Early Molecular Events in the Induction Phase of Contact Sensitivity

To assess changes in epidermis-derived cytokine mRNA levels early in the afferent phase of allergic contact sensitivity, total epidermal mRNA was analyzed at various times after painting skin with haptens. We used a sensitive reverse transcriptase-polymerase chain reaction technique to quantitativel...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-02, Vol.89 (4), p.1398-1402
Hauptverfasser:	Enk, Alexander H., Katz, Stephen I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens - immunology Allergies Animals Antibodies, Monoclonal Base Sequence Biological and medical sciences Chemokine CXCL10 Chemokine CXCL2 Chemokines, CXC Contact dermatitis Cytokines Cytokines - biosynthesis Cytokines - genetics Dermatitis, Contact - physiopathology Epidermal cells Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Granulocyte-Macrophage Colony-Stimulating Factor - genetics Haptens Haptens - immunology Immediate hypersensitivity. Allergy. Anaphylaxis, etc Immune Tolerance Immunity (Disease) Immunobiology Interferon-gamma - genetics Interleukin-1 - analysis Keratinocytes Lymphocyte Depletion Medical research Messenger RNA Mice Mice, Inbred BALB C Molecular Sequence Data Monokines - genetics Polymerase Chain Reaction Reaction mechanisms, antibodies, chemical mediators Ribonucleic acid RNA RNA, Messenger - genetics Signal detection Skin Skin - physiopathology T lymphocytes Time Factors
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