Evidence for AKT-independent regulation of FOXO1 and FOXO3 in haematopoietic stem and progenitor cells

Transcription factors FOXOs (1, 3, 4) are essential for the maintenance of haematopoietic stem cells. FOXOs are evolutionary conserved substrates of the AKT serine threonine protein kinase that are also phosphorylated by several kinases other than AKT. Specifically, phosphorylation by AKT is known t...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2016-03, Vol.15 (6), p.861-867
Hauptverfasser:	Liang, Raymond, Rimmelé, Pauline, Bigarella, Carolina L, Yalcin, Safak, Ghaffari, Saghi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Cell Nucleus - metabolism Chromones - pharmacology Cytosol - metabolism Forkhead Box Protein O1 - genetics Forkhead Box Protein O1 - metabolism Forkhead Box Protein O3 - genetics Forkhead Box Protein O3 - metabolism Gene Expression Regulation Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Mice Mice, Knockout Morpholines - pharmacology Phosphorylation Primary Cell Culture Protein Transport Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Sirtuin 1 - deficiency Sirtuin 1 - genetics
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