Mental Fatigability and Heart Rate Variability in Mild Cognitive Impairment

Objectives Adaptive physiological stress regulation is rarely studied in mild cognitive impairment (MCI). Here we targeted mental fatigability (MF) as a determinant of altered high frequency heart rate variability (HF-HRV) reactivity in individuals with MCI, and examined frontobasal ganglia circuitr...

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Veröffentlicht in:The American journal of geriatric psychiatry 2016-05, Vol.24 (5), p.374-378
Hauptverfasser: Lin, Feng, Ph.D, Ren, Ping, Ph.D, Cotton, Kelly, B.S, Porsteinsson, Anton, M.D, Mapstone, Mark, Ph.D, Heffner, Kathi L., Ph.D
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container_end_page 378
container_issue 5
container_start_page 374
container_title The American journal of geriatric psychiatry
container_volume 24
creator Lin, Feng, Ph.D
Ren, Ping, Ph.D
Cotton, Kelly, B.S
Porsteinsson, Anton, M.D
Mapstone, Mark, Ph.D
Heffner, Kathi L., Ph.D
description Objectives Adaptive physiological stress regulation is rarely studied in mild cognitive impairment (MCI). Here we targeted mental fatigability (MF) as a determinant of altered high frequency heart rate variability (HF-HRV) reactivity in individuals with MCI, and examined frontobasal ganglia circuitry as a neural basis supporting the link between MF and HF-HRV reactivity. Methods We measured mental fatigability and HF-HRV during a 60-minute cognitive stress protocol in 19 individuals with MCI. HF-HRV responses were modeled using a quadratic equation. Resting state functional connectivity of intra- and inter-network frontobasal ganglia circuitry was assessed using blood-oxygen-level-dependent magnetic resonance imaging among seven of the participants. Results Lower MF was associated with faster and greater rebound in U-shape HF-HRV reactivity, which linked to a stronger connectivity between right middle frontal gyrus and left putamen. Conclusions Results suggest that MF may contribute to abnormal physiological stress regulation in MCI, and fronto basal ganglia circuitry may support the link.
doi_str_mv 10.1016/j.jagp.2015.12.012
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Here we targeted mental fatigability (MF) as a determinant of altered high frequency heart rate variability (HF-HRV) reactivity in individuals with MCI, and examined frontobasal ganglia circuitry as a neural basis supporting the link between MF and HF-HRV reactivity. Methods We measured mental fatigability and HF-HRV during a 60-minute cognitive stress protocol in 19 individuals with MCI. HF-HRV responses were modeled using a quadratic equation. Resting state functional connectivity of intra- and inter-network frontobasal ganglia circuitry was assessed using blood-oxygen-level-dependent magnetic resonance imaging among seven of the participants. Results Lower MF was associated with faster and greater rebound in U-shape HF-HRV reactivity, which linked to a stronger connectivity between right middle frontal gyrus and left putamen. Conclusions Results suggest that MF may contribute to abnormal physiological stress regulation in MCI, and fronto basal ganglia circuitry may support the link.</description><identifier>ISSN: 1064-7481</identifier><identifier>EISSN: 1545-7214</identifier><identifier>DOI: 10.1016/j.jagp.2015.12.012</identifier><identifier>PMID: 26905050</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Aged ; cardiovascular reactivity ; Cognitive Dysfunction - complications ; Cognitive Dysfunction - physiopathology ; Cognitive Dysfunction - psychology ; Female ; frontobasal ganglia circuitry ; Heart Rate - physiology ; Humans ; Internal Medicine ; Magnetic Resonance Imaging ; Male ; mental fatigability ; Mental Fatigue - complications ; Mental Fatigue - physiopathology ; Mental Fatigue - psychology ; mild cognitive impairment ; Neural Pathways - physiopathology ; Neuroimaging ; physiological stress regulation ; Prefrontal Cortex - physiopathology ; Putamen - physiopathology ; Stress, Psychological - complications ; Stress, Psychological - psychology</subject><ispartof>The American journal of geriatric psychiatry, 2016-05, Vol.24 (5), p.374-378</ispartof><rights>American Association for Geriatric Psychiatry</rights><rights>2016 American Association for Geriatric Psychiatry</rights><rights>Copyright © 2016 American Association for Geriatric Psychiatry. Published by Elsevier Inc. 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Here we targeted mental fatigability (MF) as a determinant of altered high frequency heart rate variability (HF-HRV) reactivity in individuals with MCI, and examined frontobasal ganglia circuitry as a neural basis supporting the link between MF and HF-HRV reactivity. Methods We measured mental fatigability and HF-HRV during a 60-minute cognitive stress protocol in 19 individuals with MCI. HF-HRV responses were modeled using a quadratic equation. Resting state functional connectivity of intra- and inter-network frontobasal ganglia circuitry was assessed using blood-oxygen-level-dependent magnetic resonance imaging among seven of the participants. Results Lower MF was associated with faster and greater rebound in U-shape HF-HRV reactivity, which linked to a stronger connectivity between right middle frontal gyrus and left putamen. 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Here we targeted mental fatigability (MF) as a determinant of altered high frequency heart rate variability (HF-HRV) reactivity in individuals with MCI, and examined frontobasal ganglia circuitry as a neural basis supporting the link between MF and HF-HRV reactivity. Methods We measured mental fatigability and HF-HRV during a 60-minute cognitive stress protocol in 19 individuals with MCI. HF-HRV responses were modeled using a quadratic equation. Resting state functional connectivity of intra- and inter-network frontobasal ganglia circuitry was assessed using blood-oxygen-level-dependent magnetic resonance imaging among seven of the participants. Results Lower MF was associated with faster and greater rebound in U-shape HF-HRV reactivity, which linked to a stronger connectivity between right middle frontal gyrus and left putamen. 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subjects Aged
cardiovascular reactivity
Cognitive Dysfunction - complications
Cognitive Dysfunction - physiopathology
Cognitive Dysfunction - psychology
Female
frontobasal ganglia circuitry
Heart Rate - physiology
Humans
Internal Medicine
Magnetic Resonance Imaging
Male
mental fatigability
Mental Fatigue - complications
Mental Fatigue - physiopathology
Mental Fatigue - psychology
mild cognitive impairment
Neural Pathways - physiopathology
Neuroimaging
physiological stress regulation
Prefrontal Cortex - physiopathology
Putamen - physiopathology
Stress, Psychological - complications
Stress, Psychological - psychology
title Mental Fatigability and Heart Rate Variability in Mild Cognitive Impairment
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