Synthesis and pharmacological evaluation of mono-arylimidamides as antileishmanial agents

[Display omitted] Arylimidamide (AIA) compounds containing two pyridylimidamide terminal groups (bis-AIAs) possess outstanding in vitro antileishmanial activity, and the frontrunner bis-AIA DB766 (2,5-bis[2-(2-isopropoxy)-4-(2-pyridylimino)aminophenyl]furan) is active in visceral leishmaniasis model...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2016-05, Vol.26 (10), p.2551-2556
Hauptverfasser:	Zhu, Xiaohua, Farahat, Abdelbasset A., Mattamana, Meena, Joice, April, Pandharkar, Trupti, Holt, Elizabeth, Banerjee, Moloy, Gragg, Jamie L., Hu, Laixing, Kumar, Arvind, Yang, Sihyung, Wang, Michael Zhuo, Boykin, David W., Werbovetz, Karl A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antiprotozoal Agents - chemical synthesis Antiprotozoal Agents - chemistry Antiprotozoal Agents - pharmacology Arylimidamide Chemistry Techniques, Synthetic DB766 Drug discovery Drug Evaluation, Preclinical - methods Furans - chemistry Inhibitory Concentration 50 Leishmania donovani - drug effects Leishmania donovani - pathogenicity Leishmania mexicana - drug effects Leishmania mexicana - pathogenicity Leishmaniasis Leishmaniasis, Visceral - drug therapy Leishmaniasis, Visceral - parasitology Macrophages - drug effects Macrophages - parasitology Mice, Inbred BALB C Parasitemia - drug therapy Parasitemia - parasitology Structure-Activity Relationship
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