Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study
Background Arterial stiffness may contribute to depression via cerebral microvascular damage, but evidence for this is scarce. We therefore investigated whether arterial stiffness is associated with depressive symptoms and whether cerebral small vessel disease contributes to this association. Method...
Gespeichert in:
| Veröffentlicht in: | Journal of psychiatry & neuroscience 2016-05, Vol.41 (3), p.162-168 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 168 |
|---|---|
| container_issue | 3 |
| container_start_page | 162 |
| container_title | Journal of psychiatry & neuroscience |
| container_volume | 41 |
| creator | van Sloten, Thomas T., MD, PhD Henry, Ronald M.A., MD, PhD Stehouwer, Coen D.A., MD, PhD Mitchell, Gary F., MD Sigurdsson, Sigurdur, MSc Gudnason, Vilmundur, MD, PhD van Buchem, Mark A., MD, PhD Jonsson, Palmi V., MD Garcia, Melissa E., MPH Harris, Tamara B., MD, MS Launer, Lenore J., PhD Levey, Andrew S., MD |
| description | Background Arterial stiffness may contribute to depression via cerebral microvascular damage, but evidence for this is scarce. We therefore investigated whether arterial stiffness is associated with depressive symptoms and whether cerebral small vessel disease contributes to this association. Methods This cross-sectional study included a subset of participants from the AGES-Reykjavik study second examination round, which was conducted from 2007 to 2011. Arterial stiffness (carotid–femoral pulse wave velocity [CFPWV]), depressive symptoms (15-item geriatric depression scale [GDS-15]) and cerebral small vessel disease (MRI) were determined. Manifestations of cerebral small vessel disease included higher white matter hyperintensity volume, subcortical infarcts, cerebral microbleeds, Virchow–Robin spaces and lower total brain parenchyma volume. Results We included 2058 participants (mean age 79.6 yr; 59.0% women) in our analyses. Higher CFPWV was associated with a higher GDS-15 score, after adjustment for potential confounders (β 0.096, 95% confidence interval [CI] 0.005–0.187). Additional adjustment for white matter hyperintensity volume or subcortical infarcts attenuated the association between CFPWV and the GDS-15 score, which became nonsignificant ( p > 0.05). Formal mediation tests showed that the attenuating effects of white matter hyperintensity volume and subcortical infarcts were statistically significant. Virchow–Robin spaces, cerebral microbleeds and cerebral atrophy did not explain the association between CFPWV and depressive symptoms. Limitations Our study was limited by its cross-sectional design, which precludes any conclusions about causal mediation. Depressive symptoms were assessed by a self-report questionnaire. Conclusion Greater arterial stiffness is associated with more depressive symptoms; this association is partly accounted for by white matter hyperintensity volume and subcortical infarcts. This study supports the hypothesis that arterial stiffness leads to depression in part via cerebral small vessel disease. |
| doi_str_mv | 10.1503/jpn.140334 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4853207</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A454361041</galeid><els_id>1_s2_0_S1180488216300336</els_id><sourcerecordid>A454361041</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-a4ee0d4ca1adfbfca95e3a6bb19eb9fd1772b54a12ceb29c6b1e18deff6836563</originalsourceid><addsrcrecordid>eNqV01Fv0zAQAOAIgdgYvPADkAUSAkSKnThpygNSNY0xaQJphWfLcc6tu8TufE6hf4Tfi7ONdUV9QXmIk3y-S3J3SfKc0REraP5hubIjxmme8wfJIeNVlWY85w_jmlU0jdfZQfIEcUkpzSgrHicHWVnQIm45TH5PEZ0yMhhnkdQQfgJYIn0Ab2RLMBitLSC-Jw2sfFyYNRDcdKvgOiTSNkSBh9oPtpNtS9bRQEsagyARPhLlHWKKoIYMUWljG2PnSLR3HQkLINPTk1l6AZvLpVybSzILfbN5mjzSskV4dns-Sn58Pvl-_CU9_3Z6djw9T1U5yUIqOQBtuJJMNrrWSk4KyGVZ12wC9UQ3bDzO6oJLlimos4kqawasakDrssrLosyPkk83cVd93UGjwIb4KWLlTSf9RjhpxO4TaxZi7taCV0We0XEM8OY2gHdXPWAQnUEFbSstuB4FG1dFNtSER_rqH7p0vY__ZFATFgnNq62ayxaEsdrFvGoIKqa84HnJKGdRpXvUHCzEl3QWtIm3d_zLPV6tzJW4j0Z7UDwa6IzaG_XtzoZoAvwKc9kjirPZxX_Yr7v29T27ANmGBbq2v27SXfjuBl53mQd9VzlGxTAbIs6GuJmNiF_cr_Ud_TsM22aA2HFrA16o1lijZHsJG8BttQRmgorZMF7DdLEypzFDmf8BD5Ed-w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1791884038</pqid></control><display><type>article</type><title>Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>van Sloten, Thomas T., MD, PhD ; Henry, Ronald M.A., MD, PhD ; Stehouwer, Coen D.A., MD, PhD ; Mitchell, Gary F., MD ; Sigurdsson, Sigurdur, MSc ; Gudnason, Vilmundur, MD, PhD ; van Buchem, Mark A., MD, PhD ; Jonsson, Palmi V., MD ; Garcia, Melissa E., MPH ; Harris, Tamara B., MD, MS ; Launer, Lenore J., PhD ; Levey, Andrew S., MD</creator><creatorcontrib>van Sloten, Thomas T., MD, PhD ; Henry, Ronald M.A., MD, PhD ; Stehouwer, Coen D.A., MD, PhD ; Mitchell, Gary F., MD ; Sigurdsson, Sigurdur, MSc ; Gudnason, Vilmundur, MD, PhD ; van Buchem, Mark A., MD, PhD ; Jonsson, Palmi V., MD ; Garcia, Melissa E., MPH ; Harris, Tamara B., MD, MS ; Launer, Lenore J., PhD ; Levey, Andrew S., MD</creatorcontrib><description>Background Arterial stiffness may contribute to depression via cerebral microvascular damage, but evidence for this is scarce. We therefore investigated whether arterial stiffness is associated with depressive symptoms and whether cerebral small vessel disease contributes to this association. Methods This cross-sectional study included a subset of participants from the AGES-Reykjavik study second examination round, which was conducted from 2007 to 2011. Arterial stiffness (carotid–femoral pulse wave velocity [CFPWV]), depressive symptoms (15-item geriatric depression scale [GDS-15]) and cerebral small vessel disease (MRI) were determined. Manifestations of cerebral small vessel disease included higher white matter hyperintensity volume, subcortical infarcts, cerebral microbleeds, Virchow–Robin spaces and lower total brain parenchyma volume. Results We included 2058 participants (mean age 79.6 yr; 59.0% women) in our analyses. Higher CFPWV was associated with a higher GDS-15 score, after adjustment for potential confounders (β 0.096, 95% confidence interval [CI] 0.005–0.187). Additional adjustment for white matter hyperintensity volume or subcortical infarcts attenuated the association between CFPWV and the GDS-15 score, which became nonsignificant ( p > 0.05). Formal mediation tests showed that the attenuating effects of white matter hyperintensity volume and subcortical infarcts were statistically significant. Virchow–Robin spaces, cerebral microbleeds and cerebral atrophy did not explain the association between CFPWV and depressive symptoms. Limitations Our study was limited by its cross-sectional design, which precludes any conclusions about causal mediation. Depressive symptoms were assessed by a self-report questionnaire. Conclusion Greater arterial stiffness is associated with more depressive symptoms; this association is partly accounted for by white matter hyperintensity volume and subcortical infarcts. This study supports the hypothesis that arterial stiffness leads to depression in part via cerebral small vessel disease.</description><identifier>ISSN: 1180-4882</identifier><identifier>EISSN: 1488-2434</identifier><identifier>DOI: 10.1503/jpn.140334</identifier><identifier>PMID: 26505140</identifier><identifier>CODEN: JPNEEF</identifier><language>eng</language><publisher>Canada: Joule Inc</publisher><subject>Aged ; Arteriosclerosis ; Atrophy ; Brain - diagnostic imaging ; Carotid Arteries - physiopathology ; Cerebral Hemorrhage - diagnostic imaging ; Cerebral Hemorrhage - physiopathology ; Cerebral Hemorrhage - psychology ; Cerebral Small Vessel Diseases - diagnostic imaging ; Cerebral Small Vessel Diseases - physiopathology ; Cerebral Small Vessel Diseases - psychology ; Cerebrovascular disease ; Cross-Sectional Studies ; Depression - diagnostic imaging ; Depression - physiopathology ; Depression, Mental ; Female ; Femoral Artery - physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Medical Education ; Mental depression ; Physiological aspects ; Psychiatry ; Pulse Wave Analysis ; Research Paper ; Self Report ; Studies ; Vascular Stiffness ; Vein & artery diseases ; White Matter - diagnostic imaging</subject><ispartof>Journal of psychiatry & neuroscience, 2016-05, Vol.41 (3), p.162-168</ispartof><rights>Joule Inc. or its licensors</rights><rights>COPYRIGHT 2016 Joule Inc.</rights><rights>Copyright 8872147 Canada Inc. May 2016</rights><rights>2016 Joule Inc. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a4ee0d4ca1adfbfca95e3a6bb19eb9fd1772b54a12ceb29c6b1e18deff6836563</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853207/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853207/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26505140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Sloten, Thomas T., MD, PhD</creatorcontrib><creatorcontrib>Henry, Ronald M.A., MD, PhD</creatorcontrib><creatorcontrib>Stehouwer, Coen D.A., MD, PhD</creatorcontrib><creatorcontrib>Mitchell, Gary F., MD</creatorcontrib><creatorcontrib>Sigurdsson, Sigurdur, MSc</creatorcontrib><creatorcontrib>Gudnason, Vilmundur, MD, PhD</creatorcontrib><creatorcontrib>van Buchem, Mark A., MD, PhD</creatorcontrib><creatorcontrib>Jonsson, Palmi V., MD</creatorcontrib><creatorcontrib>Garcia, Melissa E., MPH</creatorcontrib><creatorcontrib>Harris, Tamara B., MD, MS</creatorcontrib><creatorcontrib>Launer, Lenore J., PhD</creatorcontrib><creatorcontrib>Levey, Andrew S., MD</creatorcontrib><title>Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study</title><title>Journal of psychiatry & neuroscience</title><addtitle>J Psychiatry Neurosci</addtitle><description>Background Arterial stiffness may contribute to depression via cerebral microvascular damage, but evidence for this is scarce. We therefore investigated whether arterial stiffness is associated with depressive symptoms and whether cerebral small vessel disease contributes to this association. Methods This cross-sectional study included a subset of participants from the AGES-Reykjavik study second examination round, which was conducted from 2007 to 2011. Arterial stiffness (carotid–femoral pulse wave velocity [CFPWV]), depressive symptoms (15-item geriatric depression scale [GDS-15]) and cerebral small vessel disease (MRI) were determined. Manifestations of cerebral small vessel disease included higher white matter hyperintensity volume, subcortical infarcts, cerebral microbleeds, Virchow–Robin spaces and lower total brain parenchyma volume. Results We included 2058 participants (mean age 79.6 yr; 59.0% women) in our analyses. Higher CFPWV was associated with a higher GDS-15 score, after adjustment for potential confounders (β 0.096, 95% confidence interval [CI] 0.005–0.187). Additional adjustment for white matter hyperintensity volume or subcortical infarcts attenuated the association between CFPWV and the GDS-15 score, which became nonsignificant ( p > 0.05). Formal mediation tests showed that the attenuating effects of white matter hyperintensity volume and subcortical infarcts were statistically significant. Virchow–Robin spaces, cerebral microbleeds and cerebral atrophy did not explain the association between CFPWV and depressive symptoms. Limitations Our study was limited by its cross-sectional design, which precludes any conclusions about causal mediation. Depressive symptoms were assessed by a self-report questionnaire. Conclusion Greater arterial stiffness is associated with more depressive symptoms; this association is partly accounted for by white matter hyperintensity volume and subcortical infarcts. This study supports the hypothesis that arterial stiffness leads to depression in part via cerebral small vessel disease.</description><subject>Aged</subject><subject>Arteriosclerosis</subject><subject>Atrophy</subject><subject>Brain - diagnostic imaging</subject><subject>Carotid Arteries - physiopathology</subject><subject>Cerebral Hemorrhage - diagnostic imaging</subject><subject>Cerebral Hemorrhage - physiopathology</subject><subject>Cerebral Hemorrhage - psychology</subject><subject>Cerebral Small Vessel Diseases - diagnostic imaging</subject><subject>Cerebral Small Vessel Diseases - physiopathology</subject><subject>Cerebral Small Vessel Diseases - psychology</subject><subject>Cerebrovascular disease</subject><subject>Cross-Sectional Studies</subject><subject>Depression - diagnostic imaging</subject><subject>Depression - physiopathology</subject><subject>Depression, Mental</subject><subject>Female</subject><subject>Femoral Artery - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical Education</subject><subject>Mental depression</subject><subject>Physiological aspects</subject><subject>Psychiatry</subject><subject>Pulse Wave Analysis</subject><subject>Research Paper</subject><subject>Self Report</subject><subject>Studies</subject><subject>Vascular Stiffness</subject><subject>Vein & artery diseases</subject><subject>White Matter - diagnostic imaging</subject><issn>1180-4882</issn><issn>1488-2434</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqV01Fv0zAQAOAIgdgYvPADkAUSAkSKnThpygNSNY0xaQJphWfLcc6tu8TufE6hf4Tfi7ONdUV9QXmIk3y-S3J3SfKc0REraP5hubIjxmme8wfJIeNVlWY85w_jmlU0jdfZQfIEcUkpzSgrHicHWVnQIm45TH5PEZ0yMhhnkdQQfgJYIn0Ab2RLMBitLSC-Jw2sfFyYNRDcdKvgOiTSNkSBh9oPtpNtS9bRQEsagyARPhLlHWKKoIYMUWljG2PnSLR3HQkLINPTk1l6AZvLpVybSzILfbN5mjzSskV4dns-Sn58Pvl-_CU9_3Z6djw9T1U5yUIqOQBtuJJMNrrWSk4KyGVZ12wC9UQ3bDzO6oJLlimos4kqawasakDrssrLosyPkk83cVd93UGjwIb4KWLlTSf9RjhpxO4TaxZi7taCV0We0XEM8OY2gHdXPWAQnUEFbSstuB4FG1dFNtSER_rqH7p0vY__ZFATFgnNq62ayxaEsdrFvGoIKqa84HnJKGdRpXvUHCzEl3QWtIm3d_zLPV6tzJW4j0Z7UDwa6IzaG_XtzoZoAvwKc9kjirPZxX_Yr7v29T27ANmGBbq2v27SXfjuBl53mQd9VzlGxTAbIs6GuJmNiF_cr_Ud_TsM22aA2HFrA16o1lijZHsJG8BttQRmgorZMF7DdLEypzFDmf8BD5Ed-w</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>van Sloten, Thomas T., MD, PhD</creator><creator>Henry, Ronald M.A., MD, PhD</creator><creator>Stehouwer, Coen D.A., MD, PhD</creator><creator>Mitchell, Gary F., MD</creator><creator>Sigurdsson, Sigurdur, MSc</creator><creator>Gudnason, Vilmundur, MD, PhD</creator><creator>van Buchem, Mark A., MD, PhD</creator><creator>Jonsson, Palmi V., MD</creator><creator>Garcia, Melissa E., MPH</creator><creator>Harris, Tamara B., MD, MS</creator><creator>Launer, Lenore J., PhD</creator><creator>Levey, Andrew S., MD</creator><general>Joule Inc</general><general>CMA Impact, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>8FV</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M3G</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160501</creationdate><title>Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study</title><author>van Sloten, Thomas T., MD, PhD ; Henry, Ronald M.A., MD, PhD ; Stehouwer, Coen D.A., MD, PhD ; Mitchell, Gary F., MD ; Sigurdsson, Sigurdur, MSc ; Gudnason, Vilmundur, MD, PhD ; van Buchem, Mark A., MD, PhD ; Jonsson, Palmi V., MD ; Garcia, Melissa E., MPH ; Harris, Tamara B., MD, MS ; Launer, Lenore J., PhD ; Levey, Andrew S., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-a4ee0d4ca1adfbfca95e3a6bb19eb9fd1772b54a12ceb29c6b1e18deff6836563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Arteriosclerosis</topic><topic>Atrophy</topic><topic>Brain - diagnostic imaging</topic><topic>Carotid Arteries - physiopathology</topic><topic>Cerebral Hemorrhage - diagnostic imaging</topic><topic>Cerebral Hemorrhage - physiopathology</topic><topic>Cerebral Hemorrhage - psychology</topic><topic>Cerebral Small Vessel Diseases - diagnostic imaging</topic><topic>Cerebral Small Vessel Diseases - physiopathology</topic><topic>Cerebral Small Vessel Diseases - psychology</topic><topic>Cerebrovascular disease</topic><topic>Cross-Sectional Studies</topic><topic>Depression - diagnostic imaging</topic><topic>Depression - physiopathology</topic><topic>Depression, Mental</topic><topic>Female</topic><topic>Femoral Artery - physiopathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical Education</topic><topic>Mental depression</topic><topic>Physiological aspects</topic><topic>Psychiatry</topic><topic>Pulse Wave Analysis</topic><topic>Research Paper</topic><topic>Self Report</topic><topic>Studies</topic><topic>Vascular Stiffness</topic><topic>Vein & artery diseases</topic><topic>White Matter - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Sloten, Thomas T., MD, PhD</creatorcontrib><creatorcontrib>Henry, Ronald M.A., MD, PhD</creatorcontrib><creatorcontrib>Stehouwer, Coen D.A., MD, PhD</creatorcontrib><creatorcontrib>Mitchell, Gary F., MD</creatorcontrib><creatorcontrib>Sigurdsson, Sigurdur, MSc</creatorcontrib><creatorcontrib>Gudnason, Vilmundur, MD, PhD</creatorcontrib><creatorcontrib>van Buchem, Mark A., MD, PhD</creatorcontrib><creatorcontrib>Jonsson, Palmi V., MD</creatorcontrib><creatorcontrib>Garcia, Melissa E., MPH</creatorcontrib><creatorcontrib>Harris, Tamara B., MD, MS</creatorcontrib><creatorcontrib>Launer, Lenore J., PhD</creatorcontrib><creatorcontrib>Levey, Andrew S., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Canadian Business & Current Affairs Database</collection><collection>Canadian Business & Current Affairs Database (Alumni Edition)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>CBCA Reference & Current Events</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of psychiatry & neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Sloten, Thomas T., MD, PhD</au><au>Henry, Ronald M.A., MD, PhD</au><au>Stehouwer, Coen D.A., MD, PhD</au><au>Mitchell, Gary F., MD</au><au>Sigurdsson, Sigurdur, MSc</au><au>Gudnason, Vilmundur, MD, PhD</au><au>van Buchem, Mark A., MD, PhD</au><au>Jonsson, Palmi V., MD</au><au>Garcia, Melissa E., MPH</au><au>Harris, Tamara B., MD, MS</au><au>Launer, Lenore J., PhD</au><au>Levey, Andrew S., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study</atitle><jtitle>Journal of psychiatry & neuroscience</jtitle><addtitle>J Psychiatry Neurosci</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>41</volume><issue>3</issue><spage>162</spage><epage>168</epage><pages>162-168</pages><issn>1180-4882</issn><eissn>1488-2434</eissn><coden>JPNEEF</coden><abstract>Background Arterial stiffness may contribute to depression via cerebral microvascular damage, but evidence for this is scarce. We therefore investigated whether arterial stiffness is associated with depressive symptoms and whether cerebral small vessel disease contributes to this association. Methods This cross-sectional study included a subset of participants from the AGES-Reykjavik study second examination round, which was conducted from 2007 to 2011. Arterial stiffness (carotid–femoral pulse wave velocity [CFPWV]), depressive symptoms (15-item geriatric depression scale [GDS-15]) and cerebral small vessel disease (MRI) were determined. Manifestations of cerebral small vessel disease included higher white matter hyperintensity volume, subcortical infarcts, cerebral microbleeds, Virchow–Robin spaces and lower total brain parenchyma volume. Results We included 2058 participants (mean age 79.6 yr; 59.0% women) in our analyses. Higher CFPWV was associated with a higher GDS-15 score, after adjustment for potential confounders (β 0.096, 95% confidence interval [CI] 0.005–0.187). Additional adjustment for white matter hyperintensity volume or subcortical infarcts attenuated the association between CFPWV and the GDS-15 score, which became nonsignificant ( p > 0.05). Formal mediation tests showed that the attenuating effects of white matter hyperintensity volume and subcortical infarcts were statistically significant. Virchow–Robin spaces, cerebral microbleeds and cerebral atrophy did not explain the association between CFPWV and depressive symptoms. Limitations Our study was limited by its cross-sectional design, which precludes any conclusions about causal mediation. Depressive symptoms were assessed by a self-report questionnaire. Conclusion Greater arterial stiffness is associated with more depressive symptoms; this association is partly accounted for by white matter hyperintensity volume and subcortical infarcts. This study supports the hypothesis that arterial stiffness leads to depression in part via cerebral small vessel disease.</abstract><cop>Canada</cop><pub>Joule Inc</pub><pmid>26505140</pmid><doi>10.1503/jpn.140334</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1180-4882 |
| ispartof | Journal of psychiatry & neuroscience, 2016-05, Vol.41 (3), p.162-168 |
| issn | 1180-4882 1488-2434 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4853207 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Aged Arteriosclerosis Atrophy Brain - diagnostic imaging Carotid Arteries - physiopathology Cerebral Hemorrhage - diagnostic imaging Cerebral Hemorrhage - physiopathology Cerebral Hemorrhage - psychology Cerebral Small Vessel Diseases - diagnostic imaging Cerebral Small Vessel Diseases - physiopathology Cerebral Small Vessel Diseases - psychology Cerebrovascular disease Cross-Sectional Studies Depression - diagnostic imaging Depression - physiopathology Depression, Mental Female Femoral Artery - physiopathology Humans Magnetic Resonance Imaging Male Medical Education Mental depression Physiological aspects Psychiatry Pulse Wave Analysis Research Paper Self Report Studies Vascular Stiffness Vein & artery diseases White Matter - diagnostic imaging |
| title | Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T21%3A15%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Associations%20between%20arterial%20stiffness,%20depressive%20symptoms%20and%20cerebral%20small%20vessel%20disease:%20cross-sectional%20findings%20from%20the%20AGES-Reykjavik%20Study&rft.jtitle=Journal%20of%20psychiatry%20&%20neuroscience&rft.au=van%20Sloten,%20Thomas%20T.,%20MD,%20PhD&rft.date=2016-05-01&rft.volume=41&rft.issue=3&rft.spage=162&rft.epage=168&rft.pages=162-168&rft.issn=1180-4882&rft.eissn=1488-2434&rft.coden=JPNEEF&rft_id=info:doi/10.1503/jpn.140334&rft_dat=%3Cgale_pubme%3EA454361041%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1791884038&rft_id=info:pmid/26505140&rft_galeid=A454361041&rft_els_id=1_s2_0_S1180488216300336&rfr_iscdi=true |