The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome

Human fetuses with Down syndrome demonstrate abnormal brain growth and reduced neurogenesis. Despite the prenatal onset of the phenotype, most therapeutic trials have been conducted in adults. Here, we present evidence for fetal brain molecular and neonatal behavioral alterations in the Ts1Cje mouse...

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Veröffentlicht in:	American journal of medical genetics. Part A 2015-09, Vol.167A (9), p.1993-2008
Hauptverfasser:	Guedj, Faycal, Pennings, Jeroen L. A., Ferres, Millie A., Graham, Leah C., Wick, Heather C., Miczek, Klaus A., Slonim, Donna K., Bianchi, Diana W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Disease Models, Animal Down syndrome Down Syndrome - genetics Down-Regulation - genetics embryonic brain Female Fetus - metabolism gene expression Gene Expression Profiling - methods genotype/phenotype correlation Humans Male Mice Mice, Inbred C57BL neonatal behavior Neurogenesis - genetics Phenotype Pregnancy systems biology Transcriptome - genetics Up-Regulation - genetics
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