Detection of IFN-γ Secretion by T Cells Collected Before and After Successful Treatment of Early Lyme Disease

Background. Current serodiagnostics for Lyme disease lack sensitivity during early disease, and cannot determine treatment response. We evaluated an assay based on QuantiFERON technology utilizing peptide antigens derived from Borrelia burgdorferi to stimulate interferon-gamma (IFN-γ) release as an...

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Veröffentlicht in:	Clinical infectious diseases 2016-05, Vol.62 (10), p.1235-1241
Hauptverfasser:	Callister, Steven M., Jobe, Dean A., Stuparic-Stancic, Aleksandra, Miyamasu, Misato, Boyle, Jeff, Dattwyler, Raymond J., Arnaboldi, Paul M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged and Commentaries Anti-Bacterial Agents - therapeutic use Antibodies, Bacterial - blood ARTICLES AND COMMENTARIES Borrelia burgdorferi - immunology Doxycycline - therapeutic use Female Humans Interferon-gamma - blood Interferon-gamma - immunology Interferon-gamma - metabolism Interferon-gamma - secretion Interferon-gamma Release Tests - methods Lyme Disease - diagnosis Lyme Disease - drug therapy Lyme Disease - epidemiology Lyme Disease - immunology Male Middle Aged Serologic Tests T-Lymphocytes - immunology Young Adult
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