes (RAO, IBH, URT, MHS) fecal egg counts, the SNP BIEC2‐224511 as well as management and environmental factors were investigated.
Results
In P1, RAO‐affected horses had a 13.1 times higher odds ratio (OR) of also suffering from IBH (P = .004). In P2, the respective OR was 7.4 (P = .002) and IBH‐affected horses also showed a 7.1 times increased OR of concomitantly suffering from URT (P < .001). IBH, URT, and MHS phenotypes were significantly associated with the absence of nematode eggs in the feces.
Conclusions and Clinical Importance
This is the first report of MHS in horses. Specifically, an increased risk for IBH should be expected in RAO‐affected horses.</description><subject>Age</subject><subject>Airway disease</subject><subject>Airway management</subject><subject>Animal populations</subject><subject>Animals</subject><subject>Asthma</subject><subject>Cytokines</subject><subject>Data Collection</subject><subject>Dermatitis</subject><subject>Disease</subject><subject>Eggs</subject><subject>Environmental factors</subject><subject>Environmental management</subject><subject>Equine</subject><subject>Europe - epidemiology</subject><subject>Feces</subject><subject>Female</subject><subject>Genetics</subject><subject>Horse Diseases - epidemiology</subject><subject>Horse Diseases - immunology</subject><subject>Horse Owner Assessed Respiratory Signs Index</subject><subject>Horses</subject><subject>Hypersensitivity</subject><subject>Hypersensitivity - epidemiology</subject><subject>Hypersensitivity - immunology</subject><subject>Hypersensitivity - veterinary</subject><subject>Hypotheses</subject><subject>Immunoglobulins</subject><subject>Insect bites</subject><subject>Insect Bites and Stings - epidemiology</subject><subject>Insect Bites and Stings - immunology</subject><subject>Insect Bites and Stings - veterinary</subject><subject>Lung Diseases, Obstructive - epidemiology</subject><subject>Lung Diseases, Obstructive - veterinary</subject><subject>Male</subject><subject>Polymorphism</subject><subject>Population</subject><subject>Questionnaires</subject><subject>Respiratory tract</subject><subject>Single-nucleotide polymorphism</subject><subject>Studies</subject><subject>Urticaria</subject><subject>Urticaria - epidemiology</subject><subject>Urticaria - immunology</subject><subject>Urticaria - veterinary</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kd9qFDEUh4Modq3e-AAS8E46NclM_t0ItVh3paUiVi9DJsnULLPJNJnZMm_RRzbr1qIIBg65OB_fOYcfAC8xOsblvV1v_eYYk4bXj8ACy1pWmHH2GCyQkLhirEEH4FnOa4QIpZQ_BQeEEo5o3SzA3cXUj37oHVzOg0vZhexHvy3lMlwF00_Wh2v4xZkpJRdGeOLTrZ7hZZvHNJnRx3BUuOzMCN_78R_NfAR1sPAqjd7o5DX0ARL4XadN28do4TIWGH6Ow9TrnSw_B0863Wf34v4_BFdnH76eLqvzy4-r05PzylAs6sq2FHGBHDacMUkQabQxTe1cbVnDO2lbZkWHGBbcyEYYgyyX0nRWU9a2nNaH4N3eO0ztxllTbku6V0PyG51mFbVXf3eC_6Gu41Y1ggqMURG8vhekeDO5PKp1nFIoOytChKRclNmFerOnTIo5J9c9TMBI7dJTu_TUr_QK_OrPnR7Q33EVAO-BW9-7-T8q9enb6mIv_Qksnqne</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Kehrli, D.</creator><creator>Jandova, V.</creator><creator>Fey, K.</creator><creator>Jahn, P.</creator><creator>Gerber, V.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>201501</creationdate><title>Multiple Hypersensitivities Including Recurrent Airway Obstruction, Insect Bite Hypersensitivity, and Urticaria in 2 Warmblood Horse Populations</title><author>Kehrli, D. ; Jandova, V. ; Fey, K. ; Jahn, P. ; Gerber, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5183-db50780e1c76692024acc43ee3d647f9db6d8f06187c948cc0d799cfda56bb753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age</topic><topic>Airway disease</topic><topic>Airway management</topic><topic>Animal populations</topic><topic>Animals</topic><topic>Asthma</topic><topic>Cytokines</topic><topic>Data Collection</topic><topic>Dermatitis</topic><topic>Disease</topic><topic>Eggs</topic><topic>Environmental factors</topic><topic>Environmental management</topic><topic>Equine</topic><topic>Europe - epidemiology</topic><topic>Feces</topic><topic>Female</topic><topic>Genetics</topic><topic>Horse Diseases - epidemiology</topic><topic>Horse Diseases - immunology</topic><topic>Horse Owner Assessed Respiratory Signs Index</topic><topic>Horses</topic><topic>Hypersensitivity</topic><topic>Hypersensitivity - epidemiology</topic><topic>Hypersensitivity - immunology</topic><topic>Hypersensitivity - veterinary</topic><topic>Hypotheses</topic><topic>Immunoglobulins</topic><topic>Insect bites</topic><topic>Insect Bites and Stings - epidemiology</topic><topic>Insect Bites and Stings - immunology</topic><topic>Insect Bites and Stings - veterinary</topic><topic>Lung Diseases, Obstructive - epidemiology</topic><topic>Lung Diseases, Obstructive - veterinary</topic><topic>Male</topic><topic>Polymorphism</topic><topic>Population</topic><topic>Questionnaires</topic><topic>Respiratory tract</topic><topic>Single-nucleotide polymorphism</topic><topic>Studies</topic><topic>Urticaria</topic><topic>Urticaria - epidemiology</topic><topic>Urticaria - immunology</topic><topic>Urticaria - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kehrli, D.</creatorcontrib><creatorcontrib>Jandova, V.</creatorcontrib><creatorcontrib>Fey, K.</creatorcontrib><creatorcontrib>Jahn, P.</creatorcontrib><creatorcontrib>Gerber, V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of veterinary internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Kehrli, D.</au><au>Jandova, V.</au><au>Fey, K.</au><au>Jahn, P.</au><au>Gerber, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple Hypersensitivities Including Recurrent Airway Obstruction, Insect Bite Hypersensitivity, and Urticaria in 2 Warmblood Horse Populations</atitle><jtitle>Journal of veterinary internal medicine</jtitle><addtitle>J Vet Intern Med</addtitle><date>2015-01</date><risdate>2015</risdate><volume>29</volume><issue>1</issue><spage>320</spage><epage>326</epage><pages>320-326</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Background
Multiple hypersensitivities (MHS) have been described in humans, cats, and dogs, but not horses.
Hypotheses
Horses suffering from recurrent airway obstruction (RAO), insect bite hypersensitivity (IBH), or urticaria (URT) will have an increased risk of also being affected by another one of these hypersensitivities. This predisposition for MHS also will be associated with decreased shedding of strongylid eggs in feces and with a single nucleotide polymorphism (SNP BIEC2‐224511), previously shown to be associated with RAO.
Animals
The first population (P1) included 119 randomly sampled horses representative of the Swiss sporthorse population; the replication population (P2) included 210 RAO‐affected Warmblood horses and 264 RAO‐unaffected controls. All horses were Warmbloods, 14 years or older.
Methods
Associations between disease phenotypes (RAO, IBH, URT, MHS) fecal egg counts, the SNP BIEC2‐224511 as well as management and environmental factors were investigated.
Results
In P1, RAO‐affected horses had a 13.1 times higher odds ratio (OR) of also suffering from IBH (P = .004). In P2, the respective OR was 7.4 (P = .002) and IBH‐affected horses also showed a 7.1 times increased OR of concomitantly suffering from URT (P < .001). IBH, URT, and MHS phenotypes were significantly associated with the absence of nematode eggs in the feces.
Conclusions and Clinical Importance
This is the first report of MHS in horses. Specifically, an increased risk for IBH should be expected in RAO‐affected horses.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>25270534</pmid><doi>10.1111/jvim.12473</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of veterinary internal medicine, 2015-01, Vol.29 (1), p.320-326 |
| issn | 0891-6640 1939-1676 |
| language | eng |
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| source | Wiley Online Library Open Access |
| subjects | Age Airway disease Airway management Animal populations Animals Asthma Cytokines Data Collection Dermatitis Disease Eggs Environmental factors Environmental management Equine Europe - epidemiology Feces Female Genetics Horse Diseases - epidemiology Horse Diseases - immunology Horse Owner Assessed Respiratory Signs Index Horses Hypersensitivity Hypersensitivity - epidemiology Hypersensitivity - immunology Hypersensitivity - veterinary Hypotheses Immunoglobulins Insect bites Insect Bites and Stings - epidemiology Insect Bites and Stings - immunology Insect Bites and Stings - veterinary Lung Diseases, Obstructive - epidemiology Lung Diseases, Obstructive - veterinary Male Polymorphism Population Questionnaires Respiratory tract Single-nucleotide polymorphism Studies Urticaria Urticaria - epidemiology Urticaria - immunology Urticaria - veterinary |
| title | Multiple Hypersensitivities Including Recurrent Airway Obstruction, Insect Bite Hypersensitivity, and Urticaria in 2 Warmblood Horse Populations |
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