The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers
Background Hypothyroidism and dilated cardiomyopathy (DCM) are both common diseases in Doberman Pinschers. A possible influence of hypothyroidism on the etiology and progression of DCM is controversial. Objectives Evaluation of the role of hypothyroidism in etiology and progression of DCM. Animals A...
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| Veröffentlicht in: | Journal of veterinary internal medicine 2015-01, Vol.29 (1), p.141-149 |
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| creator | Beier, P. Reese, S. Holler, P.J. Simak, J. Tater, G. Wess, G. |
| description | Background
Hypothyroidism and dilated cardiomyopathy (DCM) are both common diseases in Doberman Pinschers. A possible influence of hypothyroidism on the etiology and progression of DCM is controversial.
Objectives
Evaluation of the role of hypothyroidism in etiology and progression of DCM.
Animals
A total of 175 Doberman Pinschers.
Methods
In this longitudinal prospective study, echocardiography and 24‐hour ambulatory ECG recordings were performed in all dogs as screening tests for DCM. Total thyroxine (TT4) and thyroid ultrasonography served as initial screening tests for hypothyroidism and low TT4 values were followed up by a thyroid stimulating hormone (TSH) test or free total thyroxine (fT4)/cTSH measurements. Additionally, a follow‐up study of dogs affected by both DCM and hypothyroidism under optimal treatment for hypothyroidism was conducted.
Results
A total of 107 dogs were healthy, 45 dogs had DCM, 11 hypothyroidism, and 12 dogs had both DCM and hypothyroidism. TT4 values as well as the thyroid volumes were equivalent in the healthy dogs and in those with DCM. Neither ventricular premature complexes nor echocardiographic parameters differed between healthy and hypothyroid dogs. Dogs with DCM had a 2.26‐fold (CI0.95 = 1.1–4.8) higher risk of also being affected by hypothyroidism. Despite optimal thyroid treatment of dogs with hypothyroidism and DCM, there was a progression of the heart disease.
Conclusions and Clinical Importance
This study did not confirm a role of hypothyroidism in the etiology or progression of DCM. Treatment of hypothyroidism did not improve the clinical outcome. |
| doi_str_mv | 10.1111/jvim.12476 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4858054</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1652428348</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4486-627b19e2ae5dd380aa384e9b8204bbf314029cb8fe607d53947f5233784c0ab63</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhi0Eokvhwg9AlrggpBR_x74goW1pi4qoUOFqOclk16vEXuxsUf493m6pgANzmcM882hGL0IvKTmhpd5tbv14Qpmo1SO0oIabiqpaPUYLog2tlBLkCD3LeUMIk1LWT9ERk5woo_gCbW7WgL_GAXDs8cW8jdN6TtF3Po_YBzyV6dnk4xBXM3ahw9cprhLk7GPYb5z6wU3Q4aVLnY_jHLeuCPabp7GBNLqAr33I7RpSfo6e9G7I8OK-H6NvH89ulhfV1Zfzy-WHq6oVQqtKsbqhBpgD2XVcE-e4FmAazYhomp5TQZhpG92DInUnuRF1LxnntRYtcY3ix-j9wbvdNSN0LYQpucFukx9dmm103v49CX5tV_HWCi01kaII3twLUvyxgzzZ0ecWhsEFiLtsqZJMMM2FLujrf9BN3KVQ3rOMaSNrJRQr1NsD1aaYc4L-4RhK7D5Cu4_Q3kVY4Fd_nv-A_s6sAPQA_PQDzP9R2U_fLz8fpL8Az3Wn8w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2289576462</pqid></control><display><type>article</type><title>The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers</title><source>Wiley Online Library Open Access</source><creator>Beier, P. ; Reese, S. ; Holler, P.J. ; Simak, J. ; Tater, G. ; Wess, G.</creator><creatorcontrib>Beier, P. ; Reese, S. ; Holler, P.J. ; Simak, J. ; Tater, G. ; Wess, G.</creatorcontrib><description>Background
Hypothyroidism and dilated cardiomyopathy (DCM) are both common diseases in Doberman Pinschers. A possible influence of hypothyroidism on the etiology and progression of DCM is controversial.
Objectives
Evaluation of the role of hypothyroidism in etiology and progression of DCM.
Animals
A total of 175 Doberman Pinschers.
Methods
In this longitudinal prospective study, echocardiography and 24‐hour ambulatory ECG recordings were performed in all dogs as screening tests for DCM. Total thyroxine (TT4) and thyroid ultrasonography served as initial screening tests for hypothyroidism and low TT4 values were followed up by a thyroid stimulating hormone (TSH) test or free total thyroxine (fT4)/cTSH measurements. Additionally, a follow‐up study of dogs affected by both DCM and hypothyroidism under optimal treatment for hypothyroidism was conducted.
Results
A total of 107 dogs were healthy, 45 dogs had DCM, 11 hypothyroidism, and 12 dogs had both DCM and hypothyroidism. TT4 values as well as the thyroid volumes were equivalent in the healthy dogs and in those with DCM. Neither ventricular premature complexes nor echocardiographic parameters differed between healthy and hypothyroid dogs. Dogs with DCM had a 2.26‐fold (CI0.95 = 1.1–4.8) higher risk of also being affected by hypothyroidism. Despite optimal thyroid treatment of dogs with hypothyroidism and DCM, there was a progression of the heart disease.
Conclusions and Clinical Importance
This study did not confirm a role of hypothyroidism in the etiology or progression of DCM. Treatment of hypothyroidism did not improve the clinical outcome.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/jvim.12476</identifier><identifier>PMID: 25306963</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Animals ; Cardiac arrhythmia ; Cardiomyopathy ; Cardiomyopathy, Dilated - complications ; Cardiomyopathy, Dilated - veterinary ; Cardiovascular diseases ; Congenital diseases ; Coronary artery disease ; Dilated cardiomyopathy ; Disease ; Dog Diseases - etiology ; Dogs ; Echocardiography ; Echocardiography - veterinary ; EKG ; Electrocardiography, Ambulatory - veterinary ; Etiology ; Euthyroid sick syndrome ; Heart diseases ; Hypothyroidism ; Hypothyroidism - complications ; Hypothyroidism - veterinary ; Metabolic disorders ; Studies ; Thyroid ; Thyroid gland ; Thyroid sonography ; Thyroid-stimulating hormone ; Thyroxine ; Ultrasonic imaging ; Ventricle</subject><ispartof>Journal of veterinary internal medicine, 2015-01, Vol.29 (1), p.141-149</ispartof><rights>Copyright © 2014 by the American College of Veterinary Internal Medicine</rights><rights>Copyright © 2014 by the American College of Veterinary Internal Medicine.</rights><rights>2015. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4486-627b19e2ae5dd380aa384e9b8204bbf314029cb8fe607d53947f5233784c0ab63</citedby><cites>FETCH-LOGICAL-c4486-627b19e2ae5dd380aa384e9b8204bbf314029cb8fe607d53947f5233784c0ab63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858054/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858054/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjvim.12476$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25306963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beier, P.</creatorcontrib><creatorcontrib>Reese, S.</creatorcontrib><creatorcontrib>Holler, P.J.</creatorcontrib><creatorcontrib>Simak, J.</creatorcontrib><creatorcontrib>Tater, G.</creatorcontrib><creatorcontrib>Wess, G.</creatorcontrib><title>The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers</title><title>Journal of veterinary internal medicine</title><addtitle>J Vet Intern Med</addtitle><description>Background
Hypothyroidism and dilated cardiomyopathy (DCM) are both common diseases in Doberman Pinschers. A possible influence of hypothyroidism on the etiology and progression of DCM is controversial.
Objectives
Evaluation of the role of hypothyroidism in etiology and progression of DCM.
Animals
A total of 175 Doberman Pinschers.
Methods
In this longitudinal prospective study, echocardiography and 24‐hour ambulatory ECG recordings were performed in all dogs as screening tests for DCM. Total thyroxine (TT4) and thyroid ultrasonography served as initial screening tests for hypothyroidism and low TT4 values were followed up by a thyroid stimulating hormone (TSH) test or free total thyroxine (fT4)/cTSH measurements. Additionally, a follow‐up study of dogs affected by both DCM and hypothyroidism under optimal treatment for hypothyroidism was conducted.
Results
A total of 107 dogs were healthy, 45 dogs had DCM, 11 hypothyroidism, and 12 dogs had both DCM and hypothyroidism. TT4 values as well as the thyroid volumes were equivalent in the healthy dogs and in those with DCM. Neither ventricular premature complexes nor echocardiographic parameters differed between healthy and hypothyroid dogs. Dogs with DCM had a 2.26‐fold (CI0.95 = 1.1–4.8) higher risk of also being affected by hypothyroidism. Despite optimal thyroid treatment of dogs with hypothyroidism and DCM, there was a progression of the heart disease.
Conclusions and Clinical Importance
This study did not confirm a role of hypothyroidism in the etiology or progression of DCM. Treatment of hypothyroidism did not improve the clinical outcome.</description><subject>Animals</subject><subject>Cardiac arrhythmia</subject><subject>Cardiomyopathy</subject><subject>Cardiomyopathy, Dilated - complications</subject><subject>Cardiomyopathy, Dilated - veterinary</subject><subject>Cardiovascular diseases</subject><subject>Congenital diseases</subject><subject>Coronary artery disease</subject><subject>Dilated cardiomyopathy</subject><subject>Disease</subject><subject>Dog Diseases - etiology</subject><subject>Dogs</subject><subject>Echocardiography</subject><subject>Echocardiography - veterinary</subject><subject>EKG</subject><subject>Electrocardiography, Ambulatory - veterinary</subject><subject>Etiology</subject><subject>Euthyroid sick syndrome</subject><subject>Heart diseases</subject><subject>Hypothyroidism</subject><subject>Hypothyroidism - complications</subject><subject>Hypothyroidism - veterinary</subject><subject>Metabolic disorders</subject><subject>Studies</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid sonography</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyroxine</subject><subject>Ultrasonic imaging</subject><subject>Ventricle</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kU1v1DAQhi0Eokvhwg9AlrggpBR_x74goW1pi4qoUOFqOclk16vEXuxsUf493m6pgANzmcM882hGL0IvKTmhpd5tbv14Qpmo1SO0oIabiqpaPUYLog2tlBLkCD3LeUMIk1LWT9ERk5woo_gCbW7WgL_GAXDs8cW8jdN6TtF3Po_YBzyV6dnk4xBXM3ahw9cprhLk7GPYb5z6wU3Q4aVLnY_jHLeuCPabp7GBNLqAr33I7RpSfo6e9G7I8OK-H6NvH89ulhfV1Zfzy-WHq6oVQqtKsbqhBpgD2XVcE-e4FmAazYhomp5TQZhpG92DInUnuRF1LxnntRYtcY3ix-j9wbvdNSN0LYQpucFukx9dmm103v49CX5tV_HWCi01kaII3twLUvyxgzzZ0ecWhsEFiLtsqZJMMM2FLujrf9BN3KVQ3rOMaSNrJRQr1NsD1aaYc4L-4RhK7D5Cu4_Q3kVY4Fd_nv-A_s6sAPQA_PQDzP9R2U_fLz8fpL8Az3Wn8w</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Beier, P.</creator><creator>Reese, S.</creator><creator>Holler, P.J.</creator><creator>Simak, J.</creator><creator>Tater, G.</creator><creator>Wess, G.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201501</creationdate><title>The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers</title><author>Beier, P. ; Reese, S. ; Holler, P.J. ; Simak, J. ; Tater, G. ; Wess, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4486-627b19e2ae5dd380aa384e9b8204bbf314029cb8fe607d53947f5233784c0ab63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Cardiac arrhythmia</topic><topic>Cardiomyopathy</topic><topic>Cardiomyopathy, Dilated - complications</topic><topic>Cardiomyopathy, Dilated - veterinary</topic><topic>Cardiovascular diseases</topic><topic>Congenital diseases</topic><topic>Coronary artery disease</topic><topic>Dilated cardiomyopathy</topic><topic>Disease</topic><topic>Dog Diseases - etiology</topic><topic>Dogs</topic><topic>Echocardiography</topic><topic>Echocardiography - veterinary</topic><topic>EKG</topic><topic>Electrocardiography, Ambulatory - veterinary</topic><topic>Etiology</topic><topic>Euthyroid sick syndrome</topic><topic>Heart diseases</topic><topic>Hypothyroidism</topic><topic>Hypothyroidism - complications</topic><topic>Hypothyroidism - veterinary</topic><topic>Metabolic disorders</topic><topic>Studies</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid sonography</topic><topic>Thyroid-stimulating hormone</topic><topic>Thyroxine</topic><topic>Ultrasonic imaging</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beier, P.</creatorcontrib><creatorcontrib>Reese, S.</creatorcontrib><creatorcontrib>Holler, P.J.</creatorcontrib><creatorcontrib>Simak, J.</creatorcontrib><creatorcontrib>Tater, G.</creatorcontrib><creatorcontrib>Wess, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of veterinary internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Beier, P.</au><au>Reese, S.</au><au>Holler, P.J.</au><au>Simak, J.</au><au>Tater, G.</au><au>Wess, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers</atitle><jtitle>Journal of veterinary internal medicine</jtitle><addtitle>J Vet Intern Med</addtitle><date>2015-01</date><risdate>2015</risdate><volume>29</volume><issue>1</issue><spage>141</spage><epage>149</epage><pages>141-149</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Background
Hypothyroidism and dilated cardiomyopathy (DCM) are both common diseases in Doberman Pinschers. A possible influence of hypothyroidism on the etiology and progression of DCM is controversial.
Objectives
Evaluation of the role of hypothyroidism in etiology and progression of DCM.
Animals
A total of 175 Doberman Pinschers.
Methods
In this longitudinal prospective study, echocardiography and 24‐hour ambulatory ECG recordings were performed in all dogs as screening tests for DCM. Total thyroxine (TT4) and thyroid ultrasonography served as initial screening tests for hypothyroidism and low TT4 values were followed up by a thyroid stimulating hormone (TSH) test or free total thyroxine (fT4)/cTSH measurements. Additionally, a follow‐up study of dogs affected by both DCM and hypothyroidism under optimal treatment for hypothyroidism was conducted.
Results
A total of 107 dogs were healthy, 45 dogs had DCM, 11 hypothyroidism, and 12 dogs had both DCM and hypothyroidism. TT4 values as well as the thyroid volumes were equivalent in the healthy dogs and in those with DCM. Neither ventricular premature complexes nor echocardiographic parameters differed between healthy and hypothyroid dogs. Dogs with DCM had a 2.26‐fold (CI0.95 = 1.1–4.8) higher risk of also being affected by hypothyroidism. Despite optimal thyroid treatment of dogs with hypothyroidism and DCM, there was a progression of the heart disease.
Conclusions and Clinical Importance
This study did not confirm a role of hypothyroidism in the etiology or progression of DCM. Treatment of hypothyroidism did not improve the clinical outcome.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>25306963</pmid><doi>10.1111/jvim.12476</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cardiac arrhythmia Cardiomyopathy Cardiomyopathy, Dilated - complications Cardiomyopathy, Dilated - veterinary Cardiovascular diseases Congenital diseases Coronary artery disease Dilated cardiomyopathy Disease Dog Diseases - etiology Dogs Echocardiography Echocardiography - veterinary EKG Electrocardiography, Ambulatory - veterinary Etiology Euthyroid sick syndrome Heart diseases Hypothyroidism Hypothyroidism - complications Hypothyroidism - veterinary Metabolic disorders Studies Thyroid Thyroid gland Thyroid sonography Thyroid-stimulating hormone Thyroxine Ultrasonic imaging Ventricle |
| title | The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers |
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