A bioavailable cathepsin S nitrile inhibitor abrogates tumor development

Cathepsin S has been implicated in a variety of malignancies with genetic ablation studies demonstrating a key role in tumor invasion and neo-angiogenesis. Thus, the application of cathepsin S inhibitors may have clinical utility in the treatment of cancer. In this investigation, we applied a cell-p...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cancer 2016-04, Vol.15 (29), p.29, Article 29
Hauptverfasser:	Wilkinson, Richard D A, Young, Andrew, Burden, Roberta E, Williams, Rich, Scott, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biological Availability Carcinogenesis - drug effects Carcinogenesis - genetics Carcinogenesis - pathology Care and treatment Cathepsins Cathepsins - antagonists & inhibitors Cathepsins - metabolism Cellular signal transduction Development and progression Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Influence Intracellular Space - metabolism MCF-7 Cells Mice, Inbred BALB C Mice, Inbred C57BL Neoplasm Invasiveness Neovascularization, Physiologic - drug effects Nitriles - chemistry Nitriles - pharmacology Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Proteolysis - drug effects Recombinant Proteins - metabolism Tumors Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!