Relationship of Plasma N‐terminal Pro‐brain Natriuretic Peptide Concentrations to Heart Failure Classification and Cause of Respiratory Distress in Dogs Using a 2nd Generation ELISA Assay
Background Cardiac biomarkers provide objective data that augments clinical assessment of heart disease (HD). Hypothesis/Objectives Determine the utility of plasma N‐terminal pro‐brain natriuretic peptide concentration [NT‐proBNP] measured by a 2nd generation canine ELISA assay to discriminate cardi...
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| Veröffentlicht in: | Journal of veterinary internal medicine 2015-01, Vol.29 (1), p.171-179 |
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| creator | Fox, P.R. Oyama, M.A. Hezzell, M.J. Rush, J.E. Nguyenba, T.P. DeFrancesco, T.C. Lehmkuhl, L.B. Kellihan, H.B. Bulmer, B. Gordon, S.G. Cunningham, S.M. MacGregor, J. Stepien, R.L. Lefbom, B. Adin, D. Lamb, K. |
| description | Background
Cardiac biomarkers provide objective data that augments clinical assessment of heart disease (HD).
Hypothesis/Objectives
Determine the utility of plasma N‐terminal pro‐brain natriuretic peptide concentration [NT‐proBNP] measured by a 2nd generation canine ELISA assay to discriminate cardiac from noncardiac respiratory distress and evaluate HD severity.
Animals
Client‐owned dogs (n = 291).
Methods
Multicenter, cross‐sectional, prospective investigation. Medical history, physical examination, echocardiography, and thoracic radiography classified 113 asymptomatic dogs (group 1, n = 39 without HD; group 2, n = 74 with HD), and 178 with respiratory distress (group 3, n = 104 respiratory disease, either with or without concurrent HD; group 4, n = 74 with congestive heart failure [CHF]). HD severity was graded using International Small Animal Cardiac Health Council (ISACHC) and ACVIM Consensus (ACVIM‐HD) schemes without knowledge of [NT‐proBNP] results. Receiver‐operating characteristic curve analysis assessed the capacity of [NT‐proBNP] to discriminate between dogs with cardiac and noncardiac respiratory distress. Multivariate general linear models containing key clinical variables tested associations between [NT‐proBNP] and HD severity.
Results
Plasma [NT‐proBNP] (median; IQR) was higher in CHF dogs (5,110; 2,769–8,466 pmol/L) compared to those with noncardiac respiratory distress (1,287; 672–2,704 pmol/L; P 2,447 pmol/L discriminated CHF from noncardiac respiratory distress (81.1% sensitivity; 73.1% specificity; area under curve, 0.84). A multivariate model comprising left atrial to aortic ratio, heart rate, left ventricular diameter, end‐systole, and ACVIM‐HD scheme most accurately associated average plasma [NT‐proBNP] with HD severity.
Conclusions and Clinical Importance
Plasma [NT‐proBNP] was useful for discriminating CHF from noncardiac respiratory distress. Average plasma [NT‐BNP] increased significantly as a function of HD severity using the ACVIM‐HD classification scheme. |
| doi_str_mv | 10.1111/jvim.12472 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4858067</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2289578365</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4812-39af104017ccef7b6edd374e864f88b396fa3220b8fabf86b37aa4f0e86fa4c63</originalsourceid><addsrcrecordid>eNqFkt9u0zAUhyMEYmVwwwMgS9wgpA7bcRznBqnq_hWVUQ3GrXWSHneukrizk6He7RH2RrwLT4K7jAm4AN9Ylr_zHR_5lyQvGT1gcb1bX9vmgHGR80fJiBVpMWYyl4-TEVUFG0sp6F7yLIQ1pTzLsvxpssezlCql2Cj5fo41dNa14dJuiDNkUUNogJz9uLnt0De2hZosvIvH0oNtyRl03vYeO1uRBW46u0QydW2FbecHEekcOUXwHTkGW0eUTKMzWGOrO4BAuyRT6APu-p1j2NhY6fyWHNrQeQyBxD6HbhXIRbDtigDhseIEWxw6kKP57POETEKA7fPkiYE64Iv7fT-5OD76Mj0dzz-dzKaT-bgSivFxWoBhVFCWVxWavJS4XKa5QCWFUapMC2kg5ZyWykBplCzTHEAYGgEDopLpfvJ-8G76ssHlMG6tN9424LfagdV_3rT2Uq_ctRYqU1TmUfDmXuDdVY-h040NFdY1tOj6oFnOKBeUMvZ_VGZc8ExlIqKv_0LXrvfxz4LmXBVZrlKZRertQFXeheDRPLybUb2LkN5FSN9FKMKvfp_0Af2VmQiwAfhma9z-Q6U_fJ19HKQ_AfH01y8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2289578365</pqid></control><display><type>article</type><title>Relationship of Plasma N‐terminal Pro‐brain Natriuretic Peptide Concentrations to Heart Failure Classification and Cause of Respiratory Distress in Dogs Using a 2nd Generation ELISA Assay</title><source>Wiley Online Library Open Access</source><creator>Fox, P.R. ; Oyama, M.A. ; Hezzell, M.J. ; Rush, J.E. ; Nguyenba, T.P. ; DeFrancesco, T.C. ; Lehmkuhl, L.B. ; Kellihan, H.B. ; Bulmer, B. ; Gordon, S.G. ; Cunningham, S.M. ; MacGregor, J. ; Stepien, R.L. ; Lefbom, B. ; Adin, D. ; Lamb, K.</creator><creatorcontrib>Fox, P.R. ; Oyama, M.A. ; Hezzell, M.J. ; Rush, J.E. ; Nguyenba, T.P. ; DeFrancesco, T.C. ; Lehmkuhl, L.B. ; Kellihan, H.B. ; Bulmer, B. ; Gordon, S.G. ; Cunningham, S.M. ; MacGregor, J. ; Stepien, R.L. ; Lefbom, B. ; Adin, D. ; Lamb, K.</creatorcontrib><description>Background
Cardiac biomarkers provide objective data that augments clinical assessment of heart disease (HD).
Hypothesis/Objectives
Determine the utility of plasma N‐terminal pro‐brain natriuretic peptide concentration [NT‐proBNP] measured by a 2nd generation canine ELISA assay to discriminate cardiac from noncardiac respiratory distress and evaluate HD severity.
Animals
Client‐owned dogs (n = 291).
Methods
Multicenter, cross‐sectional, prospective investigation. Medical history, physical examination, echocardiography, and thoracic radiography classified 113 asymptomatic dogs (group 1, n = 39 without HD; group 2, n = 74 with HD), and 178 with respiratory distress (group 3, n = 104 respiratory disease, either with or without concurrent HD; group 4, n = 74 with congestive heart failure [CHF]). HD severity was graded using International Small Animal Cardiac Health Council (ISACHC) and ACVIM Consensus (ACVIM‐HD) schemes without knowledge of [NT‐proBNP] results. Receiver‐operating characteristic curve analysis assessed the capacity of [NT‐proBNP] to discriminate between dogs with cardiac and noncardiac respiratory distress. Multivariate general linear models containing key clinical variables tested associations between [NT‐proBNP] and HD severity.
Results
Plasma [NT‐proBNP] (median; IQR) was higher in CHF dogs (5,110; 2,769–8,466 pmol/L) compared to those with noncardiac respiratory distress (1,287; 672–2,704 pmol/L; P < .0001). A cut‐off >2,447 pmol/L discriminated CHF from noncardiac respiratory distress (81.1% sensitivity; 73.1% specificity; area under curve, 0.84). A multivariate model comprising left atrial to aortic ratio, heart rate, left ventricular diameter, end‐systole, and ACVIM‐HD scheme most accurately associated average plasma [NT‐proBNP] with HD severity.
Conclusions and Clinical Importance
Plasma [NT‐proBNP] was useful for discriminating CHF from noncardiac respiratory distress. Average plasma [NT‐BNP] increased significantly as a function of HD severity using the ACVIM‐HD classification scheme.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/jvim.12472</identifier><identifier>PMID: 25308881</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Animals ; Aorta ; Biomarkers ; Brain ; Brain natriuretic peptide ; Canine ; Cardiology ; Cardiomyopathy ; Cardiovascular disease ; Cardiovascular diseases ; Classification ; Classification schemes ; clinical examination ; Congestive heart failure ; Coronary artery disease ; Cross-Sectional Studies ; distress ; Dog Diseases - blood ; Dog Diseases - classification ; Dog Diseases - metabolism ; Dogs ; Dyspnea - blood ; Dyspnea - diagnosis ; Dyspnea - veterinary ; Echocardiography ; Edema ; Enzyme-linked immunosorbent assay ; Enzyme-Linked Immunosorbent Assay - methods ; Enzyme-Linked Immunosorbent Assay - veterinary ; Family medical history ; Female ; Heart disease ; Heart failure ; Heart Failure - blood ; Heart Failure - classification ; Heart Failure - veterinary ; Heart rate ; Internal medicine ; Laboratories ; linear models ; Male ; medical history ; multivariate analysis ; Natriuretic Peptide, Brain - blood ; natriuretic peptides ; Peptide Fragments - blood ; Peptides ; Pulmonary hypertension ; Radiography ; Respiratory diseases ; Respiratory distress ; respiratory tract diseases ; Systole ; Thorax ; Variables ; Ventricle</subject><ispartof>Journal of veterinary internal medicine, 2015-01, Vol.29 (1), p.171-179</ispartof><rights>Copyright © 2014 by the American College of Veterinary Internal Medicine</rights><rights>Copyright © 2014 by the American College of Veterinary Internal Medicine.</rights><rights>2015. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4812-39af104017ccef7b6edd374e864f88b396fa3220b8fabf86b37aa4f0e86fa4c63</citedby><cites>FETCH-LOGICAL-c4812-39af104017ccef7b6edd374e864f88b396fa3220b8fabf86b37aa4f0e86fa4c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858067/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858067/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjvim.12472$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25308881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fox, P.R.</creatorcontrib><creatorcontrib>Oyama, M.A.</creatorcontrib><creatorcontrib>Hezzell, M.J.</creatorcontrib><creatorcontrib>Rush, J.E.</creatorcontrib><creatorcontrib>Nguyenba, T.P.</creatorcontrib><creatorcontrib>DeFrancesco, T.C.</creatorcontrib><creatorcontrib>Lehmkuhl, L.B.</creatorcontrib><creatorcontrib>Kellihan, H.B.</creatorcontrib><creatorcontrib>Bulmer, B.</creatorcontrib><creatorcontrib>Gordon, S.G.</creatorcontrib><creatorcontrib>Cunningham, S.M.</creatorcontrib><creatorcontrib>MacGregor, J.</creatorcontrib><creatorcontrib>Stepien, R.L.</creatorcontrib><creatorcontrib>Lefbom, B.</creatorcontrib><creatorcontrib>Adin, D.</creatorcontrib><creatorcontrib>Lamb, K.</creatorcontrib><title>Relationship of Plasma N‐terminal Pro‐brain Natriuretic Peptide Concentrations to Heart Failure Classification and Cause of Respiratory Distress in Dogs Using a 2nd Generation ELISA Assay</title><title>Journal of veterinary internal medicine</title><addtitle>J Vet Intern Med</addtitle><description>Background
Cardiac biomarkers provide objective data that augments clinical assessment of heart disease (HD).
Hypothesis/Objectives
Determine the utility of plasma N‐terminal pro‐brain natriuretic peptide concentration [NT‐proBNP] measured by a 2nd generation canine ELISA assay to discriminate cardiac from noncardiac respiratory distress and evaluate HD severity.
Animals
Client‐owned dogs (n = 291).
Methods
Multicenter, cross‐sectional, prospective investigation. Medical history, physical examination, echocardiography, and thoracic radiography classified 113 asymptomatic dogs (group 1, n = 39 without HD; group 2, n = 74 with HD), and 178 with respiratory distress (group 3, n = 104 respiratory disease, either with or without concurrent HD; group 4, n = 74 with congestive heart failure [CHF]). HD severity was graded using International Small Animal Cardiac Health Council (ISACHC) and ACVIM Consensus (ACVIM‐HD) schemes without knowledge of [NT‐proBNP] results. Receiver‐operating characteristic curve analysis assessed the capacity of [NT‐proBNP] to discriminate between dogs with cardiac and noncardiac respiratory distress. Multivariate general linear models containing key clinical variables tested associations between [NT‐proBNP] and HD severity.
Results
Plasma [NT‐proBNP] (median; IQR) was higher in CHF dogs (5,110; 2,769–8,466 pmol/L) compared to those with noncardiac respiratory distress (1,287; 672–2,704 pmol/L; P < .0001). A cut‐off >2,447 pmol/L discriminated CHF from noncardiac respiratory distress (81.1% sensitivity; 73.1% specificity; area under curve, 0.84). A multivariate model comprising left atrial to aortic ratio, heart rate, left ventricular diameter, end‐systole, and ACVIM‐HD scheme most accurately associated average plasma [NT‐proBNP] with HD severity.
Conclusions and Clinical Importance
Plasma [NT‐proBNP] was useful for discriminating CHF from noncardiac respiratory distress. Average plasma [NT‐BNP] increased significantly as a function of HD severity using the ACVIM‐HD classification scheme.</description><subject>Animals</subject><subject>Aorta</subject><subject>Biomarkers</subject><subject>Brain</subject><subject>Brain natriuretic peptide</subject><subject>Canine</subject><subject>Cardiology</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Classification</subject><subject>Classification schemes</subject><subject>clinical examination</subject><subject>Congestive heart failure</subject><subject>Coronary artery disease</subject><subject>Cross-Sectional Studies</subject><subject>distress</subject><subject>Dog Diseases - blood</subject><subject>Dog Diseases - classification</subject><subject>Dog Diseases - metabolism</subject><subject>Dogs</subject><subject>Dyspnea - blood</subject><subject>Dyspnea - diagnosis</subject><subject>Dyspnea - veterinary</subject><subject>Echocardiography</subject><subject>Edema</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzyme-Linked Immunosorbent Assay - methods</subject><subject>Enzyme-Linked Immunosorbent Assay - veterinary</subject><subject>Family medical history</subject><subject>Female</subject><subject>Heart disease</subject><subject>Heart failure</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - classification</subject><subject>Heart Failure - veterinary</subject><subject>Heart rate</subject><subject>Internal medicine</subject><subject>Laboratories</subject><subject>linear models</subject><subject>Male</subject><subject>medical history</subject><subject>multivariate analysis</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>natriuretic peptides</subject><subject>Peptide Fragments - blood</subject><subject>Peptides</subject><subject>Pulmonary hypertension</subject><subject>Radiography</subject><subject>Respiratory diseases</subject><subject>Respiratory distress</subject><subject>respiratory tract diseases</subject><subject>Systole</subject><subject>Thorax</subject><subject>Variables</subject><subject>Ventricle</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkt9u0zAUhyMEYmVwwwMgS9wgpA7bcRznBqnq_hWVUQ3GrXWSHneukrizk6He7RH2RrwLT4K7jAm4AN9Ylr_zHR_5lyQvGT1gcb1bX9vmgHGR80fJiBVpMWYyl4-TEVUFG0sp6F7yLIQ1pTzLsvxpssezlCql2Cj5fo41dNa14dJuiDNkUUNogJz9uLnt0De2hZosvIvH0oNtyRl03vYeO1uRBW46u0QydW2FbecHEekcOUXwHTkGW0eUTKMzWGOrO4BAuyRT6APu-p1j2NhY6fyWHNrQeQyBxD6HbhXIRbDtigDhseIEWxw6kKP57POETEKA7fPkiYE64Iv7fT-5OD76Mj0dzz-dzKaT-bgSivFxWoBhVFCWVxWavJS4XKa5QCWFUapMC2kg5ZyWykBplCzTHEAYGgEDopLpfvJ-8G76ssHlMG6tN9424LfagdV_3rT2Uq_ctRYqU1TmUfDmXuDdVY-h040NFdY1tOj6oFnOKBeUMvZ_VGZc8ExlIqKv_0LXrvfxz4LmXBVZrlKZRertQFXeheDRPLybUb2LkN5FSN9FKMKvfp_0Af2VmQiwAfhma9z-Q6U_fJ19HKQ_AfH01y8</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Fox, P.R.</creator><creator>Oyama, M.A.</creator><creator>Hezzell, M.J.</creator><creator>Rush, J.E.</creator><creator>Nguyenba, T.P.</creator><creator>DeFrancesco, T.C.</creator><creator>Lehmkuhl, L.B.</creator><creator>Kellihan, H.B.</creator><creator>Bulmer, B.</creator><creator>Gordon, S.G.</creator><creator>Cunningham, S.M.</creator><creator>MacGregor, J.</creator><creator>Stepien, R.L.</creator><creator>Lefbom, B.</creator><creator>Adin, D.</creator><creator>Lamb, K.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>201501</creationdate><title>Relationship of Plasma N‐terminal Pro‐brain Natriuretic Peptide Concentrations to Heart Failure Classification and Cause of Respiratory Distress in Dogs Using a 2nd Generation ELISA Assay</title><author>Fox, P.R. ; Oyama, M.A. ; Hezzell, M.J. ; Rush, J.E. ; Nguyenba, T.P. ; DeFrancesco, T.C. ; Lehmkuhl, L.B. ; Kellihan, H.B. ; Bulmer, B. ; Gordon, S.G. ; Cunningham, S.M. ; MacGregor, J. ; Stepien, R.L. ; Lefbom, B. ; Adin, D. ; Lamb, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4812-39af104017ccef7b6edd374e864f88b396fa3220b8fabf86b37aa4f0e86fa4c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Aorta</topic><topic>Biomarkers</topic><topic>Brain</topic><topic>Brain natriuretic peptide</topic><topic>Canine</topic><topic>Cardiology</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Classification</topic><topic>Classification schemes</topic><topic>clinical examination</topic><topic>Congestive heart failure</topic><topic>Coronary artery disease</topic><topic>Cross-Sectional Studies</topic><topic>distress</topic><topic>Dog Diseases - blood</topic><topic>Dog Diseases - classification</topic><topic>Dog Diseases - metabolism</topic><topic>Dogs</topic><topic>Dyspnea - blood</topic><topic>Dyspnea - diagnosis</topic><topic>Dyspnea - veterinary</topic><topic>Echocardiography</topic><topic>Edema</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzyme-Linked Immunosorbent Assay - methods</topic><topic>Enzyme-Linked Immunosorbent Assay - veterinary</topic><topic>Family medical history</topic><topic>Female</topic><topic>Heart disease</topic><topic>Heart failure</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - classification</topic><topic>Heart Failure - veterinary</topic><topic>Heart rate</topic><topic>Internal medicine</topic><topic>Laboratories</topic><topic>linear models</topic><topic>Male</topic><topic>medical history</topic><topic>multivariate analysis</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>natriuretic peptides</topic><topic>Peptide Fragments - blood</topic><topic>Peptides</topic><topic>Pulmonary hypertension</topic><topic>Radiography</topic><topic>Respiratory diseases</topic><topic>Respiratory distress</topic><topic>respiratory tract diseases</topic><topic>Systole</topic><topic>Thorax</topic><topic>Variables</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fox, P.R.</creatorcontrib><creatorcontrib>Oyama, M.A.</creatorcontrib><creatorcontrib>Hezzell, M.J.</creatorcontrib><creatorcontrib>Rush, J.E.</creatorcontrib><creatorcontrib>Nguyenba, T.P.</creatorcontrib><creatorcontrib>DeFrancesco, T.C.</creatorcontrib><creatorcontrib>Lehmkuhl, L.B.</creatorcontrib><creatorcontrib>Kellihan, H.B.</creatorcontrib><creatorcontrib>Bulmer, B.</creatorcontrib><creatorcontrib>Gordon, S.G.</creatorcontrib><creatorcontrib>Cunningham, S.M.</creatorcontrib><creatorcontrib>MacGregor, J.</creatorcontrib><creatorcontrib>Stepien, R.L.</creatorcontrib><creatorcontrib>Lefbom, B.</creatorcontrib><creatorcontrib>Adin, D.</creatorcontrib><creatorcontrib>Lamb, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of veterinary internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Fox, P.R.</au><au>Oyama, M.A.</au><au>Hezzell, M.J.</au><au>Rush, J.E.</au><au>Nguyenba, T.P.</au><au>DeFrancesco, T.C.</au><au>Lehmkuhl, L.B.</au><au>Kellihan, H.B.</au><au>Bulmer, B.</au><au>Gordon, S.G.</au><au>Cunningham, S.M.</au><au>MacGregor, J.</au><au>Stepien, R.L.</au><au>Lefbom, B.</au><au>Adin, D.</au><au>Lamb, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of Plasma N‐terminal Pro‐brain Natriuretic Peptide Concentrations to Heart Failure Classification and Cause of Respiratory Distress in Dogs Using a 2nd Generation ELISA Assay</atitle><jtitle>Journal of veterinary internal medicine</jtitle><addtitle>J Vet Intern Med</addtitle><date>2015-01</date><risdate>2015</risdate><volume>29</volume><issue>1</issue><spage>171</spage><epage>179</epage><pages>171-179</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Background
Cardiac biomarkers provide objective data that augments clinical assessment of heart disease (HD).
Hypothesis/Objectives
Determine the utility of plasma N‐terminal pro‐brain natriuretic peptide concentration [NT‐proBNP] measured by a 2nd generation canine ELISA assay to discriminate cardiac from noncardiac respiratory distress and evaluate HD severity.
Animals
Client‐owned dogs (n = 291).
Methods
Multicenter, cross‐sectional, prospective investigation. Medical history, physical examination, echocardiography, and thoracic radiography classified 113 asymptomatic dogs (group 1, n = 39 without HD; group 2, n = 74 with HD), and 178 with respiratory distress (group 3, n = 104 respiratory disease, either with or without concurrent HD; group 4, n = 74 with congestive heart failure [CHF]). HD severity was graded using International Small Animal Cardiac Health Council (ISACHC) and ACVIM Consensus (ACVIM‐HD) schemes without knowledge of [NT‐proBNP] results. Receiver‐operating characteristic curve analysis assessed the capacity of [NT‐proBNP] to discriminate between dogs with cardiac and noncardiac respiratory distress. Multivariate general linear models containing key clinical variables tested associations between [NT‐proBNP] and HD severity.
Results
Plasma [NT‐proBNP] (median; IQR) was higher in CHF dogs (5,110; 2,769–8,466 pmol/L) compared to those with noncardiac respiratory distress (1,287; 672–2,704 pmol/L; P < .0001). A cut‐off >2,447 pmol/L discriminated CHF from noncardiac respiratory distress (81.1% sensitivity; 73.1% specificity; area under curve, 0.84). A multivariate model comprising left atrial to aortic ratio, heart rate, left ventricular diameter, end‐systole, and ACVIM‐HD scheme most accurately associated average plasma [NT‐proBNP] with HD severity.
Conclusions and Clinical Importance
Plasma [NT‐proBNP] was useful for discriminating CHF from noncardiac respiratory distress. Average plasma [NT‐BNP] increased significantly as a function of HD severity using the ACVIM‐HD classification scheme.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>25308881</pmid><doi>10.1111/jvim.12472</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of veterinary internal medicine, 2015-01, Vol.29 (1), p.171-179 |
| issn | 0891-6640 1939-1676 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4858067 |
| source | Wiley Online Library Open Access |
| subjects | Animals Aorta Biomarkers Brain Brain natriuretic peptide Canine Cardiology Cardiomyopathy Cardiovascular disease Cardiovascular diseases Classification Classification schemes clinical examination Congestive heart failure Coronary artery disease Cross-Sectional Studies distress Dog Diseases - blood Dog Diseases - classification Dog Diseases - metabolism Dogs Dyspnea - blood Dyspnea - diagnosis Dyspnea - veterinary Echocardiography Edema Enzyme-linked immunosorbent assay Enzyme-Linked Immunosorbent Assay - methods Enzyme-Linked Immunosorbent Assay - veterinary Family medical history Female Heart disease Heart failure Heart Failure - blood Heart Failure - classification Heart Failure - veterinary Heart rate Internal medicine Laboratories linear models Male medical history multivariate analysis Natriuretic Peptide, Brain - blood natriuretic peptides Peptide Fragments - blood Peptides Pulmonary hypertension Radiography Respiratory diseases Respiratory distress respiratory tract diseases Systole Thorax Variables Ventricle |
| title | Relationship of Plasma N‐terminal Pro‐brain Natriuretic Peptide Concentrations to Heart Failure Classification and Cause of Respiratory Distress in Dogs Using a 2nd Generation ELISA Assay |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T13%3A06%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_24P&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationship%20of%20Plasma%20N%E2%80%90terminal%20Pro%E2%80%90brain%20Natriuretic%20Peptide%20Concentrations%20to%20Heart%20Failure%20Classification%20and%20Cause%20of%20Respiratory%20Distress%20in%20Dogs%20Using%20a%202nd%20Generation%20ELISA%20Assay&rft.jtitle=Journal%20of%20veterinary%20internal%20medicine&rft.au=Fox,%20P.R.&rft.date=2015-01&rft.volume=29&rft.issue=1&rft.spage=171&rft.epage=179&rft.pages=171-179&rft.issn=0891-6640&rft.eissn=1939-1676&rft_id=info:doi/10.1111/jvim.12472&rft_dat=%3Cproquest_24P%3E2289578365%3C/proquest_24P%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2289578365&rft_id=info:pmid/25308881&rfr_iscdi=true |