A Computational Study of Nasal Spray Deposition Pattern in Four Ethnic Groups
Very little is known about the role of nasal morphology due to ethnic variation on particle deposition pattern in the sinonasal cavity. This preliminary study utilizes computational fluid dynamics (CFD) modeling to investigate sinonasal airway morphology and deposition patterns of intranasal sprayed...
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| Veröffentlicht in: | Journal of aerosol medicine 2016-04, Vol.29 (2), p.153-166 |
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| creator | Keeler, Jarrod A Patki, Aniruddha Woodard, Charles R Frank-Ito, Dennis O |
| description | Very little is known about the role of nasal morphology due to ethnic variation on particle deposition pattern in the sinonasal cavity. This preliminary study utilizes computational fluid dynamics (CFD) modeling to investigate sinonasal airway morphology and deposition patterns of intranasal sprayed particles in the nose and sinuses of individuals from four different ethnic groups: African American (Black); Asian; Caucasian; and Latin American.
Sixteen subjects (four from each ethnic group) with "normal" sinus protocol computed tomography (CT) were selected for CFD analysis. Three-dimensional reconstruction of each subject's sinonasal cavity was created from their personal CT images. CFD simulations were carried out in ANSYS Fluent(™) in two phases: airflow phase was done by numerically solving the Navier-Stokes equations for steady state laminar inhalation; and particle dispersed phase was solved by tracking injected (sprayed) particles through the calculated airflow field. A total of 10,000 particle streams were released from each nostril, 1000 particles per diameter ranging from 5 μm to 50 μm, with size increments of 5 μm.
As reported in the literature, Caucasians (5.31 ± 0.42 cm(-1)) and Latin Americans (5.16 ± 0.40cm(-1)) had the highest surface area to volume ratio, while African Americans had highest nasal index (95.91 ± 2.22). Nasal resistance (NR) was highest among Caucasians (0.046 ± 0.008 Pa.s/mL) and Asians (0.042 ± 0.016Pa.s/mL). Asians and African Americans had the most regions with particle deposition for small (5 μm-15 μm) and large (20 μm-50 μm) particle sizes, respectively. Asians and Latin Americans individuals had the most consistent regional particle deposition pattern in the main nasal cavities within their respective ethnic groups.
Preliminary results from these ethnic groups investigated showed that Caucasians and Latin Americans had the least patent nasal cavity. Furthermore, Caucasians and African Americans had the lowest inter-subject consistency in regional particle deposition pattern; this may be due to greater inter-subject variability in their respective nasal vestibule morphology. |
| doi_str_mv | 10.1089/jamp.2014.1205 |
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Sixteen subjects (four from each ethnic group) with "normal" sinus protocol computed tomography (CT) were selected for CFD analysis. Three-dimensional reconstruction of each subject's sinonasal cavity was created from their personal CT images. CFD simulations were carried out in ANSYS Fluent(™) in two phases: airflow phase was done by numerically solving the Navier-Stokes equations for steady state laminar inhalation; and particle dispersed phase was solved by tracking injected (sprayed) particles through the calculated airflow field. A total of 10,000 particle streams were released from each nostril, 1000 particles per diameter ranging from 5 μm to 50 μm, with size increments of 5 μm.
As reported in the literature, Caucasians (5.31 ± 0.42 cm(-1)) and Latin Americans (5.16 ± 0.40cm(-1)) had the highest surface area to volume ratio, while African Americans had highest nasal index (95.91 ± 2.22). Nasal resistance (NR) was highest among Caucasians (0.046 ± 0.008 Pa.s/mL) and Asians (0.042 ± 0.016Pa.s/mL). Asians and African Americans had the most regions with particle deposition for small (5 μm-15 μm) and large (20 μm-50 μm) particle sizes, respectively. Asians and Latin Americans individuals had the most consistent regional particle deposition pattern in the main nasal cavities within their respective ethnic groups.
Preliminary results from these ethnic groups investigated showed that Caucasians and Latin Americans had the least patent nasal cavity. Furthermore, Caucasians and African Americans had the lowest inter-subject consistency in regional particle deposition pattern; this may be due to greater inter-subject variability in their respective nasal vestibule morphology.</description><identifier>ISSN: 1941-2711</identifier><identifier>EISSN: 1941-2703</identifier><identifier>DOI: 10.1089/jamp.2014.1205</identifier><identifier>PMID: 26270330</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Administration, Inhalation ; Aerosols ; Airway Resistance ; Asian ; Black or African American ; Computer Simulation ; Ethnicity ; Female ; Hispanic or Latino ; Humans ; Hydrodynamics ; Imaging, Three-Dimensional ; Male ; Models, Anatomic ; Nasal Cavity - anatomy & histology ; Nasal Cavity - diagnostic imaging ; Nasal Cavity - physiology ; Numerical Analysis, Computer-Assisted ; Original Research ; Paranasal Sinuses - anatomy & histology ; Paranasal Sinuses - diagnostic imaging ; Paranasal Sinuses - physiology ; Particle Size ; Pharmaceutical Preparations - administration & dosage ; Radiographic Image Interpretation, Computer-Assisted ; Respiration ; Tomography, Spiral Computed ; White People</subject><ispartof>Journal of aerosol medicine, 2016-04, Vol.29 (2), p.153-166</ispartof><rights>(©) Copyright 2016, Mary Ann Liebert, Inc.</rights><rights>Copyright 2016, Mary Ann Liebert, Inc. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-8932c042ae4a7cf619e24a5859ab1143de25268f697d2c784d3b0c61d248b1b03</citedby><cites>FETCH-LOGICAL-c517t-8932c042ae4a7cf619e24a5859ab1143de25268f697d2c784d3b0c61d248b1b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26270330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keeler, Jarrod A</creatorcontrib><creatorcontrib>Patki, Aniruddha</creatorcontrib><creatorcontrib>Woodard, Charles R</creatorcontrib><creatorcontrib>Frank-Ito, Dennis O</creatorcontrib><title>A Computational Study of Nasal Spray Deposition Pattern in Four Ethnic Groups</title><title>Journal of aerosol medicine</title><addtitle>J Aerosol Med Pulm Drug Deliv</addtitle><description>Very little is known about the role of nasal morphology due to ethnic variation on particle deposition pattern in the sinonasal cavity. This preliminary study utilizes computational fluid dynamics (CFD) modeling to investigate sinonasal airway morphology and deposition patterns of intranasal sprayed particles in the nose and sinuses of individuals from four different ethnic groups: African American (Black); Asian; Caucasian; and Latin American.
Sixteen subjects (four from each ethnic group) with "normal" sinus protocol computed tomography (CT) were selected for CFD analysis. Three-dimensional reconstruction of each subject's sinonasal cavity was created from their personal CT images. CFD simulations were carried out in ANSYS Fluent(™) in two phases: airflow phase was done by numerically solving the Navier-Stokes equations for steady state laminar inhalation; and particle dispersed phase was solved by tracking injected (sprayed) particles through the calculated airflow field. A total of 10,000 particle streams were released from each nostril, 1000 particles per diameter ranging from 5 μm to 50 μm, with size increments of 5 μm.
As reported in the literature, Caucasians (5.31 ± 0.42 cm(-1)) and Latin Americans (5.16 ± 0.40cm(-1)) had the highest surface area to volume ratio, while African Americans had highest nasal index (95.91 ± 2.22). Nasal resistance (NR) was highest among Caucasians (0.046 ± 0.008 Pa.s/mL) and Asians (0.042 ± 0.016Pa.s/mL). Asians and African Americans had the most regions with particle deposition for small (5 μm-15 μm) and large (20 μm-50 μm) particle sizes, respectively. Asians and Latin Americans individuals had the most consistent regional particle deposition pattern in the main nasal cavities within their respective ethnic groups.
Preliminary results from these ethnic groups investigated showed that Caucasians and Latin Americans had the least patent nasal cavity. Furthermore, Caucasians and African Americans had the lowest inter-subject consistency in regional particle deposition pattern; this may be due to greater inter-subject variability in their respective nasal vestibule morphology.</description><subject>Administration, Inhalation</subject><subject>Aerosols</subject><subject>Airway Resistance</subject><subject>Asian</subject><subject>Black or African American</subject><subject>Computer Simulation</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Hispanic or Latino</subject><subject>Humans</subject><subject>Hydrodynamics</subject><subject>Imaging, Three-Dimensional</subject><subject>Male</subject><subject>Models, Anatomic</subject><subject>Nasal Cavity - anatomy & histology</subject><subject>Nasal Cavity - diagnostic imaging</subject><subject>Nasal Cavity - physiology</subject><subject>Numerical Analysis, Computer-Assisted</subject><subject>Original Research</subject><subject>Paranasal Sinuses - anatomy & histology</subject><subject>Paranasal Sinuses - diagnostic imaging</subject><subject>Paranasal Sinuses - physiology</subject><subject>Particle Size</subject><subject>Pharmaceutical Preparations - administration & dosage</subject><subject>Radiographic Image Interpretation, Computer-Assisted</subject><subject>Respiration</subject><subject>Tomography, Spiral Computed</subject><subject>White People</subject><issn>1941-2711</issn><issn>1941-2703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkctr3DAQh0VJaV699hgEvfSyW40elnQJhG1ekKSFJGchy3LjxbZcSQ7sfx-bTZa2p5wkMZ9-zMyH0BcgSyBKf1_bblhSAnwJlIgP6AA0hwWVhO3t7gD76DClNSEF8IJ9Qvu0mAlGDtDtGV6FbhizzU3obYvv81htcKjxnU3zc4h2g3_4IaRmJvAvm7OPPW56fBHGiM_zU984fBnDOKRj9LG2bfKfX88j9Hhx_rC6Wtz8vLxend0snACZF0oz6gin1nMrXV2A9pRboYS2JQBnlaeCFqoutKyok4pXrCSugIpyVUJJ2BE63eYOY9n5yvk-R9uaITadjRsTbGP-rfTNk_kdng1XQkgFU8C314AY_ow-ZdM1yfm2tb0PYzIw9cI1Z_wdqJRaqUIKPqFf_0PX04qmrW4pQSnTdKKWW8rFkFL09a5vIGaWamapZpZqZqnTh5O_p93hbxbZCyY3nG8</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Keeler, Jarrod A</creator><creator>Patki, Aniruddha</creator><creator>Woodard, Charles R</creator><creator>Frank-Ito, Dennis O</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>201604</creationdate><title>A Computational Study of Nasal Spray Deposition Pattern in Four Ethnic Groups</title><author>Keeler, Jarrod A ; Patki, Aniruddha ; Woodard, Charles R ; Frank-Ito, Dennis O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-8932c042ae4a7cf619e24a5859ab1143de25268f697d2c784d3b0c61d248b1b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Administration, Inhalation</topic><topic>Aerosols</topic><topic>Airway Resistance</topic><topic>Asian</topic><topic>Black or African American</topic><topic>Computer Simulation</topic><topic>Ethnicity</topic><topic>Female</topic><topic>Hispanic or Latino</topic><topic>Humans</topic><topic>Hydrodynamics</topic><topic>Imaging, Three-Dimensional</topic><topic>Male</topic><topic>Models, Anatomic</topic><topic>Nasal Cavity - anatomy & histology</topic><topic>Nasal Cavity - diagnostic imaging</topic><topic>Nasal Cavity - physiology</topic><topic>Numerical Analysis, Computer-Assisted</topic><topic>Original Research</topic><topic>Paranasal Sinuses - anatomy & histology</topic><topic>Paranasal Sinuses - diagnostic imaging</topic><topic>Paranasal Sinuses - physiology</topic><topic>Particle Size</topic><topic>Pharmaceutical Preparations - administration & dosage</topic><topic>Radiographic Image Interpretation, Computer-Assisted</topic><topic>Respiration</topic><topic>Tomography, Spiral Computed</topic><topic>White People</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keeler, Jarrod A</creatorcontrib><creatorcontrib>Patki, Aniruddha</creatorcontrib><creatorcontrib>Woodard, Charles R</creatorcontrib><creatorcontrib>Frank-Ito, Dennis O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of aerosol medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keeler, Jarrod A</au><au>Patki, Aniruddha</au><au>Woodard, Charles R</au><au>Frank-Ito, Dennis O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Computational Study of Nasal Spray Deposition Pattern in Four Ethnic Groups</atitle><jtitle>Journal of aerosol medicine</jtitle><addtitle>J Aerosol Med Pulm Drug Deliv</addtitle><date>2016-04</date><risdate>2016</risdate><volume>29</volume><issue>2</issue><spage>153</spage><epage>166</epage><pages>153-166</pages><issn>1941-2711</issn><eissn>1941-2703</eissn><abstract>Very little is known about the role of nasal morphology due to ethnic variation on particle deposition pattern in the sinonasal cavity. This preliminary study utilizes computational fluid dynamics (CFD) modeling to investigate sinonasal airway morphology and deposition patterns of intranasal sprayed particles in the nose and sinuses of individuals from four different ethnic groups: African American (Black); Asian; Caucasian; and Latin American.
Sixteen subjects (four from each ethnic group) with "normal" sinus protocol computed tomography (CT) were selected for CFD analysis. Three-dimensional reconstruction of each subject's sinonasal cavity was created from their personal CT images. CFD simulations were carried out in ANSYS Fluent(™) in two phases: airflow phase was done by numerically solving the Navier-Stokes equations for steady state laminar inhalation; and particle dispersed phase was solved by tracking injected (sprayed) particles through the calculated airflow field. A total of 10,000 particle streams were released from each nostril, 1000 particles per diameter ranging from 5 μm to 50 μm, with size increments of 5 μm.
As reported in the literature, Caucasians (5.31 ± 0.42 cm(-1)) and Latin Americans (5.16 ± 0.40cm(-1)) had the highest surface area to volume ratio, while African Americans had highest nasal index (95.91 ± 2.22). Nasal resistance (NR) was highest among Caucasians (0.046 ± 0.008 Pa.s/mL) and Asians (0.042 ± 0.016Pa.s/mL). Asians and African Americans had the most regions with particle deposition for small (5 μm-15 μm) and large (20 μm-50 μm) particle sizes, respectively. Asians and Latin Americans individuals had the most consistent regional particle deposition pattern in the main nasal cavities within their respective ethnic groups.
Preliminary results from these ethnic groups investigated showed that Caucasians and Latin Americans had the least patent nasal cavity. Furthermore, Caucasians and African Americans had the lowest inter-subject consistency in regional particle deposition pattern; this may be due to greater inter-subject variability in their respective nasal vestibule morphology.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>26270330</pmid><doi>10.1089/jamp.2014.1205</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Inhalation Aerosols Airway Resistance Asian Black or African American Computer Simulation Ethnicity Female Hispanic or Latino Humans Hydrodynamics Imaging, Three-Dimensional Male Models, Anatomic Nasal Cavity - anatomy & histology Nasal Cavity - diagnostic imaging Nasal Cavity - physiology Numerical Analysis, Computer-Assisted Original Research Paranasal Sinuses - anatomy & histology Paranasal Sinuses - diagnostic imaging Paranasal Sinuses - physiology Particle Size Pharmaceutical Preparations - administration & dosage Radiographic Image Interpretation, Computer-Assisted Respiration Tomography, Spiral Computed White People |
| title | A Computational Study of Nasal Spray Deposition Pattern in Four Ethnic Groups |
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