Age‐associated de‐repression of retrotransposons in the Drosophila fat body, its potential cause and consequence

Summary Eukaryotic genomes contain transposable elements (TE) that can move into new locations upon activation. Since uncontrolled transposition of TEs, including the retrotransposons and DNA transposons, can lead to DNA breaks and genomic instability, multiple mechanisms, including heterochromatin‐...

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Veröffentlicht in:	Aging cell 2016-06, Vol.15 (3), p.542-552
Hauptverfasser:	Chen, Haiyang, Zheng, Xiaobin, Xiao, Danqing, Zheng, Yixian
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - genetics Analysis Animals Deoxyribonucleic acid DNA DNA damage DNA Damage - genetics Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila Proteins - metabolism Fat Body - metabolism Gene Expression Regulation, Developmental Genomics heterochromatin Heterochromatin - metabolism Histones - metabolism Insects lamin Dm0 Lamins - metabolism Lamin‐B Lysine - metabolism Methylation Models, Biological Original Retroelements - genetics retrotransposons Transposons
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