Optimization of a methamphetamine conjugate vaccine for antibody production in mice

There are still no approved medications for treating patients who abuse methamphetamine. Active vaccines for treating abuse of nicotine and cocaine are in clinical studies, but have not proven effective seemingly due to inadequate anti-drug antibody production. The current studies aimed to optimize...

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Veröffentlicht in:	International immunopharmacology 2016-06, Vol.35, p.137-141
Hauptverfasser:	Stevens, Misty W., Gunnell, Melinda G., Tawney, Rachel, Owens, S. Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - administration & dosage Aluminum Hydroxide - administration & dosage Amphetamine-Related Disorders - drug therapy Amphetamine-Related Disorders - immunology Animals Antibody Affinity Antibody Formation Drug abuse Female Glucosides - administration & dosage Hapten density Humans Lipid A - administration & dosage Methamphetamine Methamphetamine - analogs & derivatives Methamphetamine - immunology Mice Mice, Inbred BALB C Preclinical study Therapeutic vaccine Vaccination Vaccines, Conjugate - immunology
Online-Zugang:	Volltext
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