Spatial-Temporal Co-Circulation of Dengue Virus 1, 2, 3, and 4 Associated with Coinfection Cases in a Hyperendemic Area of Brazil: A 4-Week Survey
Dengue is currently regarded as a major public health problem worldwide. In a hyperendemic region during an outbreak, we detected the co-circulation of all Dengue virus (DENV) serotypes including two different genotypes of DENV-3 and DENV-4, and concurrent infections with up to three serotypes were...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2016-05, Vol.94 (5), p.1080-1084 |
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| creator | Andrade, Elisa H P Figueiredo, Leandra B Vilela, Ana P P Rosa, Júlio C C Oliveira, Jaquelline G Zibaoui, Hassan M Araújo, Valdelaine E M Miranda, Daniela P J Ferreira, Paulo C P Abrahão, Jonatas S Kroon, Erna G |
| description | Dengue is currently regarded as a major public health problem worldwide. In a hyperendemic region during an outbreak, we detected the co-circulation of all Dengue virus (DENV) serotypes including two different genotypes of DENV-3 and DENV-4, and concurrent infections with up to three serotypes were identified in symptomatic patients. A total of 49 acute phase plasma samples from patients clinically suspected of dengue were collected during the 4 weeks of May 2013. DENV-1-4 was detected by reverse transcriptase semi-nested polymerase chain reaction in 33 samples (67.3%), of which 26 DNA fragments were sequenced. Twenty samples (76.9%) were identified with a single DENV serotype and six (23.1%) with more than one serotype. DENV-3 was the predominant serotype of the outbreak. On the basis of phylogenetic analyses, DENV-1 isolates belong to genotype V, DENV-2 to American-Asian genotype, DENV-3 to genotypes I and III, and DENV-4 to genotypes I and II. |
| doi_str_mv | 10.4269/ajtmh.15-0892 |
| format | Article |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Brazil - epidemiology Coinfection Dengue - epidemiology Dengue - virology Dengue Virus - classification Dengue Virus - genetics Dengue virus type 1 Endemic Diseases Humans Time Factors |
| title | Spatial-Temporal Co-Circulation of Dengue Virus 1, 2, 3, and 4 Associated with Coinfection Cases in a Hyperendemic Area of Brazil: A 4-Week Survey |
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