Long-Term Blockade of Cocaine Self-Administration and Locomotor Activation in Rats by an Adenoviral Vector-Delivered Cocaine Hydrolase

A promising approach in treating cocaine abuse is to metabolize cocaine in the blood using a mutated butyrylcholinesterase (BChE) that functions as a cocaine hydrolase (CocH). In rats, a helper-dependent adenoviral (hdAD) vector-mediated delivery of CocH abolished ongoing cocaine use and cocaine-pri...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2016-05, Vol.357 (2), p.375-381
Hauptverfasser:	Smethells, John R, Swalve, Natashia, Brimijoin, Stephen, Gao, Yang, Parks, Robin J, Greer, Adam, Carroll, Marilyn E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Anxiety - genetics Anxiety - psychology Behavioral Pharmacology Carboxylic Ester Hydrolases - blood Carboxylic Ester Hydrolases - genetics Cocaine - pharmacology Cocaine-Related Disorders - psychology Cocaine-Related Disorders - therapy Diet Dose-Response Relationship, Drug Genetic Therapy - methods Genetic Vectors Male Motor Activity - drug effects Rats Rats, Wistar Reward Self Administration Weight Gain - drug effects
Online-Zugang:	Volltext
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