MicroRNAs-491-5p suppresses cell proliferation and invasion by inhibiting IGF2BP1 in non-small cell lung cancer

MicroRNAs-491-5p suppresses cell proliferation and invasion by inhibiting IGF2BP1 in non-small cell lung cancer

MicroRNAs-491-5p (miR-491-5p) has been found to involve in tumor initiation and development in several tumors. However, the biological function and underlying molecular mechanism of miR-491-5p in non-small lung cancer (NSCLC) remain unclear. This study was therefore to investigate biological role of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of translational research 2016-01, Vol.8 (2), p.485-495
Hauptverfasser: Gong, Fangchao, Ren, Ping, Zhang, Yan, Jiang, Jindong, Zhang, Hong
Format: Artikel
Sprache:eng
Schlagworte:
Original
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 495
container_issue 2
container_start_page 485
container_title American journal of translational research
container_volume 8
creator Gong, Fangchao
Ren, Ping
Zhang, Yan
Jiang, Jindong
Zhang, Hong
description MicroRNAs-491-5p (miR-491-5p) has been found to involve in tumor initiation and development in several tumors. However, the biological function and underlying molecular mechanism of miR-491-5p in non-small lung cancer (NSCLC) remain unclear. This study was therefore to investigate biological role of and underlying molecular mechanisms of in NSCLC. It was found that miR-491-5p expression was significantly downregulated in NSCLC tissues when compared with corresponding adjacent normal tissues (P
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4846898</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1787935864</sourcerecordid><originalsourceid>FETCH-LOGICAL-p266t-27b2c5a39ab510e64ed88ca415ed5f76019b8a396264c11a5796f1cf1fd99d623</originalsourceid><addsrcrecordid>eNpVkF1LwzAUhosobk7_gvTSm0JPmqTJjTCHm4P5geh1SdN0i7RJTdrB_r2ZTplX5-M953k55yQaA8dZwgDD6VE-ii68_0hTSjhF59EI5UBYhmEc2UctnX19mvoEc0hIF_uh65zyXvlYqqaJO2cbXSsnem1NLEwVa7MVfl-Uu5BvdKl7bdbxcjFHdy8QWrGxJvGtCNvfiGYIshRGKncZndWi8erqECfR-_z-bfaQrJ4Xy9l0lXSI0j5BeYkkERkXJYFUUawqxqTAQFRF6pymwEsWZIoolgCC5JzWIGuoK84rirJJdPvD7YayVZVUpneiKTqnW-F2hRW6-K8YvSnWdltghinjLABuDgBnPwfl-6LVfn-NMMoOvoCc5TwjjOIwen3s9Wfy--XsC7dSetA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1787935864</pqid></control><display><type>article</type><title>MicroRNAs-491-5p suppresses cell proliferation and invasion by inhibiting IGF2BP1 in non-small cell lung cancer</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Gong, Fangchao ; Ren, Ping ; Zhang, Yan ; Jiang, Jindong ; Zhang, Hong</creator><creatorcontrib>Gong, Fangchao ; Ren, Ping ; Zhang, Yan ; Jiang, Jindong ; Zhang, Hong</creatorcontrib><description>MicroRNAs-491-5p (miR-491-5p) has been found to involve in tumor initiation and development in several tumors. However, the biological function and underlying molecular mechanism of miR-491-5p in non-small lung cancer (NSCLC) remain unclear. This study was therefore to investigate biological role of and underlying molecular mechanisms of in NSCLC. It was found that miR-491-5p expression was significantly downregulated in NSCLC tissues when compared with corresponding adjacent normal tissues (P&lt;0.01), and the value was negatively related to advanced and tumor-node-metastasis (TNM) stage and lymph node metastasis (both P&lt;0.01). We also demonstrate that restoration of miR-491-5p suppressed NSCLC cell proliferation by arresting NSCLC cells in the G1/G0 phase and accelerating apoptosis. miR-491-5p also inhibited cell migration and invasion in NSCLC cells. Mechanically, IGF2BP1 was identified as direct targets of miR-491-5p. And IGF2BP1 expression was significantly upregulated, and correlated negative with miR-491-5p expression in NSCLC tissues. In vivo assay showed thatmiR-491-5p suppressed tumor growth in nude model by repressing IGF2BP1 expression. Collectively, miR-491-5p functioned as a tumor suppressor in NSCLC by targeting IGF2BP1. Restoration of miR-491-5p expression may represent a promising therapeutic approach for targeting malignant NSCLC.</description><identifier>ISSN: 1943-8141</identifier><identifier>EISSN: 1943-8141</identifier><identifier>PMID: 27158341</identifier><language>eng</language><publisher>United States: e-Century Publishing Corporation</publisher><subject>Original</subject><ispartof>American journal of translational research, 2016-01, Vol.8 (2), p.485-495</ispartof><rights>AJTR Copyright © 2016 2016</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846898/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846898/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27158341$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gong, Fangchao</creatorcontrib><creatorcontrib>Ren, Ping</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Jiang, Jindong</creatorcontrib><creatorcontrib>Zhang, Hong</creatorcontrib><title>MicroRNAs-491-5p suppresses cell proliferation and invasion by inhibiting IGF2BP1 in non-small cell lung cancer</title><title>American journal of translational research</title><addtitle>Am J Transl Res</addtitle><description>MicroRNAs-491-5p (miR-491-5p) has been found to involve in tumor initiation and development in several tumors. However, the biological function and underlying molecular mechanism of miR-491-5p in non-small lung cancer (NSCLC) remain unclear. This study was therefore to investigate biological role of and underlying molecular mechanisms of in NSCLC. It was found that miR-491-5p expression was significantly downregulated in NSCLC tissues when compared with corresponding adjacent normal tissues (P&lt;0.01), and the value was negatively related to advanced and tumor-node-metastasis (TNM) stage and lymph node metastasis (both P&lt;0.01). We also demonstrate that restoration of miR-491-5p suppressed NSCLC cell proliferation by arresting NSCLC cells in the G1/G0 phase and accelerating apoptosis. miR-491-5p also inhibited cell migration and invasion in NSCLC cells. Mechanically, IGF2BP1 was identified as direct targets of miR-491-5p. And IGF2BP1 expression was significantly upregulated, and correlated negative with miR-491-5p expression in NSCLC tissues. In vivo assay showed thatmiR-491-5p suppressed tumor growth in nude model by repressing IGF2BP1 expression. Collectively, miR-491-5p functioned as a tumor suppressor in NSCLC by targeting IGF2BP1. Restoration of miR-491-5p expression may represent a promising therapeutic approach for targeting malignant NSCLC.</description><subject>Original</subject><issn>1943-8141</issn><issn>1943-8141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNpVkF1LwzAUhosobk7_gvTSm0JPmqTJjTCHm4P5geh1SdN0i7RJTdrB_r2ZTplX5-M953k55yQaA8dZwgDD6VE-ii68_0hTSjhF59EI5UBYhmEc2UctnX19mvoEc0hIF_uh65zyXvlYqqaJO2cbXSsnem1NLEwVa7MVfl-Uu5BvdKl7bdbxcjFHdy8QWrGxJvGtCNvfiGYIshRGKncZndWi8erqECfR-_z-bfaQrJ4Xy9l0lXSI0j5BeYkkERkXJYFUUawqxqTAQFRF6pymwEsWZIoolgCC5JzWIGuoK84rirJJdPvD7YayVZVUpneiKTqnW-F2hRW6-K8YvSnWdltghinjLABuDgBnPwfl-6LVfn-NMMoOvoCc5TwjjOIwen3s9Wfy--XsC7dSetA</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Gong, Fangchao</creator><creator>Ren, Ping</creator><creator>Zhang, Yan</creator><creator>Jiang, Jindong</creator><creator>Zhang, Hong</creator><general>e-Century Publishing Corporation</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>MicroRNAs-491-5p suppresses cell proliferation and invasion by inhibiting IGF2BP1 in non-small cell lung cancer</title><author>Gong, Fangchao ; Ren, Ping ; Zhang, Yan ; Jiang, Jindong ; Zhang, Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-27b2c5a39ab510e64ed88ca415ed5f76019b8a396264c11a5796f1cf1fd99d623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Gong, Fangchao</creatorcontrib><creatorcontrib>Ren, Ping</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Jiang, Jindong</creatorcontrib><creatorcontrib>Zhang, Hong</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of translational research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gong, Fangchao</au><au>Ren, Ping</au><au>Zhang, Yan</au><au>Jiang, Jindong</au><au>Zhang, Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNAs-491-5p suppresses cell proliferation and invasion by inhibiting IGF2BP1 in non-small cell lung cancer</atitle><jtitle>American journal of translational research</jtitle><addtitle>Am J Transl Res</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>8</volume><issue>2</issue><spage>485</spage><epage>495</epage><pages>485-495</pages><issn>1943-8141</issn><eissn>1943-8141</eissn><abstract>MicroRNAs-491-5p (miR-491-5p) has been found to involve in tumor initiation and development in several tumors. However, the biological function and underlying molecular mechanism of miR-491-5p in non-small lung cancer (NSCLC) remain unclear. This study was therefore to investigate biological role of and underlying molecular mechanisms of in NSCLC. It was found that miR-491-5p expression was significantly downregulated in NSCLC tissues when compared with corresponding adjacent normal tissues (P&lt;0.01), and the value was negatively related to advanced and tumor-node-metastasis (TNM) stage and lymph node metastasis (both P&lt;0.01). We also demonstrate that restoration of miR-491-5p suppressed NSCLC cell proliferation by arresting NSCLC cells in the G1/G0 phase and accelerating apoptosis. miR-491-5p also inhibited cell migration and invasion in NSCLC cells. Mechanically, IGF2BP1 was identified as direct targets of miR-491-5p. And IGF2BP1 expression was significantly upregulated, and correlated negative with miR-491-5p expression in NSCLC tissues. In vivo assay showed thatmiR-491-5p suppressed tumor growth in nude model by repressing IGF2BP1 expression. Collectively, miR-491-5p functioned as a tumor suppressor in NSCLC by targeting IGF2BP1. Restoration of miR-491-5p expression may represent a promising therapeutic approach for targeting malignant NSCLC.</abstract><cop>United States</cop><pub>e-Century Publishing Corporation</pub><pmid>27158341</pmid><tpages>11</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1943-8141
ispartof American journal of translational research, 2016-01, Vol.8 (2), p.485-495
issn 1943-8141
1943-8141
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4846898
source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
subjects Original
title MicroRNAs-491-5p suppresses cell proliferation and invasion by inhibiting IGF2BP1 in non-small cell lung cancer
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T22%3A57%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MicroRNAs-491-5p%20suppresses%20cell%20proliferation%20and%20invasion%20by%20inhibiting%20IGF2BP1%20in%20non-small%20cell%20lung%20cancer&rft.jtitle=American%20journal%20of%20translational%20research&rft.au=Gong,%20Fangchao&rft.date=2016-01-01&rft.volume=8&rft.issue=2&rft.spage=485&rft.epage=495&rft.pages=485-495&rft.issn=1943-8141&rft.eissn=1943-8141&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1787935864%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1787935864&rft_id=info:pmid/27158341&rfr_iscdi=true