Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect

The biological effect of an inorganic particle (i.e., silica) can be associated with a disruption in cell iron homeostasis. Organic compounds included in particles originating from combustion processes can also complex sources of host cell iron to disrupt metal homeostasis. We tested the postulate t...

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Veröffentlicht in:	Chemical research in toxicology 2015-11, Vol.28 (11), p.2104-2111
Hauptverfasser:	Ghio, Andrew J, Soukup, Joleen M, Dailey, Lisa A, Tong, Haiyan, Kesic, Matthew J, Budinger, G. R. Scott, Mutlu, Gökhan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Cell Nucleus - metabolism Humans Humic Substances Interleukin-6 - metabolism Interleukin-8 - metabolism Iron - metabolism Mitochondria - metabolism Mitogen-Activated Protein Kinases - metabolism Smoke - adverse effects Transcription Factors - genetics Wood
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