Fluorinated methacrylamide chitosan hydrogels enhance collagen synthesis in wound healing through increased oxygen availability

[Display omitted] In this study, methacrylamide chitosan modified with perfluorocarbon chains (MACF) is used as the base material to construct hydrogel dressings for treating dermal wounds. MACF hydrogels saturated with oxygen (+O2) are examined for their ability to deliver and sustain oxygen, degra...

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Veröffentlicht in:	Acta biomaterialia 2016-05, Vol.36, p.164-174
Hauptverfasser:	Patil, Pritam S., Fountas-Davis, Natalie, Huang, He, Michelle Evancho-Chapman, M., Fulton, Judith A., Shriver, Leah P., Leipzig, Nic D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - chemistry Acrylamides - pharmacology Animals Biomaterials Biomedical materials Chitosan Chitosan - chemistry Chitosan - pharmacology Collagen - biosynthesis Fluorocarbon Polymers - chemistry Fluorocarbon Polymers - pharmacology Hydrogels Hydrogels - chemistry Hydrogels - pharmacology Male Metabolomics Methacrylamide Oxygen Oxygen - metabolism Oxygen delivery Perfluorocarbons Rats Rats, Wistar Surgical implants Wound healing Wound Healing - drug effects Wounds, Penetrating - drug therapy Wounds, Penetrating - metabolism
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