Mental Fatigability and Heart Rate Variability in Mild Cognitive Impairment
Objectives Adaptive physiological stress regulation is rarely studied in mild cognitive impairment (MCI). Here we targeted mental fatigability (MF) as a determinant of altered high frequency heart rate variability (HF-HRV) reactivity in individuals with MCI, and examined frontobasal ganglia circuitr...
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Veröffentlicht in: | The American journal of geriatric psychiatry 2016-05, Vol.24 (5), p.374-378 |
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container_title | The American journal of geriatric psychiatry |
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creator | Lin, Feng, Ph.D Ren, Ping, Ph.D Cotton, Kelly, B.S Porsteinsson, Anton, M.D Mapstone, Mark, Ph.D Heffner, Kathi L., Ph.D |
description | Objectives Adaptive physiological stress regulation is rarely studied in mild cognitive impairment (MCI). Here we targeted mental fatigability (MF) as a determinant of altered high frequency heart rate variability (HF-HRV) reactivity in individuals with MCI, and examined frontobasal ganglia circuitry as a neural basis supporting the link between MF and HF-HRV reactivity. Methods We measured mental fatigability and HF-HRV during a 60-minute cognitive stress protocol in 19 individuals with MCI. HF-HRV responses were modeled using a quadratic equation. Resting state functional connectivity of intra- and inter-network frontobasal ganglia circuitry was assessed using blood-oxygen-level-dependent magnetic resonance imaging among seven of the participants. Results Lower MF was associated with faster and greater rebound in U-shape HF-HRV reactivity, which linked to a stronger connectivity between right middle frontal gyrus and left putamen. Conclusions Results suggest that MF may contribute to abnormal physiological stress regulation in MCI, and fronto basal ganglia circuitry may support the link. |
doi_str_mv | 10.1016/j.jagp.2015.12.012 |
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Here we targeted mental fatigability (MF) as a determinant of altered high frequency heart rate variability (HF-HRV) reactivity in individuals with MCI, and examined frontobasal ganglia circuitry as a neural basis supporting the link between MF and HF-HRV reactivity. Methods We measured mental fatigability and HF-HRV during a 60-minute cognitive stress protocol in 19 individuals with MCI. HF-HRV responses were modeled using a quadratic equation. Resting state functional connectivity of intra- and inter-network frontobasal ganglia circuitry was assessed using blood-oxygen-level-dependent magnetic resonance imaging among seven of the participants. Results Lower MF was associated with faster and greater rebound in U-shape HF-HRV reactivity, which linked to a stronger connectivity between right middle frontal gyrus and left putamen. Conclusions Results suggest that MF may contribute to abnormal physiological stress regulation in MCI, and fronto basal ganglia circuitry may support the link.</description><identifier>ISSN: 1064-7481</identifier><identifier>EISSN: 1545-7214</identifier><identifier>DOI: 10.1016/j.jagp.2015.12.012</identifier><identifier>PMID: 26905050</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Aged ; cardiovascular reactivity ; Cognitive Dysfunction - complications ; Cognitive Dysfunction - physiopathology ; Cognitive Dysfunction - psychology ; Female ; frontobasal ganglia circuitry ; Heart Rate - physiology ; Humans ; Internal Medicine ; Magnetic Resonance Imaging ; Male ; mental fatigability ; Mental Fatigue - complications ; Mental Fatigue - physiopathology ; Mental Fatigue - psychology ; mild cognitive impairment ; Neural Pathways - physiopathology ; Neuroimaging ; physiological stress regulation ; Prefrontal Cortex - physiopathology ; Putamen - physiopathology ; Stress, Psychological - complications ; Stress, Psychological - psychology</subject><ispartof>The American journal of geriatric psychiatry, 2016-05, Vol.24 (5), p.374-378</ispartof><rights>American Association for Geriatric Psychiatry</rights><rights>2016 American Association for Geriatric Psychiatry</rights><rights>Copyright © 2016 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-d4def3da501e353844d634ced841db6919220d0846b3e991c03a0b0a5364dbee3</citedby><cites>FETCH-LOGICAL-c510t-d4def3da501e353844d634ced841db6919220d0846b3e991c03a0b0a5364dbee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26905050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Feng, Ph.D</creatorcontrib><creatorcontrib>Ren, Ping, Ph.D</creatorcontrib><creatorcontrib>Cotton, Kelly, B.S</creatorcontrib><creatorcontrib>Porsteinsson, Anton, M.D</creatorcontrib><creatorcontrib>Mapstone, Mark, Ph.D</creatorcontrib><creatorcontrib>Heffner, Kathi L., Ph.D</creatorcontrib><title>Mental Fatigability and Heart Rate Variability in Mild Cognitive Impairment</title><title>The American journal of geriatric psychiatry</title><addtitle>Am J Geriatr Psychiatry</addtitle><description>Objectives Adaptive physiological stress regulation is rarely studied in mild cognitive impairment (MCI). Here we targeted mental fatigability (MF) as a determinant of altered high frequency heart rate variability (HF-HRV) reactivity in individuals with MCI, and examined frontobasal ganglia circuitry as a neural basis supporting the link between MF and HF-HRV reactivity. Methods We measured mental fatigability and HF-HRV during a 60-minute cognitive stress protocol in 19 individuals with MCI. HF-HRV responses were modeled using a quadratic equation. Resting state functional connectivity of intra- and inter-network frontobasal ganglia circuitry was assessed using blood-oxygen-level-dependent magnetic resonance imaging among seven of the participants. Results Lower MF was associated with faster and greater rebound in U-shape HF-HRV reactivity, which linked to a stronger connectivity between right middle frontal gyrus and left putamen. Conclusions Results suggest that MF may contribute to abnormal physiological stress regulation in MCI, and fronto basal ganglia circuitry may support the link.</description><subject>Aged</subject><subject>cardiovascular reactivity</subject><subject>Cognitive Dysfunction - complications</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Female</subject><subject>frontobasal ganglia circuitry</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>mental fatigability</subject><subject>Mental Fatigue - complications</subject><subject>Mental Fatigue - physiopathology</subject><subject>Mental Fatigue - psychology</subject><subject>mild cognitive impairment</subject><subject>Neural Pathways - physiopathology</subject><subject>Neuroimaging</subject><subject>physiological stress regulation</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Putamen - physiopathology</subject><subject>Stress, Psychological - complications</subject><subject>Stress, Psychological - psychology</subject><issn>1064-7481</issn><issn>1545-7214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Ul2L1DAULaK4H_oHfJA--tLuvUmaaUEWZHDdxV0Ev15DmtwZb-20Y9IZmH9vyuwu6oPkIYF7zrnhnJNlrxBKBNQXXdnZ9bYUgFWJogQUT7JTrFRVLASqp-kNWhULVeNJdhZjBwC60ep5diJ0A1U6p9nHOxom2-dXduK1bbnn6ZDbwefXZMOUf7YT5d9t4IcRD_kd9z5fjuuBJ95TfrPZWg6bJPMie7ayfaSX9_d59u3q_dfldXH76cPN8t1t4SqEqfDK00p6WwGSrGStlNdSOfK1Qt_qBhshwEOtdCupadCBtNCCraRWviWS59nlUXe7azfkXVodbG-2gTc2HMxo2fw9GfiHWY97o5Km0k0SeHMvEMZfO4qT2XB01Pd2oHEXDS5qlWwDMUPFEerCGGOg1eMaBDOnYDozp2DmFAwKk1JIpNd_fvCR8mB7Arw9AijZtGcKJjqmIXnAgdxk_Mj_17_8h-56HtjZ_icdKHbjLgwpAIMmJoL5MvdgrgHqVAGQtfwNr2uuEA</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Lin, Feng, Ph.D</creator><creator>Ren, Ping, Ph.D</creator><creator>Cotton, Kelly, B.S</creator><creator>Porsteinsson, Anton, M.D</creator><creator>Mapstone, Mark, Ph.D</creator><creator>Heffner, Kathi L., Ph.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160501</creationdate><title>Mental Fatigability and Heart Rate Variability in Mild Cognitive Impairment</title><author>Lin, Feng, Ph.D ; Ren, Ping, Ph.D ; Cotton, Kelly, B.S ; Porsteinsson, Anton, M.D ; Mapstone, Mark, Ph.D ; Heffner, Kathi L., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-d4def3da501e353844d634ced841db6919220d0846b3e991c03a0b0a5364dbee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>cardiovascular reactivity</topic><topic>Cognitive Dysfunction - complications</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>Cognitive Dysfunction - psychology</topic><topic>Female</topic><topic>frontobasal ganglia circuitry</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>mental fatigability</topic><topic>Mental Fatigue - complications</topic><topic>Mental Fatigue - physiopathology</topic><topic>Mental Fatigue - psychology</topic><topic>mild cognitive impairment</topic><topic>Neural Pathways - physiopathology</topic><topic>Neuroimaging</topic><topic>physiological stress regulation</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Putamen - physiopathology</topic><topic>Stress, Psychological - complications</topic><topic>Stress, Psychological - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Feng, Ph.D</creatorcontrib><creatorcontrib>Ren, Ping, Ph.D</creatorcontrib><creatorcontrib>Cotton, Kelly, B.S</creatorcontrib><creatorcontrib>Porsteinsson, Anton, M.D</creatorcontrib><creatorcontrib>Mapstone, Mark, Ph.D</creatorcontrib><creatorcontrib>Heffner, Kathi L., Ph.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Feng, Ph.D</au><au>Ren, Ping, Ph.D</au><au>Cotton, Kelly, B.S</au><au>Porsteinsson, Anton, M.D</au><au>Mapstone, Mark, Ph.D</au><au>Heffner, Kathi L., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mental Fatigability and Heart Rate Variability in Mild Cognitive Impairment</atitle><jtitle>The American journal of geriatric psychiatry</jtitle><addtitle>Am J Geriatr Psychiatry</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>24</volume><issue>5</issue><spage>374</spage><epage>378</epage><pages>374-378</pages><issn>1064-7481</issn><eissn>1545-7214</eissn><abstract>Objectives Adaptive physiological stress regulation is rarely studied in mild cognitive impairment (MCI). Here we targeted mental fatigability (MF) as a determinant of altered high frequency heart rate variability (HF-HRV) reactivity in individuals with MCI, and examined frontobasal ganglia circuitry as a neural basis supporting the link between MF and HF-HRV reactivity. Methods We measured mental fatigability and HF-HRV during a 60-minute cognitive stress protocol in 19 individuals with MCI. HF-HRV responses were modeled using a quadratic equation. Resting state functional connectivity of intra- and inter-network frontobasal ganglia circuitry was assessed using blood-oxygen-level-dependent magnetic resonance imaging among seven of the participants. Results Lower MF was associated with faster and greater rebound in U-shape HF-HRV reactivity, which linked to a stronger connectivity between right middle frontal gyrus and left putamen. Conclusions Results suggest that MF may contribute to abnormal physiological stress regulation in MCI, and fronto basal ganglia circuitry may support the link.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>26905050</pmid><doi>10.1016/j.jagp.2015.12.012</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aged cardiovascular reactivity Cognitive Dysfunction - complications Cognitive Dysfunction - physiopathology Cognitive Dysfunction - psychology Female frontobasal ganglia circuitry Heart Rate - physiology Humans Internal Medicine Magnetic Resonance Imaging Male mental fatigability Mental Fatigue - complications Mental Fatigue - physiopathology Mental Fatigue - psychology mild cognitive impairment Neural Pathways - physiopathology Neuroimaging physiological stress regulation Prefrontal Cortex - physiopathology Putamen - physiopathology Stress, Psychological - complications Stress, Psychological - psychology |
title | Mental Fatigability and Heart Rate Variability in Mild Cognitive Impairment |
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