Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α

The neuromuscular junction (NMJ) exhibits high morphological and functional plasticity. In the mature muscle, the relative levels of physical activity are the major determinants of NMJ function. Classically, motor neuron-mediated activation patterns of skeletal muscle have been thought of as the maj...

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Veröffentlicht in:	Nature communications 2014-04, Vol.5 (1), p.3569-3569, Article 3569
Hauptverfasser:	Arnold, Anne-Sophie, Gill, Jonathan, Christe, Martine, Ruiz, Rocío, McGuirk, Shawn, St-Pierre, Julie, Tabares, Lucía, Handschin, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 38/77 631/378/2632/1694 631/443 64/60 692/698/1671/1668/1973 82/80 Adaptation, Physiological Animals Humanities and Social Sciences Mice Mice, Transgenic multidisciplinary Muscle Contraction Muscle, Skeletal - anatomy & histology Muscle, Skeletal - metabolism Neuromuscular Junction - anatomy & histology Neuromuscular Junction - physiology Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Science Science (multidisciplinary) Transcription Factors - genetics Transcription Factors - metabolism
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