Optogenetic approach for functional assays of the cardiovascular system by light activation of the vascular smooth muscle

Abstract Cardiovascular diseases are the major challenge to modern medicine. Intervention to cardiovascular cells is crucial for treatment of the diseases. Here we report a novel intervention to vascular smooth muscle (VSM) cells by optogenetics. Channelrhodopsin in a tandem with YFP was selectively...

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Veröffentlicht in:	Vascular pharmacology 2015-08, Vol.71, p.192-200
Hauptverfasser:	Wu, Yang, Li, Shan-Shan, Jin, Xin, Cui, Ningren, Zhang, Shuang, Jiang, Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - metabolism Arteries - metabolism Cardiovascular Cardiovascular rhodopsin Cardiovascular System - metabolism Channelrhodopsin Female Male Mice Mice, Transgenic Muscle, Smooth, Vascular - metabolism Optogenetics Optogenetics - methods Organ Culture Techniques Transgenic mice Vascular smooth muscle cells Vasoconstriction - physiology
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