Increased APRIL Expression Induces IgA1 Aberrant Glycosylation in IgA Nephropathy

Aberrant glycosylated IgA1 molecules, mainly galactose-deficient IgA1 (Gd-IgA1), are important causal factors in IgA nephropathy; however, the underlying mechanism for the production of aberrantly glycosylated IgA1 is unknown. A recent genome-wide association study identified a novel IgAN susceptibi...

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Veröffentlicht in:	Medicine (Baltimore) 2016-03, Vol.95 (11), p.e3099-e3099
Hauptverfasser:	Zhai, Ya-Ling, Zhu, Li, Shi, Su-Fang, Liu, Li-Jun, Lv, Ji-Cheng, Zhang, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult B-Cell Maturation Antigen - metabolism B-Lymphocytes - secretion Female Glomerulonephritis, IGA - blood Glycosylation Humans Immunoglobulin A - metabolism Male Middle Aged Observational Study Transmembrane Activator and CAML Interactor Protein - metabolism Tumor Necrosis Factor Ligand Superfamily Member 13 - blood Up-Regulation Young Adult
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