Inhibition of Notch Signaling During Mouse Incisor Renewal Leads to Enamel Defects

ABSTRACT The continuously growing rodent incisor is an emerging model for the study of renewal of mineralized tissues by adult stem cells. Although the Bmp, Fgf, Shh, and Wnt pathways have been studied in this organ previously, relatively little is known about the role of Notch signaling during inci...

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Veröffentlicht in:	Journal of bone and mineral research 2016-01, Vol.31 (1), p.152-162
Hauptverfasser:	Jheon, Andrew H, Prochazkova, Michaela, Meng, Bo, Wen, Timothy, Lim, Young‐Jun, Naveau, Adrien, Espinoza, Ruben, Cox, Timothy C, Sone, Eli D, Ganss, Bernhard, Siebel, Christian W, Klein, Ophir D
Format:	Artikel
Sprache:	eng
Schlagworte:	AMELOBLAST Ameloblasts - metabolism Ameloblasts - pathology AMELOGENESIS Animals Dental Enamel - metabolism Dental Enamel - pathology Desmosomes - metabolism Desmosomes - pathology Incisor - metabolism Incisor - pathology JAG Mice NOTCH Receptors, Notch Signal Transduction STRATUM INTERMEDIUM TOOTH DEVELOPMENT Tooth Diseases
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