Ryk controls remapping of motor cortex during functional recovery after spinal cord injury

Mechanisms underlying partial functional recovery after spinal cord injury are unclear. Conditionally knocking out the reinduced repulsive axon guidance receptor Ryk led to increased corticospinal axon plasticity and functional recovery. Motor cortex reorganized such that the hindlimb cortex control...

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Veröffentlicht in:	Nature neuroscience 2016-05, Vol.19 (5), p.697-705
Hauptverfasser:	Hollis, Edmund R, Ishiko, Nao, Yu, Ting, Lu, Chin-Chun, Haimovich, Ariela, Tolentino, Kristine, Richman, Alisha, Tury, Anna, Wang, Shih-Hsiu, Pessian, Maysam, Jo, Euna, Kolodkin, Alex, Zou, Yimin
Format:	Artikel
Sprache:	eng
Schlagworte:	42/41 45 631/378/1687/1825 631/378/2632/1663 64 64/60 82 82/1 Animal Genetics and Genomics Animals Antibodies, Monoclonal - pharmacology Behavioral Sciences Biological Techniques Biomedicine Brain Mapping Cell receptors Cellular signal transduction Exercise Therapy Female Forelimb - physiology Genetic aspects Mice Mice, Knockout Mice, Transgenic Monoclonal antibodies Motor cortex Motor Cortex - physiology Neurobiology Neuronal Plasticity - physiology Neurosciences Properties Pyramidal Tracts - cytology Pyramidal Tracts - drug effects Rats Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - physiology Recovery of Function - physiology Spinal cord injuries Spinal Cord Injuries - physiopathology Spinal Cord Injuries - therapy
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