Liposomal Amphotericin B (AmBisome®): A Review of the Pharmacokinetics, Pharmacodynamics, Clinical Experience and Future Directions

Liposomal amphotericin B (AmBisome ® ; LAmB) is a unique lipid formulation of amphotericin B. LAmB is a standard of care for a wide range of medically important opportunistic fungal pathogens. LAmB has a significantly improved toxicity profile compared with conventional amphotericin B deoxycholate (...

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Veröffentlicht in:	Drugs (New York, N.Y.) N.Y.), 2016-03, Vol.76 (4), p.485-500
Hauptverfasser:	Stone, Neil R. H., Bicanic, Tihana, Salim, Rahuman, Hope, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B - pharmacokinetics Amphotericin B - pharmacology Animals Antifungal agents Body temperature Cell death Chemistry, Pharmaceutical - methods Chromatography Clinical Trials as Topic Deoxycholic Acid - pharmacokinetics Deoxycholic Acid - pharmacology Drug Combinations Drug dosages Half-Life Humans Internal Medicine Lipids Medicine Medicine & Public Health Pathogens Pharmacodynamics Pharmacokinetics Pharmacology/Toxicology Pharmacotherapy Phase transitions Review Article Tissue Distribution Toxicity
Online-Zugang:	Volltext
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