DNA Triplet Repeat Expansion and Mismatch Repair

DNA mismatch repair is a conserved antimutagenic pathway that maintains genomic stability through rectification of DNA replication errors and attenuation of chromosomal rearrangements. Paradoxically, mutagenic action of mismatch repair has been implicated as a cause of triplet repeat expansions that...

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Veröffentlicht in:	Annual review of biochemistry 2015-01, Vol.84 (1), p.199-226
Hauptverfasser:	Iyer, Ravi R, Pluciennik, Anna, Napierala, Marek, Wells, Robert D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Biochemistry Chromatin - metabolism Chromosomes Deoxyribonucleic acid DNA DNA Mismatch Repair DNA repair Dystrophy Escherichia coli Experiments Gene expression Genomic Instability Genomics hereditary neurological diseases Histones - metabolism Humans Nervous System Diseases - genetics Nervous System Diseases - metabolism Neurological disorders non-B-DNA structures Nucleic Acid Conformation repeat expansion diseases Trinucleotide Repeat Expansion triplet repeats
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