Circadian System and Glucose Metabolism: Implications for Physiology and Disease

The circadian system serves one of the most fundamental properties present in nearly all organisms: it generates 24-h rhythms in behavioral and physiological processes and enables anticipating and adapting to daily environmental changes. Recent studies indicate that the circadian system is important...

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Veröffentlicht in:Trends in endocrinology and metabolism 2016-05, Vol.27 (5), p.282-293
Hauptverfasser: Qian, Jingyi, Scheer, Frank A.J.L
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description The circadian system serves one of the most fundamental properties present in nearly all organisms: it generates 24-h rhythms in behavioral and physiological processes and enables anticipating and adapting to daily environmental changes. Recent studies indicate that the circadian system is important in regulating the daily rhythm in glucose metabolism. Disturbance of this circadian control or of its coordination relative to the environmental/behavioral cycle, such as in shift work, eating late, or due to genetic changes, results in disturbed glucose control and increased type 2 diabetes risk. Therefore, an in-depth understanding of the mechanisms underlying glucose regulation by the circadian system and its disturbance may help in the development of therapeutic interventions against the deleterious health consequences of circadian disruption.
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Animals
Circadian Rhythm - genetics
Circadian Rhythm - physiology
circadian rhythms
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - physiopathology
Endocrinology & Metabolism
food timing
Glucose - metabolism
Humans
melatonin
Melatonin - metabolism
sleep
Sleep - genetics
Sleep - physiology
type 2 diabetes
title Circadian System and Glucose Metabolism: Implications for Physiology and Disease
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