Structural basis for PHDVC5HCHNSD1-C2HRNizp1 interaction: implications for Sotos syndrome

Sotos syndrome is an overgrowth syndrome caused by mutations within the functional domains ofNSD1 gene coding for NSD1, a multidomain protein regulating chromatin structure and gene expression. In particular, PHDVC5HCHNSD1 tandem domain, composed by a classical (PHDV) and an atypical (C5HCH) plant h...

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Veröffentlicht in:	Nucleic acids research 2016-04, Vol.44 (7), p.3448-3463
Hauptverfasser:	Berardi, Andrea, Quilici, Giacomo, Spiliotopoulos, Dimitrios, Corral-Rodriguez, Maria Angeles, Martin-Garcia, Fernando, Degano, Massimo, Tonon, Giovanni, Ghitti, Michela, Musco, Giovanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Histones - metabolism Humans Mice Models, Molecular Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Point Mutation Protein Structure, Tertiary Sotos Syndrome - genetics Structural Biology
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