Helicobacter pylori isolated from Iranian drinking water: vacA, cagA, iceA, oipA and babA2 genotype status and antimicrobial resistance properties
Despite the clinical importance of Helicobacter pylori in human gastric disorders, its exact route of transmission is still uncertain. Based on the contentious hypothesis and findings of previous investigations, water may play an important role in the transmission of H. pylori to humans. This study...
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| Veröffentlicht in: | FEBS open bio 2016-05, Vol.6 (5), p.433-441 |
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| description | Despite the clinical importance of Helicobacter pylori in human gastric disorders, its exact route of transmission is still uncertain. Based on the contentious hypothesis and findings of previous investigations, water may play an important role in the transmission of H. pylori to humans. This study was carried out to investigate the vacA, cagA, oipA, iceA and babA2 genotype status and antimicrobial resistance properties of H. pylori strains isolated from the drinking water samples of four major provinces in Iran. A total of 400 drinking water samples were cultured and tested. H. pylori‐positive strains were analyzed for the presence of various genotypes and antimicrobial resistance. Twelve of 400 (3%) water samples were positive for H. pylori. Samples from Isfahan province had the highest, while those from Shiraz had the lowest prevalence of H. pylori. The seasonal distribution was also determined, with the highest prevalence of bacteria in the summer season (7.36%). H. pylori strains harbored the highest levels of resistance against ampicillin (100%), erythromycin (75%), clarithromycin (75%), and trimethoprim (58.3%). The most commonly detected genotypes were vacAs1a (83.3%), vacAm1a (66.6%), vacAs2 (50%) and cagA (50%). The presence of similar genotypes in the H. pylori strains of drinking water and those of human clinical samples suggest that contaminated water maybe the sources of bacteria. Spiramycin and furazolidone are suggested for the treatment of cases of H. pylori infection.
Water may play an important role in the transmission of Helicobacter pylori to humans. From drinking water samples collected in four provinces in Iran, 3% tested positive for H. pylori. These strains harbored resistance against antibiotics including ampicillin, erythromycin, clarithromycin, and trimethoprim. The most commonly detected genotypes were vacAs1a, vacAm1a, vacAs2 and cagA. The presence of similar genotypes to those found in clinical samples suggests that contaminated water might be the source of bacteria. |
| doi_str_mv | 10.1002/2211-5463.12054 |
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Water may play an important role in the transmission of Helicobacter pylori to humans. From drinking water samples collected in four provinces in Iran, 3% tested positive for H. pylori. These strains harbored resistance against antibiotics including ampicillin, erythromycin, clarithromycin, and trimethoprim. The most commonly detected genotypes were vacAs1a, vacAm1a, vacAs2 and cagA. The presence of similar genotypes to those found in clinical samples suggests that contaminated water might be the source of bacteria.</description><identifier>ISSN: 2211-5463</identifier><identifier>EISSN: 2211-5463</identifier><identifier>DOI: 10.1002/2211-5463.12054</identifier><identifier>PMID: 27419049</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Ampicillin ; antibiotic resistance properties ; Antibiotics ; Antigens ; Antimicrobial agents ; Antimicrobial resistance ; Bacteria ; Blood groups ; Clarithromycin ; Clinical outcomes ; Disease ; Drinking water ; Drug resistance ; Epidemiology ; Erythromycin ; Furazolidone ; Gene amplification ; Genotypes ; genotyping ; Helicobacter pylori ; Infections ; Iran ; Laboratories ; Seasonal distribution ; Spiramycin ; Strains (organisms) ; Trimethoprim ; Ulcers</subject><ispartof>FEBS open bio, 2016-05, Vol.6 (5), p.433-441</ispartof><rights>2016 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.</rights><rights>2016. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5294-de9b822c1a7bcdccba1b04f52a6df70dcddd249731959106515cb5d8b1f950ef3</citedby><cites>FETCH-LOGICAL-c5294-de9b822c1a7bcdccba1b04f52a6df70dcddd249731959106515cb5d8b1f950ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856422/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856422/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27419049$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ranjbar, Reza</creatorcontrib><creatorcontrib>Khamesipour, Faham</creatorcontrib><creatorcontrib>Jonaidi‐Jafari, Nematollah</creatorcontrib><creatorcontrib>Rahimi, Ebrahim</creatorcontrib><title>Helicobacter pylori isolated from Iranian drinking water: vacA, cagA, iceA, oipA and babA2 genotype status and antimicrobial resistance properties</title><title>FEBS open bio</title><addtitle>FEBS Open Bio</addtitle><description>Despite the clinical importance of Helicobacter pylori in human gastric disorders, its exact route of transmission is still uncertain. Based on the contentious hypothesis and findings of previous investigations, water may play an important role in the transmission of H. pylori to humans. This study was carried out to investigate the vacA, cagA, oipA, iceA and babA2 genotype status and antimicrobial resistance properties of H. pylori strains isolated from the drinking water samples of four major provinces in Iran. A total of 400 drinking water samples were cultured and tested. H. pylori‐positive strains were analyzed for the presence of various genotypes and antimicrobial resistance. Twelve of 400 (3%) water samples were positive for H. pylori. Samples from Isfahan province had the highest, while those from Shiraz had the lowest prevalence of H. pylori. The seasonal distribution was also determined, with the highest prevalence of bacteria in the summer season (7.36%). H. pylori strains harbored the highest levels of resistance against ampicillin (100%), erythromycin (75%), clarithromycin (75%), and trimethoprim (58.3%). The most commonly detected genotypes were vacAs1a (83.3%), vacAm1a (66.6%), vacAs2 (50%) and cagA (50%). The presence of similar genotypes in the H. pylori strains of drinking water and those of human clinical samples suggest that contaminated water maybe the sources of bacteria. Spiramycin and furazolidone are suggested for the treatment of cases of H. pylori infection.
Water may play an important role in the transmission of Helicobacter pylori to humans. From drinking water samples collected in four provinces in Iran, 3% tested positive for H. pylori. These strains harbored resistance against antibiotics including ampicillin, erythromycin, clarithromycin, and trimethoprim. The most commonly detected genotypes were vacAs1a, vacAm1a, vacAs2 and cagA. 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Khamesipour, Faham ; Jonaidi‐Jafari, Nematollah ; Rahimi, Ebrahim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5294-de9b822c1a7bcdccba1b04f52a6df70dcddd249731959106515cb5d8b1f950ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Ampicillin</topic><topic>antibiotic resistance properties</topic><topic>Antibiotics</topic><topic>Antigens</topic><topic>Antimicrobial agents</topic><topic>Antimicrobial resistance</topic><topic>Bacteria</topic><topic>Blood groups</topic><topic>Clarithromycin</topic><topic>Clinical outcomes</topic><topic>Disease</topic><topic>Drinking water</topic><topic>Drug resistance</topic><topic>Epidemiology</topic><topic>Erythromycin</topic><topic>Furazolidone</topic><topic>Gene amplification</topic><topic>Genotypes</topic><topic>genotyping</topic><topic>Helicobacter pylori</topic><topic>Infections</topic><topic>Iran</topic><topic>Laboratories</topic><topic>Seasonal distribution</topic><topic>Spiramycin</topic><topic>Strains (organisms)</topic><topic>Trimethoprim</topic><topic>Ulcers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ranjbar, Reza</creatorcontrib><creatorcontrib>Khamesipour, Faham</creatorcontrib><creatorcontrib>Jonaidi‐Jafari, Nematollah</creatorcontrib><creatorcontrib>Rahimi, Ebrahim</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>FEBS open bio</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ranjbar, Reza</au><au>Khamesipour, Faham</au><au>Jonaidi‐Jafari, Nematollah</au><au>Rahimi, Ebrahim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Helicobacter pylori isolated from Iranian drinking water: vacA, cagA, iceA, oipA and babA2 genotype status and antimicrobial resistance properties</atitle><jtitle>FEBS open bio</jtitle><addtitle>FEBS Open Bio</addtitle><date>2016-05</date><risdate>2016</risdate><volume>6</volume><issue>5</issue><spage>433</spage><epage>441</epage><pages>433-441</pages><issn>2211-5463</issn><eissn>2211-5463</eissn><abstract>Despite the clinical importance of Helicobacter pylori in human gastric disorders, its exact route of transmission is still uncertain. Based on the contentious hypothesis and findings of previous investigations, water may play an important role in the transmission of H. pylori to humans. This study was carried out to investigate the vacA, cagA, oipA, iceA and babA2 genotype status and antimicrobial resistance properties of H. pylori strains isolated from the drinking water samples of four major provinces in Iran. A total of 400 drinking water samples were cultured and tested. H. pylori‐positive strains were analyzed for the presence of various genotypes and antimicrobial resistance. Twelve of 400 (3%) water samples were positive for H. pylori. Samples from Isfahan province had the highest, while those from Shiraz had the lowest prevalence of H. pylori. The seasonal distribution was also determined, with the highest prevalence of bacteria in the summer season (7.36%). H. pylori strains harbored the highest levels of resistance against ampicillin (100%), erythromycin (75%), clarithromycin (75%), and trimethoprim (58.3%). The most commonly detected genotypes were vacAs1a (83.3%), vacAm1a (66.6%), vacAs2 (50%) and cagA (50%). The presence of similar genotypes in the H. pylori strains of drinking water and those of human clinical samples suggest that contaminated water maybe the sources of bacteria. Spiramycin and furazolidone are suggested for the treatment of cases of H. pylori infection.
Water may play an important role in the transmission of Helicobacter pylori to humans. From drinking water samples collected in four provinces in Iran, 3% tested positive for H. pylori. These strains harbored resistance against antibiotics including ampicillin, erythromycin, clarithromycin, and trimethoprim. The most commonly detected genotypes were vacAs1a, vacAm1a, vacAs2 and cagA. The presence of similar genotypes to those found in clinical samples suggests that contaminated water might be the source of bacteria.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>27419049</pmid><doi>10.1002/2211-5463.12054</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Ampicillin antibiotic resistance properties Antibiotics Antigens Antimicrobial agents Antimicrobial resistance Bacteria Blood groups Clarithromycin Clinical outcomes Disease Drinking water Drug resistance Epidemiology Erythromycin Furazolidone Gene amplification Genotypes genotyping Helicobacter pylori Infections Iran Laboratories Seasonal distribution Spiramycin Strains (organisms) Trimethoprim Ulcers |
| title | Helicobacter pylori isolated from Iranian drinking water: vacA, cagA, iceA, oipA and babA2 genotype status and antimicrobial resistance properties |
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