Dendritic cell-based cancer immunotherapy for colorectal cancer
Colorectal cancer(CRC) is one of the most common cancers and a leading cause of cancer-related mortality worldwide. Although systemic therapy is the standard care for patients with recurrent or metastatic CRC, the prognosis is extremely poor. The optimal sequence of therapy remains unknown. Therefor...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2016-05, Vol.22 (17), p.4275-4286 |
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| container_title | World journal of gastroenterology : WJG |
| container_volume | 22 |
| creator | Kajihara, Mikio Takakura, Kazuki Kanai, Tomoya Ito, Zensho Saito, Keisuke Takami, Shinichiro Shimodaira, Shigetaka Okamoto, Masato Ohkusa, Toshifumi Koido, Shigeo |
| description | Colorectal cancer(CRC) is one of the most common cancers and a leading cause of cancer-related mortality worldwide. Although systemic therapy is the standard care for patients with recurrent or metastatic CRC, the prognosis is extremely poor. The optimal sequence of therapy remains unknown. Therefore, alternative strategies, such as immunotherapy, are needed for patients with advanced CRC. This review summarizes evidence from dendritic cell-based cancer immunotherapy strategies that are currently in clinical trials. In addition, we discuss the possibility of antitumor immune responses through immunoinhibitory PD-1/PD-L1 pathway blockade in CRC patients. |
| doi_str_mv | 10.3748/wjg.v22.i17.4275 |
| format | Article |
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Although systemic therapy is the standard care for patients with recurrent or metastatic CRC, the prognosis is extremely poor. The optimal sequence of therapy remains unknown. Therefore, alternative strategies, such as immunotherapy, are needed for patients with advanced CRC. This review summarizes evidence from dendritic cell-based cancer immunotherapy strategies that are currently in clinical trials. In addition, we discuss the possibility of antitumor immune responses through immunoinhibitory PD-1/PD-L1 pathway blockade in CRC patients.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v22.i17.4275</identifier><identifier>PMID: 27158196</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>B7-H1 Antigen - antagonists & inhibitors ; cancer;Dendritic ; Carcinoembryonic Antigen - immunology ; cell;Cancer ; Colorectal ; Colorectal Neoplasms - immunology ; Colorectal Neoplasms - therapy ; Dendritic Cells - immunology ; Humans ; Immunotherapy - methods ; immunotherapy;Cytotoxic ; inhibi ; lymphocyte;Immunecheckpoint ; Melanoma-Specific Antigens - immunology ; Programmed Cell Death 1 Receptor - antagonists & inhibitors ; T-Lymphocytes, Cytotoxic - immunology ; Topic Highlight ; WT1 Proteins - immunology</subject><ispartof>World journal of gastroenterology : WJG, 2016-05, Vol.22 (17), p.4275-4286</ispartof><rights>The Author(s) 2016. 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In addition, we discuss the possibility of antitumor immune responses through immunoinhibitory PD-1/PD-L1 pathway blockade in CRC patients.</description><subject>B7-H1 Antigen - antagonists & inhibitors</subject><subject>cancer;Dendritic</subject><subject>Carcinoembryonic Antigen - immunology</subject><subject>cell;Cancer</subject><subject>Colorectal</subject><subject>Colorectal Neoplasms - immunology</subject><subject>Colorectal Neoplasms - therapy</subject><subject>Dendritic Cells - immunology</subject><subject>Humans</subject><subject>Immunotherapy - methods</subject><subject>immunotherapy;Cytotoxic</subject><subject>inhibi</subject><subject>lymphocyte;Immunecheckpoint</subject><subject>Melanoma-Specific Antigens - immunology</subject><subject>Programmed Cell Death 1 Receptor - antagonists & inhibitors</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Topic Highlight</subject><subject>WT1 Proteins - immunology</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM9PwyAUx4nR6JzePZkevXTCAwZcNMbfiYkXPRNK6YZpy4RO438vjXNRkhdI-Lwvjw9CJwTPqGDy_PNtMfsAmHkiZgwE30ETAKJKkAzvognBWJSKgjhAhym9YQyUcthHByAIl0TNJ-jyxvV19IO3hXVtW1YmubqwprcuFr7r1n0Yli6a1VfRhFjY0Ibo7GDaDXOE9hrTJne82afo9e725fqhfHq-f7y-eiotY3go57apJFXWWmCGE8FZwyiMY4CShkPF6byhdSWclUCsIthRoDWD2tViThidoouf3NW66lxtXT9E0-pV9J2JXzoYr__f9H6pF-FDM5mjc03R2SYghve1S4PufBq_bHoX1kkTIYXKdgjOKP5BbQwpRddsnyFYj9519q6zd52969F7bjn9O9624Vd0Bugmcxn6xbvvF1tGYTkuxTGTTHGWi-eT5Jh-A4I8j2g</recordid><startdate>20160507</startdate><enddate>20160507</enddate><creator>Kajihara, Mikio</creator><creator>Takakura, Kazuki</creator><creator>Kanai, Tomoya</creator><creator>Ito, Zensho</creator><creator>Saito, Keisuke</creator><creator>Takami, Shinichiro</creator><creator>Shimodaira, Shigetaka</creator><creator>Okamoto, Masato</creator><creator>Ohkusa, Toshifumi</creator><creator>Koido, Shigeo</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160507</creationdate><title>Dendritic cell-based cancer immunotherapy for colorectal cancer</title><author>Kajihara, Mikio ; 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| issn | 1007-9327 2219-2840 |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | B7-H1 Antigen - antagonists & inhibitors cancer Dendritic Carcinoembryonic Antigen - immunology cell Cancer Colorectal Colorectal Neoplasms - immunology Colorectal Neoplasms - therapy Dendritic Cells - immunology Humans Immunotherapy - methods immunotherapy Cytotoxic inhibi lymphocyte Immunecheckpoint Melanoma-Specific Antigens - immunology Programmed Cell Death 1 Receptor - antagonists & inhibitors T-Lymphocytes, Cytotoxic - immunology Topic Highlight WT1 Proteins - immunology |
| title | Dendritic cell-based cancer immunotherapy for colorectal cancer |
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