Role of inflammatory cells in fibroblast activation

Abstract Although fibrosis is an essential response to acute cardiac tissue injury, prolonged myofibroblast activation and progressive fibrosis lead to further distortion of tissue architecture and worsened cardiac function. Thus, optimal tissue repair following injury requires tight control over my...

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Veröffentlicht in:Journal of molecular and cellular cardiology 2016-04, Vol.93, p.143-148
Hauptverfasser: Hartupee, Justin, Mann, Douglas L
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container_title Journal of molecular and cellular cardiology
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creator Hartupee, Justin
Mann, Douglas L
description Abstract Although fibrosis is an essential response to acute cardiac tissue injury, prolonged myofibroblast activation and progressive fibrosis lead to further distortion of tissue architecture and worsened cardiac function. Thus, optimal tissue repair following injury requires tight control over myofibroblast activation. It is now recognized that inflammation plays a critical role in regulating fibrosis. In this review we will highlight how advances in the field of innate immunity have led to a better understanding of the role of inflammation in cardiovascular disease and, in particular, in the regulation of fibrosis. Specifically, we will discuss how the innate immune system recognizes tissue damage in settings of acute injury and chronic cardiovascular disease. We will also review the role of different cell populations in this response, particularly the unique role of different macrophage subsets and mast cells.
doi_str_mv 10.1016/j.yjmcc.2015.11.016
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subjects Animals
Cardiovascular
Fibroblasts - metabolism
Fibrosis
Humans
Immune System - cytology
Immune System - immunology
Immune System - metabolism
Immunity, Innate
Inflammation
Inflammation - etiology
Inflammation - metabolism
Inflammation - pathology
Innate immunity
Macrophage
Mast cell
Myocarditis - etiology
Myocarditis - metabolism
Myocarditis - pathology
Myocarditis - physiopathology
Myocardium - metabolism
Myocardium - pathology
Myofibroblasts - metabolism
Signal Transduction
title Role of inflammatory cells in fibroblast activation
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