Hyaluronan-Itaconic Acid-Glutaraldehyde Films for Biomedical Applications: Preliminary Studies

Hyaluronan-Itaconic Acid-Glutaraldehyde Films for Biomedical Applications: Preliminary Studies

New hyaluronic acid-itaconic acid films were synthesized as potential materials with biomedical applications. In this work, we explored the homogeneous cross-linking reactions of hyaluronic acid using glutaraldehyde in the presence of itaconic acid and triacetin as plasticizers. Biomechanical proper...

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Veröffentlicht in:Scientia pharmaceutica 2016-01, Vol.84 (1), p.61-72
Hauptverfasser: Calles, Javier Adrián, Ressia, Jorge Aníbal, Llabot, Juan Manuel, Vallés, Enrique Marcelo, Palma, Santiago Daniel
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container_issue 1
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container_title Scientia pharmaceutica
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creator Calles, Javier Adrián
Ressia, Jorge Aníbal
Llabot, Juan Manuel
Vallés, Enrique Marcelo
Palma, Santiago Daniel
description New hyaluronic acid-itaconic acid films were synthesized as potential materials with biomedical applications. In this work, we explored the homogeneous cross-linking reactions of hyaluronic acid using glutaraldehyde in the presence of itaconic acid and triacetin as plasticizers. Biomechanical properties were assessed in terms of stability by measuring swelling in aqueous environments, investigating wettability using contact angle tests, and evaluating bioadhesive performance. The ductility of the materials was evaluated through stress-strain measurements and the morphology was explored by scanning electron microscopy. The results show that the incorporation of itaconic acid improved most of the desirable properties, increasing adhesiveness and reducing wettability and swelling. The use of triacetin enhanced the strength, bioadhesiveness, and ductility of the material.
doi_str_mv 10.3797/scipharm.1504-17
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title Hyaluronan-Itaconic Acid-Glutaraldehyde Films for Biomedical Applications: Preliminary Studies
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