Dirofilaria repens: emergence of autochthonous human infections in the Czech Republic (case reports)
Human dirofilariasis is a zoonotic infection that continues to spread to previously unaffected areas of Europe. In the South Moravian Region of the Czech Republic (CR), imported as well as autochthonous canine infections were recorded in the last decade, and parasite DNA was detected in mosquitoes o...
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| Veröffentlicht in: | BMC infectious diseases 2016-04, Vol.16 (165), p.171-171, Article 171 |
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| creator | MatAjA¯, Jana Chanova, Marta Mitkova, Barbora Hrazdilova, KristA1 KolaAova, LibuA e |
| description | Human dirofilariasis is a zoonotic infection that continues to spread to previously unaffected areas of Europe. In the South Moravian Region of the Czech Republic (CR), imported as well as autochthonous canine infections were recorded in the last decade, and parasite DNA was detected in mosquitoes of Aedes vexans. In the present paper, human Dirofilaria infections are reported from the country for the first time.
The samples from five patients with suspected tissue helminthiases were investigated. In particular cases, nematodes were isolated from various tissues including skin of lower leg, soft tissues of finger, subcutaneous tissue of hypogastrium, lymph node and peritoneum. The diagnosis was based on light microscopic morphology and/or DNA analysis of the worms. In addition, ELISA examination of patients' sera for anti-filaria IgG antibodies was performed.
In the CR, five cases of human dirofilariasis caused by Dirofilaria repens were recorded during 2010-2014 (species determination for three of them was confirmed besides morphological also by DNA analysis). At least, three of the cases were of autochthonous origin (the patients are Czech citizens residing in South Moravian Region who have never travelled abroad). The findings confirm the natural setting of D. repens in South Moravian Region of the CR. Dirofilariasis should be therefore considered as endemic in this area where it may represent a significant risk factor for public health. |
| doi_str_mv | 10.1186/s12879-016-1505-3 |
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The samples from five patients with suspected tissue helminthiases were investigated. In particular cases, nematodes were isolated from various tissues including skin of lower leg, soft tissues of finger, subcutaneous tissue of hypogastrium, lymph node and peritoneum. The diagnosis was based on light microscopic morphology and/or DNA analysis of the worms. In addition, ELISA examination of patients' sera for anti-filaria IgG antibodies was performed.
In the CR, five cases of human dirofilariasis caused by Dirofilaria repens were recorded during 2010-2014 (species determination for three of them was confirmed besides morphological also by DNA analysis). At least, three of the cases were of autochthonous origin (the patients are Czech citizens residing in South Moravian Region who have never travelled abroad). The findings confirm the natural setting of D. repens in South Moravian Region of the CR. Dirofilariasis should be therefore considered as endemic in this area where it may represent a significant risk factor for public health.</description><identifier>ISSN: 1471-2334</identifier><identifier>EISSN: 1471-2334</identifier><identifier>DOI: 10.1186/s12879-016-1505-3</identifier><identifier>PMID: 27094256</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adolescent ; Adult ; Animals ; Antibodies, Helminth - blood ; Case Report ; Czech Republic ; Dirofilaria repens - genetics ; Dirofilaria repens - isolation & purification ; Dirofilaria repens - metabolism ; Dirofilariasis - diagnosis ; Dirofilariasis - parasitology ; Dirofilariasis - pathology ; DNA, Helminth - genetics ; DNA, Helminth - metabolism ; Enzyme-Linked Immunosorbent Assay ; Health aspects ; Humans ; Immunoglobulin G ; Immunoglobulin G - blood ; Infectious diseases ; Influence ; Middle Aged ; Nematoda ; Physiological aspects ; Polymerase Chain Reaction ; Resveratrol ; RNA, Ribosomal, 5S - genetics ; RNA, Ribosomal, 5S - metabolism ; Skin - parasitology ; Skin - pathology ; Subcutaneous Tissue - parasitology ; Subcutaneous Tissue - pathology ; Young Adult</subject><ispartof>BMC infectious diseases, 2016-04, Vol.16 (165), p.171-171, Article 171</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>Matějů et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-d950cdf492ab5a7469b871b51abf62a01df0894ccbe1a8a5da47a881f2c81e263</citedby><cites>FETCH-LOGICAL-c562t-d950cdf492ab5a7469b871b51abf62a01df0894ccbe1a8a5da47a881f2c81e263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837637/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837637/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27094256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MatAjA¯, Jana</creatorcontrib><creatorcontrib>Chanova, Marta</creatorcontrib><creatorcontrib>Mitkova, Barbora</creatorcontrib><creatorcontrib>Hrazdilova, KristA1</creatorcontrib><creatorcontrib>KolaAova, LibuA e</creatorcontrib><title>Dirofilaria repens: emergence of autochthonous human infections in the Czech Republic (case reports)</title><title>BMC infectious diseases</title><addtitle>BMC Infect Dis</addtitle><description>Human dirofilariasis is a zoonotic infection that continues to spread to previously unaffected areas of Europe. In the South Moravian Region of the Czech Republic (CR), imported as well as autochthonous canine infections were recorded in the last decade, and parasite DNA was detected in mosquitoes of Aedes vexans. In the present paper, human Dirofilaria infections are reported from the country for the first time.
The samples from five patients with suspected tissue helminthiases were investigated. In particular cases, nematodes were isolated from various tissues including skin of lower leg, soft tissues of finger, subcutaneous tissue of hypogastrium, lymph node and peritoneum. The diagnosis was based on light microscopic morphology and/or DNA analysis of the worms. In addition, ELISA examination of patients' sera for anti-filaria IgG antibodies was performed.
In the CR, five cases of human dirofilariasis caused by Dirofilaria repens were recorded during 2010-2014 (species determination for three of them was confirmed besides morphological also by DNA analysis). At least, three of the cases were of autochthonous origin (the patients are Czech citizens residing in South Moravian Region who have never travelled abroad). The findings confirm the natural setting of D. repens in South Moravian Region of the CR. Dirofilariasis should be therefore considered as endemic in this area where it may represent a significant risk factor for public health.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Antibodies, Helminth - blood</subject><subject>Case Report</subject><subject>Czech Republic</subject><subject>Dirofilaria repens - genetics</subject><subject>Dirofilaria repens - isolation & purification</subject><subject>Dirofilaria repens - metabolism</subject><subject>Dirofilariasis - diagnosis</subject><subject>Dirofilariasis - parasitology</subject><subject>Dirofilariasis - pathology</subject><subject>DNA, Helminth - genetics</subject><subject>DNA, Helminth - metabolism</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>Infectious diseases</subject><subject>Influence</subject><subject>Middle Aged</subject><subject>Nematoda</subject><subject>Physiological aspects</subject><subject>Polymerase Chain Reaction</subject><subject>Resveratrol</subject><subject>RNA, Ribosomal, 5S - genetics</subject><subject>RNA, Ribosomal, 5S - metabolism</subject><subject>Skin - parasitology</subject><subject>Skin - pathology</subject><subject>Subcutaneous Tissue - parasitology</subject><subject>Subcutaneous Tissue - pathology</subject><subject>Young Adult</subject><issn>1471-2334</issn><issn>1471-2334</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkktv1DAUhSMEoqXwA9ggS2zaRYof8SMskKrhValSpfLYWo5zM3GV2FPbQcCvx6MppYNYIC98JX_32Pf4VNVzgk8JUeJVIlTJtsZE1IRjXrMH1SFpJKkpY83De_VB9SSla4yJVLR9XB1QiduGcnFY9W9dDIObTHQGRdiAT68RzBDX4C2gMCCz5GDHPAYfloTGZTYeOT-AzS74VEqUR0Crn2BHdAWbpZucRcfWJNjqhZjTydPq0WCmBM9u96Pqy_t3n1cf64vLD-ers4vackFz3bcc235oWmo6bmQj2k5J0nFiukFQg0k_YNU21nZAjDK8N400SpGBWkWACnZUvdnpllfM0FvwOZpJb6KbTfyhg3F6_8S7Ua_DN90oJgWTReD4ViCGmwVS1rNLFqbJeCjT6-IfY0xShgv68i_0OizRl_EK1UreCiXUH2ptJtDFtlDutVtRfdZwwphQeEud_oMqq4fZ2eChfBDsN5zsNRQmw_e8NktK-vzT1f-zl1_3WbJjbQwpRRjuvCNYbyOnd5HTJXJ6GznNSs-L-6bfdfzOGPsFhfnP8A</recordid><startdate>20160419</startdate><enddate>20160419</enddate><creator>MatAjA¯, Jana</creator><creator>Chanova, Marta</creator><creator>Mitkova, Barbora</creator><creator>Hrazdilova, KristA1</creator><creator>KolaAova, LibuA e</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7T2</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160419</creationdate><title>Dirofilaria repens: emergence of autochthonous human infections in the Czech Republic (case reports)</title><author>MatAjA¯, Jana ; 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In the South Moravian Region of the Czech Republic (CR), imported as well as autochthonous canine infections were recorded in the last decade, and parasite DNA was detected in mosquitoes of Aedes vexans. In the present paper, human Dirofilaria infections are reported from the country for the first time.
The samples from five patients with suspected tissue helminthiases were investigated. In particular cases, nematodes were isolated from various tissues including skin of lower leg, soft tissues of finger, subcutaneous tissue of hypogastrium, lymph node and peritoneum. The diagnosis was based on light microscopic morphology and/or DNA analysis of the worms. In addition, ELISA examination of patients' sera for anti-filaria IgG antibodies was performed.
In the CR, five cases of human dirofilariasis caused by Dirofilaria repens were recorded during 2010-2014 (species determination for three of them was confirmed besides morphological also by DNA analysis). At least, three of the cases were of autochthonous origin (the patients are Czech citizens residing in South Moravian Region who have never travelled abroad). The findings confirm the natural setting of D. repens in South Moravian Region of the CR. Dirofilariasis should be therefore considered as endemic in this area where it may represent a significant risk factor for public health.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27094256</pmid><doi>10.1186/s12879-016-1505-3</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Animals Antibodies, Helminth - blood Case Report Czech Republic Dirofilaria repens - genetics Dirofilaria repens - isolation & purification Dirofilaria repens - metabolism Dirofilariasis - diagnosis Dirofilariasis - parasitology Dirofilariasis - pathology DNA, Helminth - genetics DNA, Helminth - metabolism Enzyme-Linked Immunosorbent Assay Health aspects Humans Immunoglobulin G Immunoglobulin G - blood Infectious diseases Influence Middle Aged Nematoda Physiological aspects Polymerase Chain Reaction Resveratrol RNA, Ribosomal, 5S - genetics RNA, Ribosomal, 5S - metabolism Skin - parasitology Skin - pathology Subcutaneous Tissue - parasitology Subcutaneous Tissue - pathology Young Adult |
| title | Dirofilaria repens: emergence of autochthonous human infections in the Czech Republic (case reports) |
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