Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability

DNA double-strand breaks (DSBs) and their repair can cause extensive epigenetic changes. As a result, DSBs have been proposed to promote transcriptional and, ultimately, physiological dysfunction via both cell-intrinsic and cell-non-autonomous pathways. Studying the consequences of DSBs in higher or...

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Veröffentlicht in:	Nucleic acids research 2016-04, Vol.44 (7), p.e64-e64
Hauptverfasser:	Kim, Jeongkyu, Sturgill, David, Tran, Andy D, Sinclair, David A, Oberdoerffer, Philipp
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured DNA Breaks, Double-Stranded Endodeoxyribonucleases Genetic Loci Methods Online Mice Mice, Transgenic Signal Transduction Transcriptome
Online-Zugang:	Volltext
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