Risk factors for late defecation and its association with the outcomes of critically ill patients: a retrospective observational study
Late defecation was recently reported to be associated with worse clinical outcomes in critically ill patients. However, more research is needed to examine the causes and clinical significance of late defecation. The objectives of this study were to investigate the risk factors for late defecation a...
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| Veröffentlicht in: | Journal of intensive care 2016-04, Vol.4 (33), p.33-33, Article 33 |
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| creator | Fukuda, Shinya Miyauchi, Takashi Fujita, Motoki Oda, Yasutaka Todani, Masaki Kawamura, Yoshikatsu Kaneda, Kotaro Tsuruta, Ryosuke |
| description | Late defecation was recently reported to be associated with worse clinical outcomes in critically ill patients. However, more research is needed to examine the causes and clinical significance of late defecation. The objectives of this study were to investigate the risk factors for late defecation and its association with the outcomes of intensive care unit (ICU) patients.
Patients in an ICU for ≥7 days between January and December 2011 were retrospectively assessed. Based on the time between admission and the first defecation, they were assigned to early ( |
| doi_str_mv | 10.1186/s40560-016-0156-1 |
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Patients in an ICU for ≥7 days between January and December 2011 were retrospectively assessed. Based on the time between admission and the first defecation, they were assigned to early (<6 days; n = 186) or late (≥6 days; n = 96) defecation groups. Changes in clinical variables between admission and ICU day 7 were assessed to investigate the effects of late defecation. The clinical outcomes were ICU mortality, length of ICU stay, and length of mechanical ventilation.
Late enteral nutrition (odds ratio (OR) 3.42; 95 % confidence interval (CI) 1.88-6.22; P < 0.001), sedatives (OR 3.07; 95 % CI 1.71-5.52; P < 0.001), and surgery (OR 1.86; 95 % CI 1.01-3.42; P = 0.047) were the independent risk factors for late defecation. The median (interquartile) changes in body temperature (0.3 [-0.4 to 1.0] vs 0.7 [0.1 to 1.5] °C; P = 0.004), serum C-reactive protein concentration (1.6 [-0.5 to 6.6] vs 3.5 [0.7 to 8.5] mg/dL; P = 0.035), and Sequential Organ Failure Assessment score (-1 [-2 to 1] vs 0 [-1 to 2]; P = 0.008) between admission and ICU day 7 were significantly greater in the late defecation group than in the early defecation group. ICU stay was significantly longer in the late defecation group (12 [9 to 19] vs 16 [10 to 23] days; P = 0.021), whereas ICU mortality and the length of mechanical ventilation were similar in both groups.
Late enteral nutrition, sedatives, and surgery were independent the risk factors for late defecation in critically ill patients. Late defecation was associated with prolonged ICU stay.</description><identifier>ISSN: 2052-0492</identifier><identifier>EISSN: 2052-0492</identifier><identifier>DOI: 10.1186/s40560-016-0156-1</identifier><identifier>PMID: 27134753</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Analysis ; C-reactive protein ; Defecation ; Health aspects</subject><ispartof>Journal of intensive care, 2016-04, Vol.4 (33), p.33-33, Article 33</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>Fukuda et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-3309a47836734984e4631c5126c78599cb39ffb7965d7b9b96b59225edf5446a3</citedby><cites>FETCH-LOGICAL-c525t-3309a47836734984e4631c5126c78599cb39ffb7965d7b9b96b59225edf5446a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850650/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850650/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27134753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukuda, Shinya</creatorcontrib><creatorcontrib>Miyauchi, Takashi</creatorcontrib><creatorcontrib>Fujita, Motoki</creatorcontrib><creatorcontrib>Oda, Yasutaka</creatorcontrib><creatorcontrib>Todani, Masaki</creatorcontrib><creatorcontrib>Kawamura, Yoshikatsu</creatorcontrib><creatorcontrib>Kaneda, Kotaro</creatorcontrib><creatorcontrib>Tsuruta, Ryosuke</creatorcontrib><title>Risk factors for late defecation and its association with the outcomes of critically ill patients: a retrospective observational study</title><title>Journal of intensive care</title><addtitle>J Intensive Care</addtitle><description>Late defecation was recently reported to be associated with worse clinical outcomes in critically ill patients. However, more research is needed to examine the causes and clinical significance of late defecation. The objectives of this study were to investigate the risk factors for late defecation and its association with the outcomes of intensive care unit (ICU) patients.
Patients in an ICU for ≥7 days between January and December 2011 were retrospectively assessed. Based on the time between admission and the first defecation, they were assigned to early (<6 days; n = 186) or late (≥6 days; n = 96) defecation groups. Changes in clinical variables between admission and ICU day 7 were assessed to investigate the effects of late defecation. The clinical outcomes were ICU mortality, length of ICU stay, and length of mechanical ventilation.
Late enteral nutrition (odds ratio (OR) 3.42; 95 % confidence interval (CI) 1.88-6.22; P < 0.001), sedatives (OR 3.07; 95 % CI 1.71-5.52; P < 0.001), and surgery (OR 1.86; 95 % CI 1.01-3.42; P = 0.047) were the independent risk factors for late defecation. The median (interquartile) changes in body temperature (0.3 [-0.4 to 1.0] vs 0.7 [0.1 to 1.5] °C; P = 0.004), serum C-reactive protein concentration (1.6 [-0.5 to 6.6] vs 3.5 [0.7 to 8.5] mg/dL; P = 0.035), and Sequential Organ Failure Assessment score (-1 [-2 to 1] vs 0 [-1 to 2]; P = 0.008) between admission and ICU day 7 were significantly greater in the late defecation group than in the early defecation group. ICU stay was significantly longer in the late defecation group (12 [9 to 19] vs 16 [10 to 23] days; P = 0.021), whereas ICU mortality and the length of mechanical ventilation were similar in both groups.
Late enteral nutrition, sedatives, and surgery were independent the risk factors for late defecation in critically ill patients. Late defecation was associated with prolonged ICU stay.</description><subject>Analysis</subject><subject>C-reactive protein</subject><subject>Defecation</subject><subject>Health aspects</subject><issn>2052-0492</issn><issn>2052-0492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkl-LFSEYxoco2mXbD9BNCEF0M5uOf2bsIliW_sFCEHUtjvO64-aMJ3VOnC_Q587pbNs5ESKK_p5HfX2q6inBF4R04lVimAtcYyJK56ImD6rTBvOmxkw2Dw_mJ9V5SrcYY4I5FZ18XJ00LaGs5fS0-vnZpW_IapNDTMiGiLzOgAawYHR2YUZ6HpDLCemUgnH7tR8ujyiPgMKSTZggoWCRiS47o73fIec92hQU5pxeI40i5BjSBkx22yLqE8TtbyftUcrLsHtSPbLaJzi_G8-qr-_efrn6UF9_ev_x6vK6NrzhuaYUS83ajoqWMtkxYIISw0kjTNtxKU1PpbV9KwUf2l72UvRcNg2HwXLGhKZn1Zu972bpJxhMuWDUXm2im3TcqaCdOt6Z3ahuwlaxjmPBcTF4eWcQw_cFUlaTSwa81zOEJSnSdqJclTRNQZ__g96GJZYnr5QUtPweo3-pG-1BudmGcq5ZTdUl44TSlpHV6-I_VGkDTM6EGawr60eCFweCEbTPYwp-WYuejkGyB035oRTB3heDYLUGTe2DpkrQ1Bo0RYrm2WEV7xV_YkV_AYO8zak</recordid><startdate>20160429</startdate><enddate>20160429</enddate><creator>Fukuda, Shinya</creator><creator>Miyauchi, Takashi</creator><creator>Fujita, Motoki</creator><creator>Oda, Yasutaka</creator><creator>Todani, Masaki</creator><creator>Kawamura, Yoshikatsu</creator><creator>Kaneda, Kotaro</creator><creator>Tsuruta, Ryosuke</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160429</creationdate><title>Risk factors for late defecation and its association with the outcomes of critically ill patients: a retrospective observational study</title><author>Fukuda, Shinya ; Miyauchi, Takashi ; Fujita, Motoki ; Oda, Yasutaka ; Todani, Masaki ; Kawamura, Yoshikatsu ; Kaneda, Kotaro ; Tsuruta, Ryosuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-3309a47836734984e4631c5126c78599cb39ffb7965d7b9b96b59225edf5446a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Analysis</topic><topic>C-reactive protein</topic><topic>Defecation</topic><topic>Health aspects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukuda, Shinya</creatorcontrib><creatorcontrib>Miyauchi, Takashi</creatorcontrib><creatorcontrib>Fujita, Motoki</creatorcontrib><creatorcontrib>Oda, Yasutaka</creatorcontrib><creatorcontrib>Todani, Masaki</creatorcontrib><creatorcontrib>Kawamura, Yoshikatsu</creatorcontrib><creatorcontrib>Kaneda, Kotaro</creatorcontrib><creatorcontrib>Tsuruta, Ryosuke</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of intensive care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukuda, Shinya</au><au>Miyauchi, Takashi</au><au>Fujita, Motoki</au><au>Oda, Yasutaka</au><au>Todani, Masaki</au><au>Kawamura, Yoshikatsu</au><au>Kaneda, Kotaro</au><au>Tsuruta, Ryosuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for late defecation and its association with the outcomes of critically ill patients: a retrospective observational study</atitle><jtitle>Journal of intensive care</jtitle><addtitle>J Intensive Care</addtitle><date>2016-04-29</date><risdate>2016</risdate><volume>4</volume><issue>33</issue><spage>33</spage><epage>33</epage><pages>33-33</pages><artnum>33</artnum><issn>2052-0492</issn><eissn>2052-0492</eissn><abstract>Late defecation was recently reported to be associated with worse clinical outcomes in critically ill patients. However, more research is needed to examine the causes and clinical significance of late defecation. The objectives of this study were to investigate the risk factors for late defecation and its association with the outcomes of intensive care unit (ICU) patients.
Patients in an ICU for ≥7 days between January and December 2011 were retrospectively assessed. Based on the time between admission and the first defecation, they were assigned to early (<6 days; n = 186) or late (≥6 days; n = 96) defecation groups. Changes in clinical variables between admission and ICU day 7 were assessed to investigate the effects of late defecation. The clinical outcomes were ICU mortality, length of ICU stay, and length of mechanical ventilation.
Late enteral nutrition (odds ratio (OR) 3.42; 95 % confidence interval (CI) 1.88-6.22; P < 0.001), sedatives (OR 3.07; 95 % CI 1.71-5.52; P < 0.001), and surgery (OR 1.86; 95 % CI 1.01-3.42; P = 0.047) were the independent risk factors for late defecation. The median (interquartile) changes in body temperature (0.3 [-0.4 to 1.0] vs 0.7 [0.1 to 1.5] °C; P = 0.004), serum C-reactive protein concentration (1.6 [-0.5 to 6.6] vs 3.5 [0.7 to 8.5] mg/dL; P = 0.035), and Sequential Organ Failure Assessment score (-1 [-2 to 1] vs 0 [-1 to 2]; P = 0.008) between admission and ICU day 7 were significantly greater in the late defecation group than in the early defecation group. ICU stay was significantly longer in the late defecation group (12 [9 to 19] vs 16 [10 to 23] days; P = 0.021), whereas ICU mortality and the length of mechanical ventilation were similar in both groups.
Late enteral nutrition, sedatives, and surgery were independent the risk factors for late defecation in critically ill patients. Late defecation was associated with prolonged ICU stay.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27134753</pmid><doi>10.1186/s40560-016-0156-1</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | Springer Online Journals Complete; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central; Springer Nature OA/Free Journals |
| subjects | Analysis C-reactive protein Defecation Health aspects |
| title | Risk factors for late defecation and its association with the outcomes of critically ill patients: a retrospective observational study |
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