A role for the bacterial GATC methylome in antibiotic stress survival

James Collins and colleagues explore the role of the bacterial epigenome in antibiotic stress survival. They find that Escherichia coli survival under antibiotic pressure is strongly compromised in the absence of adenine methylation at GATC sites, suggesting that targeting adenine methylation might...

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Veröffentlicht in:	Nature genetics 2016-05, Vol.48 (5), p.581-586
Hauptverfasser:	Cohen, Nadia R, Ross, Christian A, Jain, Saloni, Shapiro, Rebecca S, Gutierrez, Arnaud, Belenky, Peter, Li, Hu, Collins, James J
Format:	Artikel
Sprache:	eng
Schlagworte:	42/41 45/22 45/23 45/70 631/1647/514/1948 631/208/176 631/326/1320 631/326/325 64 692/699/255/1318 96/44 Adenine - metabolism Agriculture Animal Genetics and Genomics Antibiotic resistance Antibiotics Bacteria Bioinformatics Biomedicine Cancer Research Cell cycle Cellular proteins Datasets Deoxyribonucleic acid DNA DNA Methylation DNA, Bacterial - metabolism Drug dosages Drug resistance Drug resistance in microorganisms Drug Resistance, Bacterial - genetics E coli Epigenetic inheritance Epigenetics Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Experiments Gene expression Gene Function Genetic aspects Genomes Human Genetics Kinetics letter Mutagenesis Phase transitions Prokaryotes Properties Public health Stress, Physiological Studies Survival
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