Differential utilization of binding loop flexibility in T cell receptor ligand selection and cross-reactivity

Complementarity determining region (CDR) loop flexibility has been suggested to play an important role in the selection and binding of ligands by T cell receptors (TCRs) of the cellular immune system. However, questions remain regarding the role of loop motion in TCR binding, and crystallographic st...

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Veröffentlicht in:	Scientific reports 2016-04, Vol.6 (1), p.25070-25070, Article 25070
Hauptverfasser:	Ayres, Cory M., Scott, Daniel R., Corcelli, Steven A., Baker, Brian M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 631/57 Binding Sites Complementarity Complementarity Determining Regions - chemistry Complementarity Determining Regions - metabolism Cross Reactions Cross-reactivity Flexibility Humanities and Social Sciences Immune system Immunity, Cellular Ligands Lymphocytes Lymphocytes T Molecular Dynamics Simulation multidisciplinary Protein Binding Protein Conformation Receptors, Antigen, T-Cell - chemistry Receptors, Antigen, T-Cell - metabolism Science Science (multidisciplinary) T cell receptors
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